Ethical implementation of mitochondrial donation in Australia

Koplin, Julian; Lestrell, Esther; Mills, Catherine; Degeling, Chris; Kneebone, Ezra; Ludlow, Karinne; Newson, Ainsley J; Sparrow, Robert; Sutton, Liz; Warren, Narelle

doi:10.1111/ajo.13603

Cited by 3 publications

(3 citation statements)

References 14 publications

(30 reference statements)

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“…Interestingly, the themes we have identified in the submissions to the Australian Senate Community Affairs Legislation Committee overlaps largely—though not entirely—with the major themes in the ethics literature on mitochondrial donation (Newson, Wilkinson and Wrigley 2016 ). Major overlapping themes in the ethics literature include questions about how much importance we should place on opening new reproductive options for women at risk of transmitting mitochondrial diseases (Koplin et al 2022 ), what kind(s) of consent should be required from mitochondrial donors (Schaefer 2018 ), and whether male embryos should be selected in order to minimize risks to future generations (Brandt 2018 ).…”

Section: Discussionmentioning

confidence: 99%

The Parliamentary Inquiry into Mitochondrial Donation Law Reform (Maeve’s Law) Bill 2021 in Australia: A Qualitative Analysis

Allen,

Gyngell,

Koplin

et al. 2023

Bioethical Inquiry

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Recently, Australia became the second jurisdiction worldwide to legalize the use of mitochondrial donation technology. The Mitochondrial Donation Law Reform (Maeve’s Law) Bill 2021 allows individuals with a family history of mitochondrial disease to access assisted reproductive techniques that prevent the inheritance of mitochondrial disease. Using inductive content analysis, we assessed submissions sent to the Senate Committee as part of a programme of scientific inquiry and public consultation that informed drafting of the Bill. These submissions discussed a range of bioethical and legal considerations of central importance to the political debate. Significantly, submissions from those with a first-hand experience of mitochondrial disease, including clinicians and those with a family history of mitochondrial disease, were in strong support of this legislation. Those in support of the Bill commended the two-staged approach and rigorous licencing requirements as part of the Bill’s implementation strategy. Submissions which outlined arguments against the legislation either opposed the use of these techniques in general or opposed aspects of the implementation strategy in Australia. These findings offer a window into the ethical arguments and perspectives that matter most to those Australians who took part in the Senate inquiry into mitochondrial donation. The insights garnered from these submissions may be used to help refine policy and guidelines as the field progresses.

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Section: Discussionmentioning

confidence: 99%

The Parliamentary Inquiry into Mitochondrial Donation Law Reform (Maeve’s Law) Bill 2021 in Australia: A Qualitative Analysis

Allen,

Gyngell,

Koplin

et al. 2023

Bioethical Inquiry

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show abstract

“…This issue contains a fascinating Opinion piece from Koplin et al, 'Ethical implementation of mitochondrial donation in Australia.' 17 In March this year, the Australian parliament passed a Bill to allow the Aust N Z J Obstet Gynaecol 2022; 62: 811-812…”

Section: The End Of An Era For 'The Red Journal'mentioning

confidence: 99%

“…Since becoming editor of ANZJOG in 2016 I have welcomed articles of opinion, evidence‐based and well argued, in the Journal. This issue contains a fascinating Opinion piece from Koplin et al, ‘Ethical implementation of mitochondrial donation in Australia.’ 17 In March this year, the Australian parliament passed a Bill to allow the use of mitochondrial donation to prevent transmission of severe mitochondrial disease; mitochondrial donation uses sperm and ovum in an in vitro fertilisation procedure but the mitochondria are removed from the ovum and healthy donated mitochondria from a third person introduced, so the embryo, and ultimately the child, has in a sense three parents. Clinical trials of the procedure are ongoing in Australia.…”

mentioning

confidence: 99%