Ether-lipids and cellular signaling: A differential role of alkyl- and alkenyl-ether-lipids?

Papin, Marion; Bouchet, Ana Maria; Chantôme, Aurélie; Vandier, Christophe

doi:10.1016/j.biochi.2023.09.004

Cited by 4 publications

(1 citation statement)

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“…Thus, our results suggest that ether PI can be a good marker of peroxisome-derived lipid synthesis. Ether lipids are thought to have important cellular functions, while being altered in various diseases including cancer 10,20 . Ether lipid deficiency leads to the severe genetic disease rhizomelic chondrodysplasia punctata 21 .…”

Section: Discussionmentioning

confidence: 99%

Acyltransferases in the first step of glycerophospholipid synthesis have redundant and non-redundant roles insn-1 acyl chain regulation, ether lipid levels, and cell survival

Salame,

Qasmaoui,

Jose

et al. 2024

Preprint

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The increased use of lipidomics analyses in biomedical research made it crucial to understand correctly how lipid compositions are regulated. Lipid acyl chains are important regulators of membrane physicochemical properties, and are incorporated by various acyltransferases. The acyltransferases implicated in the first step of glycerophospholipid synthesis, the GPATs and GNPAT, have distinct localizations and substrate preferences. This suggests that they have distinct roles on lipid regulation, but a complete understanding of their redundant and non-redundant functions is missing. We report here a comprehensive analysis of cells having mutations in GPATs and GNPAT, either alone or in combinations. Our results suggest that the balance between GPATs and GNPAT affect the levels of ether lipids, together with glycerophospholipid acyl chain length and unsaturation. In addition, we found that lipid synthesis initiated at peroxisomes, but not mitochondria, is sufficient to provide the lipid synthesis flux required for normal cell growth. Our study unveils the multifaceted roles of the first step of de novo glycerophospholipid synthesis, thus leading to a better understanding of how lipidomes are shaped.

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Section: Discussionmentioning

confidence: 99%