Ethanolic Seed Extract of Grapefruit (Citrus paradisi Macfad) as an Effective Attenuator of Doxorubicin-Induced Oxidative Stress in the Rat Heart

Saalu, L.C.; Ajayi, G. O.; Adeneye, AA; Imosemi, I. O.; Osinubi, AA

doi:10.3923/ijcr.2009.44.52

Cited by 19 publications

(5 citation statements)

References 30 publications

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“…At a lower dose (200 mgkg -1 daily orally) CPF, the liver histolgical profiles and oxidative status parameters were preserved and even enhanced. This conforms to several reported beneficial effects of another component of C. paradisi demonstrated in our previous studies (Saalu et al, 2009;Saalu, 2010). This could be due to the unique phytochemical composition of the juice of C. paradisi.…”

Section: Discussionsupporting

confidence: 93%

The hepato-rejuvinative and hepato-toxic capabilities of Citrus paradisi Macfad fruit juice in Rattus Norvegicus

Saalu¹,

Oyewopo²,

Enye³

et al. 2012

Afr. J. Pharm. Pharmacol.

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Citrus paradisi Macfad (Rutaceae) popularly called grapefruit is widely cultivated in tropical and subtropical countries. The juice of C. paradisi fruit is commonly used both as a beverage and in folkforic medicine for the treatment of several disease conditions. In the present study, the effects of C. paradisi fruit juice on the Wistar rat liver histology and oxidative status were investigated. 200, 400 and 600 mgkg-1 per day orally of the extract was administered on three groups of Wistar rats respectively for 60 days. A fourth group that served as control was given 5 mlkg-1 daily, orally of distilled water. Animals that had 200 mgkg-1 of the extract showed improved liver histology and a largely preserved liver oxidative status. However, the groups of rats that were treated with both 400 and 600 mgkg-1 of the extract exhibited poor histological profiles and increased evidence of liver oxidative stress. The results therefore indicate that, while the lower dose of C. paradisi fruit juice is hepato-protective, the higher doses indeed demonstrate hepato-toxicity in the rat. Thus, the dose of application of the extract in folk medicine and even in beverages should be regulated to forestall possible hepatic derangement.

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Section: Discussionsupporting

confidence: 93%

The hepato-rejuvinative and hepato-toxic capabilities of Citrus paradisi Macfad fruit juice in Rattus Norvegicus

Saalu¹,

Oyewopo²,

Enye³

et al. 2012

Afr. J. Pharm. Pharmacol.

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show abstract

“…Findings from epidemiological studies suggest an association between grapefruit ( Citrus paradisi L .) consumption and reduced risk of coronary heart disease mortality [ 47 ]. In addition to the wide range of essential vitamins and minerals, grapefruit is rich in carotenoids and flavonoids.…”

Section: Cardioprotective Potential Of Foods and Phytochemicals During Dox Chemotherapymentioning

confidence: 99%

Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review

Koss-Mikołajczyk

Todorović

Šobajić

et al. 2021

IJMS

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Cardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effectiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is the stimulation of oxidative stress by chemotherapy. This suggests that an appropriately designed diet or dietary supplements based on edible plants rich in antioxidants could decrease the toxicity of antitumor drugs and diminish the risk of cardiac failure. This comprehensive review compares the cardioprotective efficacy of edible plant extracts and foodborne phytochemicals whose beneficial activity was demonstrated in various models in vivo and in vitro. The studies selected for this review concentrated on a therapy frequently applied in cancer, anthracycline antibiotic—doxorubicin—as the oxidative stress- and cardiotoxicity-inducing agent.

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“…Different pharmacological experiments on in vitro and in vivo models have reported the ability of grapefruit to exhibit antifungal, antibacterial and antioxidant properties; these are in addition to the several therapeutic uses of the fruit juice [ 12 , 13 ]. Moreover, phenolic compounds isolated from grapefruit have exhibited good antioxidant activity, while the volatile aroma compounds make them excellent flavouring agents [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Profiling, Toxicity and Anti-Inflammatory Activities of Essential Oils from Three Grapefruit Cultivars from KwaZulu-Natal in South Africa

et al. 2021

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The medicinal potential and volatile composition of different parts of three cultivars of grapefruit (Citrus paradisi) were evaluated for their toxicity and anti-inflammatory activities. Fresh leaf and fruit peel were separately isolated by hydrodistillation for 4 h. The essential oils were subjected to GC/GC-MS analysis for chemical profile. Toxicity of the essential oils in mice were evaluated using Lorke’s method, while an anti-inflammatory assay was performed in a rat model using egg albumin-induced oedema. The oils obtained were light yellow in colour, and odour varied from strong citrus smell to mild. Percentage yield of fresh peel oil (0.34–0.57%) was greater than the fresh leaf oil yield (0.21–0.34%). D-limonene (86.70–89.90%) was the major compound identified in the leaf oil, while β-phellandrene (90.00–91.01%) dominated the peel oil. At a dosage level of 5000 mg/kg, none of the oils showed mortality in mice. An anti-inflammatory bioassay revealed that all the oils caused a significant (p < 0.05–0.01) reduction in oedema size when compared to the negative control group throughout the 5 h post induction assessment period. The study reveals that the oils are non-toxic and demonstrate significant anti-inflammatory activity. Our findings suggest that the leaf and peel oils obtained from waste parts of grapefruit plants can be useful as flavouring agents, as well as anti-inflammatory agents.

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Ethanolic Seed Extract of Grapefruit (Citrus paradisi Macfad) as an Effective Attenuator of Doxorubicin-Induced Oxidative Stress in the Rat Heart

Cited by 19 publications

References 30 publications

The hepato-rejuvinative and hepato-toxic capabilities of Citrus paradisi Macfad fruit juice in Rattus Norvegicus

The hepato-rejuvinative and hepato-toxic capabilities of Citrus paradisi Macfad fruit juice in Rattus Norvegicus

Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review

Chemical Profiling, Toxicity and Anti-Inflammatory Activities of Essential Oils from Three Grapefruit Cultivars from KwaZulu-Natal in South Africa

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