Ethanolic Extract from Derris scandens Benth Mediates Radiosensitzation via Two Distinct Modes of Cell Death in Human Colon Cancer HT-29 Cells

Hematulin, Arunee; Ingkaninan, Kornkanok; Limpeanchob, Nanteetip; Sagan, Daniel

doi:10.7314/apjcp.2014.15.4.1871

Cited by 19 publications

(11 citation statements)

References 35 publications

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“…In addition, treatment of cells with D. scandens extract prior irradiation restores the ability of Hep-2 cells to halt the cell cycle at G2/M phase. This result is contradictory to our previous report for radiosensitizing potential of D. Scandens extract on colon cancer HT-29 cells, where extract treatment abolishes G2/M cell cycle arrest (Hematulin, 2011). The G2 checkpoint is a mandatory checkpoint that arrest cells at G2/M phase following radiation-induced DNA damage (Kastan & Bartek, 2004;Sancar et al, 2004;Deckbar et al, 2011).…”

Section: Discussioncontrasting

confidence: 96%

Derris scandens Benth Extract Potentiates Radioresistance of Hep-2 Laryngeal Cancer Cells

Hematulin

Meethang²,

Ingkaninan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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). Since radiation response of tumors is controlled by multiple factors, including individual genetic background, tumor type, stage, and type of mutations present (Verheij et al., 2010), more studies are needed to not only to identify novel radiozensitizers or radioporetectors, but also to provide essential information of the mechanisms of their actions. Although the use of radiomodulators for improving radiotherapy efficiency

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Section: Discussioncontrasting

confidence: 96%

Derris scandens Benth Extract Potentiates Radioresistance of Hep-2 Laryngeal Cancer Cells

Hematulin

Meethang²,

Ingkaninan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…A homeopathic medicine, Ruta isolated from Ruta graveolens was found to induce telomere erosion and mitotic catastrophe in human brain cancer and HL-60 leukemia cells in vitro and in vivo [335]. Ethanolic extract of Derris scandens Benth is a potent radiosensitizer of human colon cancer HT29 cells, as described in [336]. Treatment of HT29 cells with D. scandens extract in combination with gamma irradiation synergistically sensitizes HT29 cells to mitotic catastrophe by decreasing ERK1/2 activation [336].…”

Section: Natural Compounds and Other Cell Death Pathwaysmentioning

confidence: 99%

“…Ethanolic extract of Derris scandens Benth is a potent radiosensitizer of human colon cancer HT29 cells, as described in [336]. Treatment of HT29 cells with D. scandens extract in combination with gamma irradiation synergistically sensitizes HT29 cells to mitotic catastrophe by decreasing ERK1/2 activation [336]. …”

Section: Natural Compounds and Other Cell Death Pathwaysmentioning

confidence: 99%

Natural Compounds As Modulators of Non-apoptotic Cell Death in Cancer Cells

Guamán-Ortiz

Orellana²,

Ratovitski³

2017

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Cell death is an innate capability of cells to be removed from microenvironment, if and when they are damaged by multiple stresses. Cell death is often regulated by multiple molecular pathways and mechanism, including apoptosis, autophagy, and necroptosis. The molecular network underlying these processes is often intertwined and one pathway can dynamically shift to another one acquiring certain protein components, in particular upon treatment with various drugs. The strategy to treat human cancer ultimately relies on the ability of anticancer therapeutics to induce tumor-specific cell death, while leaving normal adjacent cells undamaged. However, tumor cells often develop the resistance to the drug-induced cell death, thus representing a great challenge for the anticancer approaches. Numerous compounds originated from the natural sources and biopharmaceutical industries are applied today in clinics showing advantageous results. However, some exhibit serious toxic side effects. Thus, novel effective therapeutic approaches in treating cancers are continued to be developed. Natural compounds with anticancer activity have gained a great interest among researchers and clinicians alike since they have shown more favorable safety and efficacy then the synthetic marketed drugs. Numerous studies in vitro and in vivo have found that several natural compounds display promising anticancer potentials. This review underlines certain information regarding the role of natural compounds from plants, microorganisms and sea life forms, which are able to induce non-apoptotic cell death in tumor cells, namely autophagy and necroptosis.

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“…Curcumin is undoubtly inducing crosstalk between apoptosis and autophagy mutual proteins to regulate cancer cell death. For most of the researchers, the course of cancer advancement has always been attributed for a great part to the defectiveness in cell death mechanisms [203,204]. These defects act as a shield in protecting tumor cells from drugs and therapies, all at the same time, maintaining a longer life span and prompting their dispersion procedures.…”

Section: Resultsmentioning

confidence: 99%

Curcumin a Multifaceted Compound with Hormetic Behaviour that Mediates an Intricate Crosstalk between Mitochondrial Biogenesis, Mitophagy, Mitophagic Death and Apoptosis

Rainey¹,

Moustapha²,

Parker³

et al. 2017

Preprint

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Curcumin, found in the rhizome of turmeric, has extensive therapeutic promises via its antioxidant, anti-inflammatory, and antiproliferative properties. Preclinical in vitro and in vivo data have shown curcumin to be an effective treatment for multiple cancers. These effects are drived by curcumin's ability to induce G2/M cell cycle arrest, induction of autophagy, activation of apoptotic pathways, disruption of molecular signaling, inhibition of invasion and metastasis, and by increasing the efficacy of existing chemotherapeutics. Here we focused on the hormetic behaviour of curcumin. Frequently, low doses of toxins and other stressors not only are harmless but also activate an adaptive stress whereas high dose activates acute responses like autophagy and cell death. This phenomenon is referred to as hormesis. Many molecules that cause cell death elicite an initial autophagic step that is a cytoprotective mechanism relying on elimination of dysfunctional structures intracellular, notably by mitophagy. This phenomenon is considered as a primarily protective mechanism against stressors. At higher doses, cells undergo mitochondrial outer membrane permeabilization due to calcium release from the endoplasmic reticulum and die. Herein, we address the complex crosstalk between the induced mitochondrial biogenesis, mitochondrial destabilization accompanied by mitophagy and cell death that can also be at play.

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Ethanolic Extract from Derris scandens Benth Mediates Radiosensitzation via Two Distinct Modes of Cell Death in Human Colon Cancer HT-29 Cells

Cited by 19 publications

References 35 publications

Derris scandens Benth Extract Potentiates Radioresistance of Hep-2 Laryngeal Cancer Cells

Derris scandens Benth Extract Potentiates Radioresistance of Hep-2 Laryngeal Cancer Cells

Natural Compounds As Modulators of Non-apoptotic Cell Death in Cancer Cells

Curcumin a Multifaceted Compound with Hormetic Behaviour that Mediates an Intricate Crosstalk between Mitochondrial Biogenesis, Mitophagy, Mitophagic Death and Apoptosis

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