Ethanolic extract and water-soluble polysaccharide from Chaenomeles speciosa fruit modulate lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophage cells

Zhu, Qing; Chao-lin, Liao; Liu, Yongmei; Wang, Pengcheng; Guo, Wei; He, Meijun; Huang, Zebo

doi:10.1016/j.jep.2012.09.042

Cited by 21 publications

(9 citation statements)

References 21 publications

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“…The n-BuOH fraction of m 2 SMS showed the highest activity in the LPO and DPPH assays, whereas the n-BuOH fraction of m 1 SMS had the most significant effect in the tyrosinase assay. Previous studies have shown Fructus Chaenomelis to have good immune-modulatory, anti-inflammatory, and antioxidant effects [3,[12][13][14]. These effects were confirmed as all extracts of Fructus Chaenomelis showed strong activities in the three assays.…”

Section: Lipid Peroxidation Inhibition Assaysupporting

confidence: 61%

In Vitro Anti-inflammatory and Antioxidant Potential of Si-Miao-San, its Modifications and Pure Compounds

Lower-Nedza

Kuess

Zhao

et al. 2013

Natural Product Communications

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The ancient Chinese prescription Si-Miao-San (SMS), which is widely used for the treatment of various diseases, e.g. rheumatic disorders, has been modified (m1SMS, m2SMS). The purpose of this study was to investigate the anti-inflammatory, antioxidant, and anti-tyrosinase effects of Si-Miao-San, of its two modifications, the component herbs, and its main pure ingredients. In vitro tyrosinase, 2,2-diphenyl-1-picrylhydrazyl (DPPH), and lipid peroxidation (LPO) assays were carried out in order to determine the inhibitory potential of the samples. The traditionally applied decoctions as well as their fractions ( n-hexane, DCM, n-BuOH) were tested for their activities in concentrations of 100 μg/mL and 400 μg/mL, and the pure compounds in a range 6.25 μg/mL to 100 μg/mL. In conclusion, the decoction of m2SMS exhibited strong antioxidant activity in the DPPH assay, while the decoction of the classical SMS formulation showed low activity. The present results have shown the modifications to be more efficient scavengers of free radicals, such as superoxide and peroxide radicals. In addition, the decoctions of the two modifications have been shown to be more potent tyrosinase inhibitors. These formulas may thus be used as anti-inflammatory and anti-aging prescriptions, as they may help to prevent cell damage. This study clearly establishes the two modifications of Si-Miao-San as valuable sources of natural antioxidants and anti-inflammatory agents, and also as candidates in the search for modern pharmaceuticals.

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Section: Lipid Peroxidation Inhibition Assaysupporting

confidence: 61%

In Vitro Anti-inflammatory and Antioxidant Potential of Si-Miao-San, its Modifications and Pure Compounds

Lower-Nedza

Kuess

Zhao

et al. 2013

Natural Product Communications

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“…In contrast, the combination of Chaenomeles speciosa (Mugua) reduces wind and moisture while treating the tip simultaneously. Studies have shown that, 24–28 Chaenomeles Speciosa (Mugua), Codonopsis Radix (Danshen), and turmeric (Jianghuang) all serve major anti-inflammatory roles. Chaenomeles speciosa (Mugua) has been widely employed in the clinical treatment of inflammatory illnesses.…”

Section: Discussionmentioning

confidence: 99%

To Explore the Herbal Combinations and Pharmacological Mechanisms of Yourong Huang in the Treatment of Cervical Spondylosis Based on Data Mining and Network Pharmacology

Chai

Huang

Han

et al. 2023

Natural Product Communications

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Objective: Yourong Huang's drug administration pattern in treating cervical spondylosis (CS) was discussed and evaluated, and the likely mechanism of the high-frequency drug in the treatment of CS to give a reference for the clinical treatment of CS. Materials & methods: The cases of Yourong Huang treating CS were collected, to provide association rules between high-frequency drug pairs, IBM SPSS Statistics 22.0 and IBM SPSS Modeler18.0 were employed. Build a network relationship between “CS core target-active ingredient-drug” was constructed. Results: Two hundred and sixty-two prescriptions were collected, 117 drugs were used, and 2882 doses were taken. Through systematic analysis, the core drug Shaoyao-Mugua Decoction (SYMGD) was discovered. A total of 206 active ingredients were found in the 8 high-frequency prescription drugs. There were 71 potential targets for SYMGD treatment of CS. A total of 158 items were identified by KEGG enrichment analysis, the most important of which were 5 signaling pathways. According to the molecular docking results, SYMGD had good binding activity to its therapeutic targets. Discussion & conclusion: Yourong Huang treated CS with Chinese medicine by “reinforcing liver and kidney, warmly invigorating spleen and stomach, activating blood and resolving stasis.” SYMGD, a core drug group, treats CS through a multicomponent, multitarget, and multipathway comprehensive intervention. Comprehensive analysis calculate the minimum binding energy between 5 key active ingredients and 5 key targets, knowable that SYMGD had good binding activity to its therapeutic target, proving that the prediction of this study was reliable.

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“…Macrophages play critical roles in innate and adaptive immune responses to pathogens through phagocytosis, antigen presentation, and cytokines secretion [ 43 ]. In these cells, the iNOS gene regulates the production of NO which is a well-known pro-inflammatory mediator [ 44 ] and secrete pro-inflammatory cytokines such as TNF-α and IL-1β [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Co-immunomodulatory Activities of Anionic Macromolecules Extracted from Codium fragile with Red Ginseng Extract on Peritoneal Macrophage of Immune-Suppressed Mice

Kim¹,

Monmai²,

Rod-in³

et al. 2020

Journal of Microbiology and Biotechnology

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Ethanolic extract and water-soluble polysaccharide from Chaenomeles speciosa fruit modulate lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophage cells

Cited by 21 publications

References 21 publications

In Vitro Anti-inflammatory and Antioxidant Potential of Si-Miao-San, its Modifications and Pure Compounds

In Vitro Anti-inflammatory and Antioxidant Potential of Si-Miao-San, its Modifications and Pure Compounds

To Explore the Herbal Combinations and Pharmacological Mechanisms of Yourong Huang in the Treatment of Cervical Spondylosis Based on Data Mining and Network Pharmacology

Co-immunomodulatory Activities of Anionic Macromolecules Extracted from Codium fragile with Red Ginseng Extract on Peritoneal Macrophage of Immune-Suppressed Mice

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