Ethanol tolerance from a Pavlovian perspective.

González, Valeria V.; Míguez, Gonzalo; Quezada, Vanetza E.; Mallea, Jorge; Laborda, Mario A.

doi:10.1037/pne0000181

Cited by 5 publications

(3 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If incentive salience was a contributing factor in the maintenance of front-loading, the hypothesis is that front-loading would decrease in a context where alcohol has not previously been offered. However, we also note that an additional or alternative explanation for this finding could be that context-dependent front-loading is driven by context-dependent tolerance, a phenomenon documented in alcohol use (González et al, 2019;.…”

Section: Front-loading : a Role For In Centive Salien Ce?mentioning

confidence: 56%

A critical review of front‐loading: A maladaptive drinking pattern driven by alcohol's rewarding effects

Ardinger

Lapish

Czachowski

et al. 2022

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

Temporal analysis of alcohol intake patterns may lead to a more complete understanding of the development of alcohol use disorder (AUD). There is evidence that a quick rate of alcohol intake, not just a high total amount of alcohol consumed, is correlated with AUD symptoms. Recent examples supporting this include a relationship between binge-drinking rate and AUD symptoms in adolescents (Carpenter et al., 2019), as well as heavy drinkers and individuals considered at risk for AUD self-administering intravenous alcohol at a quicker rate than low-risk "social drinkers" (Sloan et al., 2019).Front-loading is a drinking pattern where intake is skewed toward the onset of reward access. Front-loading has been reported across several different alcohol self-administration protocols using a variety of species (Table 1). Although there is literature describing front-loading as a measure of reward-related behavior during the consumption of sweetened solutions, such as sucrose and saccharin

show abstract

Section: Front-loading : a Role For In Centive Salien Ce?mentioning

confidence: 56%

A critical review of front‐loading: A maladaptive drinking pattern driven by alcohol's rewarding effects

Ardinger

Lapish

Czachowski

et al. 2022

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

show abstract

“…For example, one might expect a larger effect of a glass of wine when consumed at lunchtime (assuming that is atypical for the drinker) than in a customary drinking context such as an evening party. Such occurrences have been well-documented in the opioid use literature whereby individuals incur fatal overdoses after self-administering a customary dose that would not be expected to be deadly for individuals who are experienced with and tolerant to the substance; such effects have also been demonstrated in nonhuman animals (see González et al, 2019;Siegel, 2016, for detailed discussions).…”

mentioning

confidence: 96%

Self-report assessment of alcohol sensitivity: An examination of the effects of different probes.

Boness¹,

Sher²

2023

Psychology of Addictive Behaviors

View full text Add to dashboard Cite

Objective: Level of response (LOR) to alcohol is associated with several alcohol-related risk factors and outcomes. However, existing self-report measures of LOR have important limitations. For example, the Self-Rating of the Effects of Alcohol Scale assesses a limited range of alcohol-related effects. Although the Alcohol Sensitivity Questionnaire (ASQ) samples a broader range of effects, it uses different probes across effects, confounding type of effect with method variation associated with the use of different probes. Focusing on the ASQ, we systematically evaluate variation in estimated LOR as a function of how number of drinks to achieve an effect is probed. Our approach addresses a major limitation of existing LOR measures which fail to account for sensitivity variability across drinking occasions. Method: This study randomized 732 adult drinkers into one of four versions of the ASQ that assessed sensitivity to 15 alcoholrelated effects, systematically varying the follow-up probes. Results: Accounting for (a) the minimum number of drinks consumed before feeling an effect and (b) the maximum number of drinks consumed without feeling an effect for all effects is superior to the original ASQ approach in predicting relevant outcomes. Conclusions: Assessments of sensitivity should probe for minimum and maximum number of drinks across each of the effects. If impractical to probe for both, consistently probing for maximum number of drinks is desirable. Public Health Significance StatementLevel of response (LOR) to alcohol is associated with a range of alcohol-related risk factors and outcomes. The present study demonstrates the value of refining the assessment of LOR by considering variability in sensitivity across drinking occasions. Improved assessment can lead to improved detection of those with low LOR who may be at the most risk for alcohol dependence and related problems.

show abstract

“…Although Solomon and Corbit's (1974) model has been successful in explaining several aspects of the development of tolerance to drug effects following chronic administration (e.g., Baker & Tiffany, 1985), it is unable to explain why chronic tolerance is sometimes observed and sometimes not (San Martín et al, 2017). This could be because this model does not consider the contextual specificity of drug tolerance (González et al, 2019). Contextual specificity refers to the observation that tolerance occurs in the presence of environmental and contextual cues that have been previously paired with drug administration (Gonzalez et al, 2019;San Martin et al, 2017).…”

mentioning

confidence: 99%

Exploring the Associative Determinants of Tolerance to the Effects of Cannabis on Locomotion

Varas¹,

Míguez²,

Quezada-Scholz³

et al. 2023

Preprint

View full text Add to dashboard Cite

Experimental evaluation of cannabis tolerance has to date lacked an associative approximation, focusing primarily on physiological variables. The present study assessed acute effects, chronic tolerance, and contextual specificity, exploring a potential associative component underlying cannabis tolerance. Sixteen adult Sprague-Dawley rats of both sexes were assigned to two groups, one receiving vaporized administrations of cannabis and the other receiving the vehicle substance, in two different (counterbalanced) contexts. An initial measurement was performed to assess acute effects, followed by four measurements to evaluate the development of chronic tolerance, and a final measurement to test the context specificity of tolerance, comparing the responses to the usual administration context and a novel context. Ten behaviors were analyzed in an open field. Acute effects were observed in seven indicators, corresponding to greater locomotor activity in the group that received the drug compared to the control group. In five of these, the data also showed the development of chronic tolerance to the effects of cannabis on locomotion, which was indicated by a progressive decrease in locomotor activity in the drug group. However, no evidence of context specificity was found in any of the variables in which chronic tolerance was observed. We discuss factors that may be related to the lack of contextual specificity of cannabis tolerance. Together, our findings show that a single administration of cannabis induces acute effects, and its consecutive consumption develops chronic tolerance to these effects, reaching a hypolocomotor state.

show abstract

Ethanol tolerance from a Pavlovian perspective.

Cited by 5 publications

References 64 publications

A critical review of front‐loading: A maladaptive drinking pattern driven by alcohol's rewarding effects

A critical review of front‐loading: A maladaptive drinking pattern driven by alcohol's rewarding effects

Self-report assessment of alcohol sensitivity: An examination of the effects of different probes.

Exploring the Associative Determinants of Tolerance to the Effects of Cannabis on Locomotion

Contact Info

Product

Resources

About