“…Further open questions are the interesting connection of alcohol actions with the adenosine receptors (Dar et al, 1983;Choi et al, 2004;Dar, 2006), protein kinases (Hodge et al, 1999;Proctor et al, 2003;Wallace et al, 2007), NMDA and AMPA receptors (Lovinger et al, 1989;Woodward, 2000), BK channels (Martin et al, 2004;Cowmeadow et al, 2006), glycine receptors (Davies et al, 2003), K v + channels (Espinosa et al, 2001), and the modulation of alcohol actions via G protein-coupled receptors (Wan et al, 1996;Nie et al, 2004;Besheer et al, 2006) as well as the molecular mechanism behind of the fascinating observation of behavioral alcohol antagonism by pressure (Alkana et al, 1985;Davies and Alkana, 2001). The challenge is to find answers to these and many more important questions in the future and to integrate these findings into an increasingly comprehensive picture on which the majority of us can agree.…”