Ethanol sclerotherapy of peripheral venous malformations

Rimon, Uri; Garniek, Alexander; Galili, Yair; Golan, Gil; Bensaid, Paul; Morag, B

doi:10.1016/j.ejrad.2003.09.010

Cited by 77 publications

(55 citation statements)

References 11 publications

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“…In order to have the maximal score, the patient needed to have improvement in all items ( Table 2). Even with this stringent and detailed grading, our results with gelified ethanol were as good as those of our initial study, as those by Berenguer and co-workers using absolute ethanol, and as others evaluating with more general criteria [10,12,[38][39][40][41].…”

Section: Discussionsupporting

confidence: 77%

“…Ideally, the sclerosant should cause vascular injury and remain in place for sufficient time to permanently injure the endothelium [8]. Among the sclerosing agents, absolute ethanol is the most effective one with the lowest recurrence rate [9][10][11][12]. It causes instant precipitation of endothelial cell proteins through denaturization and cellular dehydration.…”

Section: Introductionmentioning

confidence: 98%

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Radio-opaque ethylcellulose-ethanol is a safe and efficient sclerosing agent for venous malformations

et al. 2011

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Per mL used, radio-opaque gelified ethanol is at least as effective as absolute ethanol. No systemic complication was observed, as only a low dose of ethanol was injected. Indications for sclerotherapy can be widened to areas with higher risk for local side effects (hands and periocular region), as ethanol is trapped in the lesion. Careful injection procedure is though necessary, because only a limited amount of ethylcellulose can be used per puncture. Key Points • Development of a new sclerosing agent for venous malformations. • Interesting novel way to deliver alcohol to slow-flow vascular malformations. • Alcohol-based with less local and systemic side-effects.

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Section: Discussionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 98%

Radio-opaque ethylcellulose-ethanol is a safe and efficient sclerosing agent for venous malformations

et al. 2011

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“…7 Use of ethanol is limited due to its local (pain, cellulitis, compartment syndrome, perivascular or local tissue damage such as skin necrosis, nerve injury, and deep venous thrombosis) and systemic (central nervous system depression, hypoglycemia, hypertension, distal embolization, remote organ damage, pulmonary vasospasm, and blood cell damage) side effects. 7,10,20,21 In our series, 27% of patients who underwent PES had one or more complications. There was one mortality after PES secondary to cardiovascular collapse.…”

Section: Discussionmentioning

confidence: 92%

Predictors of response to percutaneous ethanol sclerotherapy (PES) in patients with venous malformations: Analysis of patient self-assessment and imaging

Yun

Kim

Lee

et al. 2009

Journal of Vascular Surgery

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“…16 The use of ethanol for sclerotherapy may however be preferred in some centers owing to its lower cost and availability. 17 Still, the rate of disease recurrence seems to be the lowest among sclerosing agents. 18,19 However, sclerotherapy performed with STS has a much lower rate of complications, but could be less effective and more treatment session could be needed.…”

Section: Discussionmentioning

confidence: 99%

“…Silk fibroin (SF) is produced by Bombyx mori and considered as drug carrier. 17 SF and 4HR combination has been widely studied in tissue engineering for the development of soft tissue augmentation material 18 or membrane. 19 4HR can influence gene expression and protein function in cancer cells 20 and macrophages.…”

Section: Botulinum Toxin Conjugated With Silk Fibroin and 4-hexylresomentioning

confidence: 99%

Complications After Treatment of Head and Neck Venous Malformations With Sodium Tetradecyl Sulfate Foam

Colletti

Deganello

Bardazzi³

et al. 2017

Journal of Craniofacial Surgery

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ô#and Francesco Stillo, MD ÃÃ Purpose: The aim of this study was to evaluate complications in patients with head and neck venous malformations (VMs) treated with foam sclerotherapy using sodium tetradecyl sulfate (STS). Methods: The authors retrospectively evaluated the complications, pain. and degree of satisfaction in 69 consecutive patients affected by cervicofacial VM managed with STS using the Tessari method in a single institution. Results: The average number of procedures for each patient was 2.1. The most frequent complication was blistering. We observed 1 patient of temporary weakness of a facial nerve branch, 1 paradoxical embolism, and 1 orbital compartment syndrome.The average pain score was 0 (no pain at all) (51.5%). There was no statistically significant correlation between patient satisfaction and the presence of complications or the degree of pain. Conclusions: Sclerotherapy with STS is an effective treatment that yields to very high patient satisfaction. This procedure has an overall low complication rate and is usually effective within a few sessions. However, severe complications may occur; these must be pointed out in the informed consent and the surgeon must be aware of and ready to quickly treat them to prevent long-term sequelae.Key Words: complication, endovascular, sclerotherapy, sodium tetradecyl sulfate, vascular malformation, venous malformation V ascular malformations are developmental abnormalities of the vascular tree present from birth. They are classified based on the vessel type (capillary, venous, lymphatic, and arteriovenous) or on their rheologic characteristics (slow-flow or fast-flow).1 Venous malformations (VMs) are the most common vascular malformation, and their treatment remains very challenging.2 Forty percent to 60% of all VMs involve the head and neck area. Symptoms may vary and include cosmetic complaints, pain, swelling, and functional limitations. Frequently, localized intravascular coagulopathy 3-5 can take place in larger VMs and will worsen signs and symptoms. In more ''benign'' patients, symptoms can be so mild that no treatment is needed, with the exception of conservative measures; in other patient, symptoms are so severe that >1 treatment can be needed and the approach has to be increasingly invasive. [6][7][8] There are several options to treat VMs and these include sclerotherapy, surgery, or laser. 9 Overall, many descriptive studies are present in the literature regarding sclerotherapy. However, most focus on technical procedural aspects or short-term results only. The conclusion in many articles is that VMs are difficult to treat and that most patients require multiple therapeutic sessions before a clinically relevant effect is obtained.Many sclerosants such as ethanol, jellified ethanol, bleomycin, polidocanol, or sodium tetradecyl sulfate (STS) are available, and they show an effectiveness of 74%, 89%, 88%, 90%, and 86%, respectively, according to a recent analysis. 6 Ethanol is one of the most commonly used, and is a potent agent for all types of va...

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Ethanol sclerotherapy of peripheral venous malformations

Cited by 77 publications

References 11 publications

Radio-opaque ethylcellulose-ethanol is a safe and efficient sclerosing agent for venous malformations

Radio-opaque ethylcellulose-ethanol is a safe and efficient sclerosing agent for venous malformations

Predictors of response to percutaneous ethanol sclerotherapy (PES) in patients with venous malformations: Analysis of patient self-assessment and imaging

Complications After Treatment of Head and Neck Venous Malformations With Sodium Tetradecyl Sulfate Foam

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