Ethanol-induced behavioral sensitization is associated with dopamine receptor changes in the mouse olfactory tubercle

Araujo, N.P.; Fukushiro, D.F.; Grassl, Christian; Hipólide, Débora Cristina; Formigoni, Maria Lúcia Oliveira de Souza; Tufik, Sérgio; Frussa‐Filho, Roberto

doi:10.1016/j.physbeh.2008.07.029

Cited by 36 publications

(19 citation statements)

References 70 publications

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“…Rodent locomotor activity can be increased by administering rewarding stimuli and decreased by administering aversive stimuli (Bouwknecht et al 2007 ;Robinson & Berridge, 1993 . Evaluation of behaviour of mice in the open field was conducted for 10 min because even shorter periods have proved to be optimum for reliably and accurately evaluating the effects of drugs acting on dopaminergic systems (Castro et al 2006 ;Faria et al 2005 ;Frussa-Filho & Palermo-Neto, 1990Fukushiro et al 2007Fukushiro et al a, b, 2008Queiroz & Frussa-Filho, 1997) and particularly the stimulant effect and behavioural sensitization produced by Amp (Alvarez et al 2006 ;Araujo et al 2006 ;Bellot et al 1997 ;Calzavara et al 2008 ;Carvalho et al 2009 ;Chinen et al 2006 ;Costa et al 2001 ;Frussa-Filho et al 2004) and other drugs of abuse (Araujo et al 2005(Araujo et al , 2009Bellot et al 1996). Moreover, under our specific experimental conditions, we recently verified that the behavioural competition between Amp-induced hyperlocomotion and stereotypy in the open-field apparatus is much stronger when mouse behaviour is quantified after this optimum period (Frussa-Filho et al 2010).…”

Section: Open-field Testmentioning

confidence: 99%

Chronic amphetamine transforms the emotional significance of a novel but not a familiar environment: implications for addiction

Fukushiro

Frussa‐Filho

2010

Int. J. Neuropsychopharm.

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Both drug-induced locomotor sensitization and reactivity to novelty in rodents have been related to drug-craving mechanisms in humans. We investigated whether the exposure to a completely novel environment would modulate the expression of locomotor sensitization induced by repeated administration of amphetamine (Amp) in mice. In addition to locomotion, different open-field behavioural parameters were used to evaluate the possible involvement of anxiogenic-like effects induced by Amp, novelty or a combination of the two. In order to avoid misinterpretations due to different locomotor baseline conditions, we used an open-field illumination condition in which previous exposure to the apparatus did not modify locomotion (although it reliably increased grooming behaviour). Acute Amp administration increased locomotion in mice previously habituated to the open field (Hab) but not in mice exposed to the apparatus for the first time (Nov). This absence of Amp-induced locomotor activation in Nov mice may be related to higher anxiety-like levels, because these animals displayed longer freezing duration. However, only Nov mice developed locomotor sensitization. Because Amp challenge in Amp pre-treated Nov mice did not induce an increase in freezing behaviour, the locomotor sensitization in Nov mice might be related to the tolerance of Amp-induced anxiogenic-like behaviour in novel environments. Repeated Amp administration increased motivation to explore the environment in Nov mice in that these animals presented a within-session locomotion-habituation deficit. Our data suggest that a complex and plastic interaction between the anxiogenic and motivational properties of both novelty and Amp can critically modify the behavioural expression of craving-related mechanisms.

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Section: Open-field Testmentioning

confidence: 99%

Chronic amphetamine transforms the emotional significance of a novel but not a familiar environment: implications for addiction

Fukushiro

Frussa‐Filho

2010

Int. J. Neuropsychopharm.

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“…Repeated treatment and testing were performed between 08 : 00 and 11 : 00 hours. We chose a dose of Eth and a protocol of repeated treatment with Eth that produced, under our laboratory conditions, locomotor stimulation and sensitization of this effect in mice (Araujo et al 2005(Araujo et al , 2006b(Araujo et al , 2009Bellot et al 1996 ;Fukushiro et al unpublished data ;Kameda et al 2007). …”

Section: Drugmentioning

confidence: 99%

“…Repeated administration of Eth can lead to the development of behavioural sensitization in rodents (Araujo et al 2005(Araujo et al , 2006b(Araujo et al , 2009Bellot et al 1996 ;Camarini et al 2000a, b ;Masur & Boerngen, 1980 ;Phillips et al 1997). This phenomenon is characterized by a progressive enhancement of the motor-stimulant effects that occurs upon re-administration, even after long-term drug abstinence (Robinson & Becker, 1986).…”

Section: Introductionmentioning

confidence: 99%

“…Locomotor sensitization in rodents has been extensively used as a marker for the study of the molecular and cellular mechanisms underlying various features of addiction in humans, including drug craving, drugseeking behaviour and relapse (Robinson & Berridge, 1993). The development of Eth-induced locomotor sensitization is not completely understood, and a number of neurotransmitter systems have been implicated in this process, including dopamine (Araujo et al 2009 ;Nestby et al 1997), glutamate (Broadbent et al 2003 ;Camarini et al 2000b), GABA (Broadbent & Harless, 1999) and opioid peptides (Camarini et al 2000a ;Pastor & Aragon, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Acute and chronic ethanol differentially modify the emotional significance of a novel environment: implications for addiction

Fukushiro

Josino

Saito

et al. 2011

Int. J. Neuropsychopharm.

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Using open-field behaviour as an experimental paradigm, we demonstrated a complex interaction between the rewarding/stimulating effects and the anxiogenic/stressful effects of both novelty and acute or chronic amphetamine in mice. As a consequence of this interaction, acute amphetamine-induced hyperlocomotion was inhibited, whereas the expression of its sensitization was facilitated in a novel environment. In the present study, we aimed to investigate the interactions between exposure to a novel environment and the acute and chronic effects of ethanol (Eth), a drug of abuse known to produce anxiolytic-like behaviour in mice. Previously habituated and non-habituated male Swiss mice (3 months old) were tested in an open field after receiving an acute injection of Eth or following repeated treatment with Eth. Acute Eth administration increased locomotion with a greater magnitude in mice exposed to the apparatus for the first time, and this was thought to be related to the attenuation of the stressful effects of novelty produced by the anxiolytic-like effect of acute Eth, leading to a subsequent prevalence of its stimulant effects. However, locomotor sensitization produced by repeated Eth administration was expressed only in the previously explored environment. This result might be related to the well-known tolerance of Eth-induced anxiolytic-like behaviour following repeated treatment, which would restore the anxiogenic effect of novelty. Our data suggest that a complex and plastic interaction between the emotional and motivational properties of novelty and drugs of abuse can critically modify the behavioural expression of addiction-related mechanisms.

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“…Generally, low-to-moderate doses of ethanol may produce locomotor stimulant effects resulting from the enhancement of dopaminergic neurotransmission, which seems to be of great relevance to its positive reinforcing properties (de Araujo et al, 2009;BoerngenLacerda and Souza-Formigoni, 2000;Wise and Bozarth, 1987), whereas exposure to higher ethanol doses can result in the inhibition of locomotor activity and LORR. The depressant action of ethanol on the central nervous system has been thought to be involved in its negative reinforcing properties related to alleviating some negative events (e.g., anxiety or stress) and ⁄ or preventing ethanol withdrawal symptoms (Colombo et al, 1995;Eckardt et al, 1998).…”

Section: Effects Of Arecoline Plus Scopolamine or Methscopolamine On mentioning

confidence: 99%

Systemic Administration of Arecoline Reduces Ethanol‐Induced Sleeping Through Activation of Central Muscarinic Receptor in Mice

Sun

Liu²,

Luo³

et al. 2009

Alcoholism Clin & Exp Res

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Background: Epidemiological evidence of co-use of alcohol and areca nuts suggests a potential central interaction between arecoline, a major alkaloid of areca and a muscarinic receptor agonist, and ethanol. Moreover, the central cholinergic system plays an important role in the depressant action of ethanol and barbiturates. The purpose of this study was to investigate the effects of arecoline on pentobarbital-and ethanol-induced hypnosis in mice.Methods: Male ICR mice were tested for locomotor activity following acute systemic administration of ethanol alone, arecoline alone, or ethanol plus arecoline. For the loss of the righting reflex (LORR) induced by pentobarbital and ethanol, sleep latency and sleeping duration were evaluated in mice treated with arecoline alone or the combination of arecoline and scopolamine or methscopolamine.Results: Ethanol (1.0 to 3.0 g ⁄ kg, i.p.) reduced locomotor activity significantly and a declining trend was observed after treatment with arecoline (0.25 to 1.0 mg ⁄ kg, i.p.), but there were no synergistic effects of ethanol and arecoline on locomotor activity. The experiments on LORR demonstrated that arecoline (0.125 to 1.0 mg ⁄ kg, s.c.) shortened the duration of sleeping induced by ethanol (4.0 g ⁄ kg, i.p.), but not pentobarbital (45 mg ⁄ kg, i.p.). In addition, alterations of sleep latency were not obvious in both pentobarbital-and ethanol-induced LORR. Statistical analyses revealed that scopolamine (centrally acting), but not methscopolamine (peripherally acting), could antagonize the effect of arecoline on the duration of ethanol-induced LORR in mice.Conclusions: These results suggest that central muscarinic receptor is a pharmacological target for the action of arecoline to modulate ethanol-induced hypnosis.

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Ethanol-induced behavioral sensitization is associated with dopamine receptor changes in the mouse olfactory tubercle

Cited by 36 publications

References 70 publications

Chronic amphetamine transforms the emotional significance of a novel but not a familiar environment: implications for addiction

Chronic amphetamine transforms the emotional significance of a novel but not a familiar environment: implications for addiction

Acute and chronic ethanol differentially modify the emotional significance of a novel environment: implications for addiction

Systemic Administration of Arecoline Reduces Ethanol‐Induced Sleeping Through Activation of Central Muscarinic Receptor in Mice

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