Ethanol‐free extraction of resveratrol and its glycoside from Japanese knotweed rhizome by liquefied dimethyl ether without pretreatments

Abstract

Herein, we carried out the extraction of polyphenol resveratrol and its glycoside (piceid) from raw Japanese knotweed via a simple method, employing dimethyl ether (DME) as the solvent. With DME extraction, the conventional drying and cell wall disruption steps can be left out. As a result, more resveratrol and piceid were obtained in DME extraction than in conventional ethanol extraction. Because the Hansen solubility parameters of DME are closer to ethanol than to water, it allowed us to extract resveratrol and piceid from raw Japanese knotweed, unlike water. Simultaneously, 83.5% of the initial water and 213 mg/g dry of organic extracts were extracted from raw Japanese knotweed. As DME extraction does not involve drying and grinding of the decomposed antioxidants, it is highly suitable for extracting antioxidants.

UHPLC Analysis of Reynoutria japonica Houtt. Rhizome Preparations Regarding Stilbene and Anthranoid Composition and Their Antimycobacterial Activity Evaluation

“…Absolute stilbene content amounted to 155.078 mg/100 g fluid extract ( Table 4 ) and could easily be improved through scale-up processes like large batch processing and concentration of constituents by evaporation of solvent. A stilbene extraction from fresh R. japonica rhizome with liquified dimethyl ether was reported to yield 0.342 mg/g resveratrol and 2.57 mg/g polydatin, calculated per gram of dry rhizome [ 25 ]. Extraction of resveratrol from dried and pulverized R. japonica rhizome with deep eutectic solvents (DES) yielded up to 9.00 mg/g dry rhizome [ 26 ].…”

Preparation of Liposomes from Soy Lecithin Using Liquefied Dimethyl Ether

“…Additionally, previous studies have shown that liquefied DME can extract a variety of functional substances, such as astaxanthin [50,51], fucoxanthin [52], lutein [29,53], resveratrol and its glycosides [54], catechins and caffeine [55], tocopherol [56], gingerols and capsaicin [27]. Among these substances, carotenoids, such as astaxanthin, fucoxanthin and lutein, are hydrophobic, therefore difficult to encapsulate into liposomes by mechanical methods.…”

Enhancement of Lipid Extraction from Soya Bean by Addition of Dimethyl Ether as Entrainer into Supercritical Carbon Dioxide

“…In the HPS concept, the intermolecular interactions are classified into three components: δd (the energy from dispersion forces between molecules), δp (the energy from dipolar intermolecular forces between molecules), and δh (the energy from hydrogen bonds, π-π stacking interactions, coordination bonds, and charge transfer interactions), which are used to estimate the ease of mutual solubility. The δd, δp, and δh values for DME are 15.2 MPa 1/2 , 6.1 MPa 1/2 , and 5.7 MPa 1/2 [39], and those for CO 2 are 15.7 MPa 1/2 , 6.3 MPa 1/2 , and 5.7 MPa 1/2 [40]. The similarity of the properties of the extracts by SC-CO 2 extraction and SC-CO 2 with DME extraction is supported by the HPS concept that solutes are readily soluble in solvents that have similar three-dimensional vectors of HPS parameters [41].…”