Ethanol Extract of Myrtle (Myrtus communis L.) Berries as a Remedy for Streptozotocin-Induced Oxidative Stress in Rats

Ağgül, Ahmet Gökhan; Demir, Galip Mesut; Gülaboğlu, Mine

doi:10.1007/s12010-021-03753-z

Cited by 11 publications

(9 citation statements)

References 49 publications

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“…One of berry extracts’ best-known actions is their antioxidant effects [ 19 ]. Some studies have highlighted their inhibitory activity against enzymes linked to neurodegenerative diseases [ 20 ], beneficial effects on gastrointestinal disorders [ 21 , 22 , 23 ], ability to reduce streptozotocin-induced oxidative stress in diabetic rats [ 24 ], and wound-healing properties [ 25 ]. These properties can all be related to myrtle extract’s antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

Liposomal Formulations to Improve Antioxidant Power of Myrtle Berry Extract for Potential Skin Application

et al. 2022

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Many substances in plant extracts are known for their biological activities. These substances act in different ways, exerting overall protective effects against many diseases, especially skin disorders. However, plant extracts’ health benefits are often limited by low bioavailability. To overcome these limitations, drug delivery systems can be employed. In this study, we evaluated the antioxidant power of an ethanolic extract from Myrtus communis L. (myrtle) berries through colorimetric tests (DPPH and FRAP). The antioxidant activity was also verified by using fibroblast cell culture through cellular Reactive Oxygen Species (ROS) levels measurements. Moreover, the myrtle extract was formulated in phospholipid vesicles to improve its bioavailability and applicability. Myrtle liposomes were characterized by size, surface charge, storage stability, and entrapment efficiency; visualized by using cryo-TEM images; and assayed for cytocompatibility and anti-ROS activity. Our results suggest that myrtle liposomes were cytocompatible and improved the extract’s antioxidant power in fibroblasts, suggesting a potential skin application for these formulations and confirming that nanotechnologies could be a valid tool to enhance plant extracts’ potentialities.

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Section: Introductionmentioning

confidence: 99%

Liposomal Formulations to Improve Antioxidant Power of Myrtle Berry Extract for Potential Skin Application

et al. 2022

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“…Utilizing weight-loss inhibitors is one of the strategies employed in the research for anti-diabetes drugs. 36 p-Synephrine administration also markedly altered the liver index, kidney index, pancreas index, spleen index and interscapular brown adipose tissue index. MET, which served as a positive control in the present study, is a first-line clinical diabetes treatment pharmaceutical.…”

Section: Papermentioning

confidence: 88%

p-Synephrine ameliorates alloxan-induced diabetes mellitus through inhibiting oxidative stress and inflammation via suppressing the NF-kappa B and MAPK pathways

et al. 2023

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“…The current study revealed that MDA value was a marked increased while SOD and GSH values were significantly decreased in diabetic group after 30 days of receiving STZ which indicated oxidative stress. The elevated level of MDA and decrease level of SOD and GSH may have been due to STZ inducing hyperglycemia and causes tissue damage through increasing the lipid peroxidation by-products and decrease the level of antioxidants (Aggul et al 2022 ). On the other side, there was a significant decrease in the level of MDA and significant increase in the level of SOD and GSH when diabetic rats treated with quercetin.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of quercetin on pulmonary dysfunction in streptozotocin-induced diabetic rats via inhibition of NLRP3 signaling pathway

El-Shaer

Hegazy

Muhammad

2023

Environ Sci Pollut Res

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Diabetes mellitus (DM) is a dysmetabolic disease characterized by chronic hyperglycemia. In the developed countries, DM is the commonest life style disease that affects both old and young age. Nod-like receptor protein-3 (NLRP3)-mediated pyroptosis may in fact aid in the development of diabetic complications. Quercetin is a natural flavonoid, can be present in natural foods and plants. Many studies have reported the antioxidant role of quercetin on different tissues, but its effects on NLRP3-mediated pyroptosis in diabetic lung are unclear. The current study aimed to assess quercetin’s protective effects on lung function, oxidative stress, and NLRP3-mediated pyroptosis in Wister rats exposed to streptozotocin (STZ)-induced DM. Forty male Wister rats were randomly allocated into four equal groups. The groups of rats were as follows: group 1 (G1) was kept under normal control conditions; G2 was injected I/P quercetin at a dose of 30 mg/kg b.wt., daily for 30 days; G3 and G4 were injected with a single dose of streptozotocin (STZ) 50 mg/kg b.wt. I/P to induce DM. After 72-h post diabetes induction, the rats of G4 were treated with quercetin as a manner in the second group. The results showed that quercetin ameliorates the pulmonary dysfunctions caused by DM through restoring the levels of glucose, insulin, and arterial blood gases, as well as the oxidative markers. Also, NLRP3-pyroptosis-mediated IL1β was inhibited. Quercetin also reduces the effect of DM on the lung by decreasing the pathological changes in the lung. In conclusion, NLRP3 inflammasome-induced pyroptosis may aggravate lung injury in diabetic rats. Quercetin has the potential to ameliorate diabetes induced pulmonary dysfunction by targeting NLRP3.

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Ethanol Extract of Myrtle (Myrtus communis L.) Berries as a Remedy for Streptozotocin-Induced Oxidative Stress in Rats

Cited by 11 publications

References 49 publications

Liposomal Formulations to Improve Antioxidant Power of Myrtle Berry Extract for Potential Skin Application

Liposomal Formulations to Improve Antioxidant Power of Myrtle Berry Extract for Potential Skin Application

p-Synephrine ameliorates alloxan-induced diabetes mellitus through inhibiting oxidative stress and inflammation via suppressing the NF-kappa B and MAPK pathways

Protective effect of quercetin on pulmonary dysfunction in streptozotocin-induced diabetic rats via inhibition of NLRP3 signaling pathway

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