2023
DOI: 10.21203/rs.3.rs-3545438/v1
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Ethanol extract of Alpiniae oxyphyllae fructus regulates glucose metabolism, the HPA axis and hippocampal function in diabetic mice with depression

Qilun Zhou,
Yue Qi,
Jinlan Deng
et al.

Abstract: Background: Alpiniae oxyphyllae fructus (AOF) is the dry ripe fruit of Alpinia oxyphylla Miq. which has significant therapeutic effects in Alzheimer's disease, Parkinson's disease, depression, learning and memory dysfunction and other nervous system disease. Methods: In this study, we established a mouse model of Type 2 Diabetes Mellitus (T2DM) combined with depression induced by feeding high fat and high sugar diet combined with intraperitoneal injection of streptozotocin (STZ) and chronic unpredictable mild … Show more

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