Ethanol Exacerbates Hepatic Microvascular Dysfunction, Endotoxemia, and Lethality in Septic Mice

The hepatic circulation in health and disease: Report of a single-topic symposium

“…This inflammatory response is augmented by the concomitant development of sepsis and endotoxemia. 105 The administration of anti-TNF antibody blocks the effects of ethanol, suggesting that TNF-␣ release from KC may also mediate the inflammatory effects of ethanol in the microcirculation. Recent studies indicating that endotoxin circulates in the blood of patients with alcoholic liver disease suggest that these mechanisms may have relevance to the pathogenesis of alcoholic liver disease.…”

Ethanol Binging Enhances Hepatic Microvascular Responses to Acetaminophen in Mice

“…In addition, acute ethanol ingestion in rats prior to liver transplantation disturbs the microcirculation in grafts, resulting in poor survival rate after transplantation (28). Acutely administered ethanol also exacerbates liver microcirculatory dysfunction in the presence of sepsis in mice (20).…”

Littoral cell angioma of the spleen diagnosed by endoscopic ultrasound‐guided fine‐needle aspiration biopsy

“…In alcoholic liver injury, ethanol‐induced perturbation of microcirculation has been extensively studied in association with endotoxins, Kupffer cell activation, endothelium‐derived factors, and leukocyte adhesion to sinusoidal endothelial cells (SECs) 1–5. The structural and functional alterations of sinusoidal endothelial fenestrae also have been reported to involve impaired microcirculatory exchange of fluids and solutes between the sinusoidal lumen and the space of Disse 6, 7.…”