Ethanol effects on impulsivity in two mouse strains: similarities to diazepam and ketamine

Abstract

Ethanol's ability to increase impulsivity in the 5-CSRTT is mediated by both common and different neurotransmitter systems in the two strains of mice and is dependent on the task's parameters. Furthermore, ethanol did not decrease response accuracy, suggesting that attentional mechanisms are preserved after acute ethanol in mice and that the increases in impulsive behaviour are independent of attentional performance.

High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress

“…Previous studies in normal healthy volunteers indicate that diazepam produces behavioural disinhibition by reducing the threshold for a response without affecting delay-discounting or risk-taking (Acheson et al 2006;Deakin et al 2004). Consistent with these findings, diazepam significantly increased premature responding on the 5-CSRTT in mice (Oliver et al 2009). Our failure to replicate this finding in rats presumably relates to species differences and the selection of extreme impulsivity phenotypes in the present study.…”

Learning not to be impulsive: disruption by experience of alcohol withdrawal

“…Like Bizarro et al, we found no effects of ethanol on impulsive responding in well-trained mice (Oliver et al 2009). Nevertheless, we found effects of ethanol in two mouse strains in the 5CSRTT when well-trained mice were exposed to occasional sessions in which the intertrial interval (ITI) was extended from 5 to 7 s. In the present experiment, we used a further modification of the task, introducing occasional test sessions in which the ITI was varied within the session at 2, 5, 10 and 15 s, to provide a parametric study of the effects of changes in ITI.…”

“…When the animal produced two consecutive sessions achieving the performance criteria (shown in Table 1), the stimulus duration was reduced in the following pattern: 30, 20, 10, 5, 2.5, 1.8, and the LH and the ITI were set at 5 s, following Oliver et al (2009). Testing was carried out daily (5-6 days a week), and the session lasted for 100 trials or 30 min, whichever came first.…”

The influence of test experience and NK1 receptor antagonists on the performance of NK1R-/- and wild type mice in the 5-Choice Serial Reaction-Time Task

“…The procedure is based on that developed by Oliver et al (2009) and is described fully in Yan et al (2011). The schedule for training and testing of the mice is illustrated in Figure 1.…”