Ethanol Content Determination in Medicine Syrups Using Headspace and Multidimensional Heart-Cut Gas Chromatography Coupled to Mass Spectrometry

Abstract

Despite the efforts of the pharmaceutical industry to reduce the ethanol content in medicines, many of these products are still commercially available. These medicines must be monitored by quality control techniques using accurate method. Therefore, this study proposes to develop and validate an analytical method for ethanol quantification in adult and pediatric syrups, in order to guarantee the safety of medication certificates. For this, headspace multidimensional gas chromatography (heart-cut) coupled to mass spectrometry (HS-MDGC/MS) was used. The method was validated according to the norm established by National Agency of Sanitary Surveillance (ANVISA) presenting limit of detection (LOD) of 0.03% (v/v) and limit of quantification (LOQ) of 0.06% (v/v) ethanol, excellent selectivity and the recovery values (accuracy) were between 96.71 and 101.38%. Ethanol concentrations in commercial medicines syrups varied from 0.06 to 8.83%, which makes evident the need to control the syrup producing industries.

Characterization and Optimization of Phytosome Formulation Containing Alcohol-free Umckalin from Pelargonium sidoides

“…extract containing umckalin includes approximately 11 % ethanol in traditional and medicinal products (Wopker et al, 2020). However, ethanol containing products are reported as hazardous for infants and children (Batista et al, 2020). The extraction with the solvent mixture containing ethanol free was defined, thus obtaining a liquid preparation that provides a convenient use for children (Kohnen, 2007).…”

Rapid Estimation of Ethanol Concentration using Acousto‐Optic Diffraction

“…Accurate estimation of ethanol concentration is required in alcohol industries to optimize and regulate the fermentation process for increasing yields and quality of products. [1] The same is necessary in medical institutions [2,3] and fuel industries, [4][5][6] where the concentrations of ethanol need to be adjusted in different solutions depending on their applications. Ethanol is also used widely in cosmetics, [7] and perfumery [8] as preservative agent and carrier of fragrances.…”