Ethanol conditioned place preference and alterations in ΔFosB following adolescent nicotine administration differ in rats exhibiting high or low behavioral reactivity to a novel environment

Philpot, Rex M.; Engberg, M.E.; Wecker, Lynn

doi:10.1016/j.bbr.2013.12.014

Cited by 4 publications

(4 citation statements)

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“…Individual differences may also underlie such discrepancies, since a prior study has shown that adolescent rats with high behavioral reactivity in a novel environment that are exposed to nicotine develop conditioned place preference to ethanol as adults, whereas low behavioral activity animals do not (141). In addition, concurrent acetaldehyde, the primary metabolite of ethanol, increases initial acquisition of nicotine self-administration in adolescent male rats (142).…”

Section: Concurrent Use Of Nicotine and Alcoholmentioning

confidence: 99%

Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse

Cross

Lotfipour

Leslie

2016

The American Journal of Drug and Alcohol Abuse

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Concurrent use of tobacco and alcohol or psychostimulants represents a major public health concern, with use of one substance influencing consumption of the other. Co-abuse of these drugs leads to substantial negative health outcomes, reduced cessation, and high economic costs, but the underlying mechanisms are poorly understood. Epidemiological data suggest that tobacco use during adolescence plays a particularly significant role. Adolescence is a sensitive period of development marked by major neurobiological maturation of brain regions critical for reward processing, learning and memory, and executive function. Nicotine exposure during this time produces a unique and long-lasting vulnerability to subsequent substance use, likely via actions at cholinergic, dopaminergic, and serotonergic systems. In this review, we discuss recent clinical and preclinical data examining the genetic factors and mechanisms underlying co-use of nicotine and alcohol or cocaine and amphetamines. We evaluate the critical role of nicotinic acetylcholine receptors throughout, and emphasize the dearth of preclinical studies assessing concurrent drug exposure. We stress important age and sex differences in drug responses, and highlight a brief, low-dose nicotine exposure paradigm that may better model early use of tobacco products. The escalating use of e-cigarettes among youth necessitates a closer look at the consequences of early adolescent nicotine exposure on subsequent alcohol and drug abuse.

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Section: Concurrent Use Of Nicotine and Alcoholmentioning

confidence: 99%

Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse

Cross

Lotfipour

Leslie

2016

The American Journal of Drug and Alcohol Abuse

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“…Very few indications are given by experimenters as to why one procedure is chosen over another. However, all of the foregoing methods of adolescent nicotine exposure in rats have been shown to cause neural and behavioral changes that last into adulthood (Abreu-Villaça et al, 2003a; Abreu-Villaça et al, 2003b; Adriani, Spijker, Deroche-Gamonet, Laviola, Le Moal, Smit, & Piazza, 2003; Barron, White, Swartzwelder, Bell, Rodd, Slawecki, Ehlers, Levin, Rezvani, & Spear, 2005; Belluzzi, Lee, Oliff, & Leslie, 2004; Brielmaier, McDonald, & Smith, 2007; Counotte et al, 2009; Dwyer, McQuown, & Leslie, 2009; Fountain et al, 2008; McDonald, Dailey, Bergstrom, Wheeler, Eppolito, Smith, & Smith, 2005; Natividad, Torres, Friedman, & O'Dell, 2013; Philpot, Engberg, & Wecker, 2014; Pickens et al, 2013; Polesskaya, Fryxell, Merchant, Locklear, Ker, McDonald, Eppolito, Smith, Wheeler, & Smith, 2007; Quick, Olausson, Addy, & Taylor, 2014; Schochet et al, 2004; Slawecki et al, 2004; Slotkin, 2002; Slotkin, Bodwell, Ryde, & Seidler, 2008; Slotkin, MacKillop, Rudder, Ryde, Tate, & Seidler, 2007; Spaeth et al, 2010; Trauth, McCook, Seidler, & Slotkin, 2000; Trauth, Seidler, McCook, & Slotkin, 1999; Trauth, Seidler, & Slotkin, 2000a, 2000b; Wheeler, Smith, Bachus, McDonald, Fryxell, & Smith, 2013). Furthermore, recent research has found that various forms of stress in adolescence can have long-term effects on cognition (Green & McCormick, 2013; Isgor, Kabbaj, Akil, & Watson, 2004; Morrissey, Mathews, & McCormick, 2011; Torregrossa, Xie, & Taylor, 2012).…”

Section: Introductionmentioning

confidence: 99%

Paradoxical effects of injection stress and nicotine exposure experienced during adolescence on learning in a serial multiple choice (SMC) task in adult female rats

Renaud

Pickens

Fountain

2015

Neurotoxicology and Teratology

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Nicotine exposure in adolescent rats has been shown to cause learning impairments that persist into adulthood long after nicotine exposure has ended. This study was designed to assess the extent to which the effects of adolescent nicotine exposure on learning in adulthood can be accounted for by adolescent injection stress experienced concurrently with adolescent nicotine exposure. Female rats received either 0.033 mg/hr nicotine (expressed as the weight of the free base) or bacteriostatic water vehicle by osmotic pump infusion on postnatal days 25-53 (P25-53). Half of the nicotine-exposed rats and half of the vehicle rats also received twice-daily injection stress consisting of intraperitoneal saline injections on P26-53. Together these procedures produced 4 groups: No Nicotine / No Stress, Nicotine / No Stress, No Nicotine / Stress, and Nicotine / Stress. On P65-99, rats were trained to perform a structurally complex 24-element serial pattern of responses in the serial multiple choice (SMC) task. Four general results were obtained in the current study. First, learning for within-chunk elements was not affected by either adolescent nicotine exposure, consistent with past work (Pickens, Rowan, Bevins, & Fountain, 2013), or adolescent injection stress. Thus, there were no effects of adolescent nicotine exposure or injection stress on adult within-chunk learning typically attributed to rule learning in the SMC task. Second, adolescent injection stress alone (i.e., without concurrent nicotine exposure) caused transient but significant facilitation of adult learning restricted to a single element of the 24-element pattern, namely, the “violation element,” that was the only element of the pattern that was inconsistent with pattern structure. Thus, adolescent injection stress alone facilitated violation element acquisition in adulthood. Third, also consistent with past work (Pickens et al., 2013), adolescent nicotine exposure, in this case both with and without adolescent injection stress, caused a learning impairment in adulthood for the violation element in female rats. Thus, adolescent nicotine impaired adult violation element learning typically attributed to multiple-item learning in the SMC task. Fourth, a paradoxical interaction of injection stress and nicotine exposure in acquisition was observed. In the same female rats in which violation-element learning was impaired by adolescent nicotine exposure, adolescent nicotine experienced without adolescent injection stress produced better learning for chunk-boundary elements in adulthood compared to all other conditions. Thus, adolescent nicotine without concurrent injection stress facilitated adult chunk-boundary element learning typically attributed to concurrent stimulus-response discrimination learning and serial-position learning in the SMC task. To the best of our knowledge, the current study is the first to demonstrate facilitation of adult learning caused by adolescent nicotine exposure.

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“…100 Regarding β4β2★ receptors, a recent study revealed that chronic ethanol exposure/intake, including in utero exposure, by rhesus monkeys significantly decreased β4β2★ levels in the frontal and insular cortex. 101 In a study involving in utero exposure of rats, it was found that gestational exposure to ethanol and nicotine significantly increased nicotine self-administration during adolescence, and this effect seemed to be due to glutamatergic modulation of the mesolimbic-dopamine system.…”

Section: Alcohol Nicotine Coabuse and Nachrsmentioning

confidence: 99%

Recent Advances in Nicotinic Receptor Signaling in Alcohol Abuse and Alcoholism

Rahman

Engleman

Bell

2016

Progress in Molecular Biology and Translational Science

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Alcohol is the most commonly abused legal substance and alcoholism is a serious public health problem. It is a leading cause of preventable death in the world. The cellular and molecular mechanisms of alcohol reward and addiction are still not well understood. Emerging evidence indicates that unlike other drugs of abuse, such as nicotine, cocaine, or opioids, alcohol targets numerous channel proteins, receptor molecules, and signaling pathways in the brain. Previously, research has identified brain nicotinic acetylcholine receptors (nAChRs), a heterogeneous family of pentameric ligand-gated cation channels expressed in the mammalian brain, as critical molecular targets for alcohol abuse and dependence. Genetic variations encoding nAChR subunits have been shown to increase the vulnerability to develop alcohol dependence. Here, we review recent insights into the rewarding effects of alcohol, as they pertain to different nAChR subtypes, associated signaling molecules, and pathways that contribute to the molecular mechanisms of alcoholism and/or comorbid brain disorders. Understanding these cellular changes and molecular underpinnings may be useful for the advancement of brain nicotinic–cholinergic mechanisms, and will lead to a better translational and therapeutic outcome for alcoholism and/or comorbid conditions.

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Ethanol conditioned place preference and alterations in ΔFosB following adolescent nicotine administration differ in rats exhibiting high or low behavioral reactivity to a novel environment

Cited by 4 publications

References 60 publications

Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse

Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse

Paradoxical effects of injection stress and nicotine exposure experienced during adolescence on learning in a serial multiple choice (SMC) task in adult female rats

Recent Advances in Nicotinic Receptor Signaling in Alcohol Abuse and Alcoholism

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