Ethanol and Δ-sleep-inducing peptide: Effects on brain monoamines

Yukhananov, R. Yu.; Tennilä, Tuula; Miroshnicenko, T.I.; Кудрин, В. С.; Ushakov, A. N.; Mel'nik, E. I.; Michaleva, I.I.; Rayevsky, K.S.; Airaksinen, Mauno M.; Maisky, A. I.

doi:10.1016/0091-3057(92)90396-w

Cited by 10 publications

(3 citation statements)

References 16 publications

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“…Recently, Strafella et al (2001) showed that 10-Hz high-frequency rTMS of the prefrontal cortex induces the release of endogenous dopamine from subcortical nuclei. Further, alcohol may change the function of serotonin (Yukhananov et al, 1992). Prefrontal TMS may modify the function of serotonin (Gur et al, 2000).…”

Section: Neuropsychopharmacologymentioning

confidence: 99%

Alcohol Reduces Prefrontal Cortical Excitability in Humans: A Combined TMS and EEG Study

Kähkönen

Wilenius

Nikulin

et al. 2002

Neuropsychopharmacol

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The effects of alcohol (0.8 g/kg) on the prefrontal cortex were studied in nine healthy subjects using the technique of transcranial magnetic stimulation (TMS) combined with electroencephalography (EEG). A total of 120 magnetic pulses were delivered with a figureof-eight coil to the left prefrontal cortex at the rate of 0.4-0.7 Hz. The EEG was recorded simultaneously with 60 scalp electrodes (41 electrodes were used for analysis); the TMS-evoked activation was estimated by the area under the global mean field amplitude (GMFA) time curve. TMS caused changes in EEG activity lasting up to 270 ms poststimulus. Alcohol decreased GMFA at 30-270 ms poststimulus (713 7 303 vs 478 7 142 mV ms; p ¼ 0.007). Alcohol-induced differences were most pronounced at anterior electrodes. These results suggest that alcohol reduces the excitability in the prefrontal cortex.

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Section: Neuropsychopharmacologymentioning

confidence: 99%

Alcohol Reduces Prefrontal Cortical Excitability in Humans: A Combined TMS and EEG Study

Kähkönen

Wilenius

Nikulin

et al. 2002

Neuropsychopharmacol

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“…1995; Vgontzas et al . 1995); anti‐opioid and anti‐alcohol activity (DSIP can suppress the development of alcohol and opiate dependency this being the basis for DSIP clinical application; Yukhananov et al . 1991, 1992; Soyka and Rothenhaeusler 1997; Backmund et al .…”

Section: Structure Of Delta Sleep‐inducing Peptide (Dsip) and Dermorpmentioning

confidence: 99%

Delta sleep‐inducing peptide (DSIP): a still unresolved riddle

Kovalzon

Strekalova

2006

Journal of Neurochemistry

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Delta sleep-inducing peptide (DSIP) was isolated from rabbit cerebral venous blood by Schoenenberger-Monnier group from Basel in 1977 and initially regarded as a candidate sleep-promoting factor. However, the link between DSIP and sleep has never been further characterized, in part because of the lack of isolation of the DSIP gene, protein and possible related receptor. Thus the hypothesis regarding DSIP as a sleep factor is extremely poorly documented and still weak. Although DSIP itself presented a focus of study for a number of researchers, its natural occurrence and biological activity still remains obscure. DSIP structure is different from any other known representative of the various peptide families. In this mini-review we hypothesize the existence of a DSIP-like peptide(s) that is responsible (at least partly) for DSIP-like immunoreactivity and DSIP biological activity. This assumption is based on: (i) a highly specific distribution of DSIP-like immunoreactivity in the neurosecretory hypothalamic nuclei of various vertebrate species that are not particularly relevant for sleep regulation, as revealed by the histochemical studies of the Geneva group (Charnay et al.); (ii) a large spectrum of DSIP biological activity revealed by biochemical and physiological studies in vitro; (iii) significant slow-wave sleep (SWS) promoting activity of certain artificial DSIP structural analogues (but not DSIP itself!) in rabbits and rats revealed by our early studies; and (iv) significant SWS-promoting activity of a naturally occurring dermorphin-decapeptide that is structurally similar to DSIP (in five of the nine positions) and the sleep-suppressing effect of its optical isomer, as revealed in rabbits. Potential future studies are outlined, including natural synthesis and release of this DSIP-like peptide and its role in neuroendocrine regulation.

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“…Alcohol and its effects on the brain have been intensely studied in humans and animals. Alcohol is initially tiring and induces slow wave sleep when ethanol-enhanced gamma amino butyric acid (GABA) binds with its receptors [ 13 ]. As GABA disconnects from receptors and activates and deactivates monoamines, GABA has various effects on the sleep-wake cycle [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of nutrition and food on sleep—is there evidence?

Netzer,

Strohl,

Pramsohler

2023

Sleep Breath

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Background The influence of sleep disorders on metabolism, especially concerning obesity and diabetes, as well as obesity and obstructive sleep apnea, has been widely investigated. However, the effect of nutrition and the intake of certain foods on sleep has only recently gained attention. In recent years, there have been publications on intake of certain foods and certain diets regarding their influence on sleep, as well as activity of adipocytes and their effect on production of sleep hormones. Methods Following PRISMA guidelines, we performed a PubMed search using the key words “sleep,” “sleep disorders,” “nutrition,” “food,” and “food intake” published from 2012 to 2022. We excluded by consensus all articles with diets and exercise programs or bariatric surgery for weight loss to treat sleep apnea, all articles on connections between sleep disorders and metabolic disorders, and articles concerning the influence of drugs on neuroactive substances. Results Of the 4155 publications revealed, 988 had nutrition, metabolism, and sleep as the primary topic of research. Of these 988 publications, only 26 fulfilled the content requirements concerning the influence of certain food and diets on sleep or sleep disorders, including the influence of the gastrointestinal system and adipocytes on sleep hormones. None of the investigations revealed clear evidence of an effect of a certain diet or food on sleep. Epidemiologic surveys suggest that shortened or fragmented sleep and chronotype in adults influence nutrition and fat metabolism. Additionally, there is evidence that adipocyte signaling influences neuronal mediators and hormones of the sleep-wake cycle. Conclusion There is no evidence of a direct influence of certain nutrition or food intake on sleep. Obesity via adipocyte signaling may influence the sleep-wake cycle, though the molecular research on this topic is based on animal studies.

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Ethanol and Δ-sleep-inducing peptide: Effects on brain monoamines

Cited by 10 publications

References 16 publications

Alcohol Reduces Prefrontal Cortical Excitability in Humans: A Combined TMS and EEG Study

Alcohol Reduces Prefrontal Cortical Excitability in Humans: A Combined TMS and EEG Study

Delta sleep‐inducing peptide (DSIP): a still unresolved riddle

Influence of nutrition and food on sleep—is there evidence?

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