Ethanol and Cognition: Indirect Effects, Neurotoxicity and Neuroprotection: A Review

Brust, John C.M.

doi:10.3390/ijerph7041540

Cited by 202 publications

(139 citation statements)

References 148 publications

(161 reference statements)

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“…Globally, alcoholism is the world's fifth leading cause of death [86] and is the leading risk factor for premature death and disability [87]. Alcoholics experience a number of cognitive deficiencies such as learning and memory deficiencies, impairment of decisionmaking and problems with motor skills, as well as suffering behavioural changes that include anxiety and depression [88,89].…”

Section: Alcoholism Related-disorders Diagnosismentioning

confidence: 99%

Medical Big Data: Neurological Diseases Diagnosis Through Medical Data Analysis

2016

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Section: Alcoholism Related-disorders Diagnosismentioning

confidence: 99%

Medical Big Data: Neurological Diseases Diagnosis Through Medical Data Analysis

2016

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“…Alcohol acts directly and indirectly on the central nervous system [14,16,115] and alcohol abuse causes cognitive impairment.…”

Section: Introductionmentioning

confidence: 99%

Wine consumption, cognitive function and dementias – A relationship?

Stockley

2016

NUA

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Abstract. Healthy cognitive function is essential for quality of life, wellbeing and independent living, and is negatively associated with dementias. A series of longitudinal and neuro-imaging studies in the elderly have shown that light to moderate wine consumption is neuro-protective although heavy or abusive alcohol consumption is neuro-toxic. A J-shaped relationship between alcohol consumption, cognitive dysfunction and risk of dementias is also observed for younger and middle aged consumers. There is also no data to suggest that long-term light to moderate alcohol consumption exacerbates age-related cognitive decline and impairment. An optimal amount of wine for neuro-protection appears to be up to 30 g alcohol daily.There are multiple plausible biological mechanisms in various animal models, in vitro and in vivo for wine-derived phenolic compounds which go beyond their antioxidant activity and attenuation of oxidative stress.

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“…Alcohol is a macronutrient that can interfere with the cognitive functioning of the individual when consumed (Brust, 2010;Weissenborn & Duka, 2003). Alcohol influences human behavior by increasing and decreasing brain activity in different brain regions and by changing brain's functional organization (Volkow et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

The effect of alcohol on the nature of lexical representations in different taste domains

Baskini¹,

Proios²

2016

Psychol. Thought

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Moderate alcohol consumption may be involved in cognitive feedback mechanisms (Hofmann & Friese, 2008), participants execute verbal fluency test (VFT) better (Cerhan et al., 1998) and there is positive association between sweet taste and excessive alcohol intake (Lange, Kampov-Polevoy, & Garbutt, 2010). We investigate the immediate pharmacological consequences of moderate to light alcohol consumption in verbal fluency and categorical sorting within the different taste domains (i.e. sweet, salty, sour and bitter). Our hypothesis is that subjects under the influence of light to moderate alcohol will produce more items in the sweet domain. 53 healthy adults had moderate alcohol consumption and were compared in two semantic tasks to 53 adults, who did not drink alcohol. Mann-Whitney U tests showed that the total number of clusters, switches, and repetitions were equal between the two groups in all taste domains (p-values: .211, .401, and .684 respectively). The number of responses in the alcohol group generated more disinhibiting intrusive words during the VFTs as compared to the control group (p-value: <.001). VFTs and the order of taste preference in the card-sorting task showed positive correlation and agreement. Light to moderate alcohol did not affect verbal fluency. However, participants under the influence of alcohol generated significantly more errors in the VFTs that were emotionally laden. This corroborates with research that certain emotions are innervated with taste domains. This leaves open question about the effects of alcohol on decision making in eating and executive functions as they relate to lexical representations.

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Ethanol and Cognition: Indirect Effects, Neurotoxicity and Neuroprotection: A Review

Cited by 202 publications

References 148 publications

Medical Big Data: Neurological Diseases Diagnosis Through Medical Data Analysis

Medical Big Data: Neurological Diseases Diagnosis Through Medical Data Analysis

Wine consumption, cognitive function and dementias – A relationship?

The effect of alcohol on the nature of lexical representations in different taste domains

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