Ethamsylate Protects Against the Carbon Tetrachloride-Induced Liver Damage in Rats

Abstract

Ethamsylate is a synthetic haemostatic drug used for controlling capillary bleeding. In this study, the effect of ethamsylate on liver injury induced by acute carbon tetrachloride (CCl 4 ) administration in rats was investigated. Ethamsylate (45, 90 or 180 mg/kg) was given once daily orally simultaneously with CCl 4 and continued for 1 week thereafter. The extent of liver damage was determined by measuring serum activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) as well as by liver histopathology. Ethamsylate given at the above doses conferred significant hepatic protection against the CCl 4 -induced hepatotoxicity. It reduced serum ALT activities by 44.8%-70.9%, AST by 46.1%-51.4%, and ALP by 30.7%-48.5%, respectively, compared to the CCl 4 control group. Ethamsylate given at 90 mg/kg to CCl 4 -treated rats resulted in the preservation of the normal architecture of the liver tissue and no lymphocytic infiltration. These data indicate a beneficial effect for ethamsylate in the CCl 4 model of hepatotoxicity. Keywords:

Comparative Study Between Oxytocin Versus Tranexamic Acid And Ethamsylate To Reduce Blood Loss Intra-operative And Postoperative During Elective Cesarean Section

“…10 It likewise hinders bio-syntheses and activity on these prostaglandin products which as a reason for platelets separations, dilatation of the blood vessels and widened the permeability of the small vessels. 11 , It also facilitates platelet aggregation and adhesion which at last induce decrease and stop of hemorrhage. 12…”