Etching silver nanoparticles using DNA

Hu, Shengqiang; Yi, Tiantian; Huang, Zhicheng; Liu, Biwu; Wang, Jianxiu; Yi, Xinyao; Liu, Juewen

doi:10.1039/c8mh01126e

Cited by 40 publications

(32 citation statements)

References 59 publications

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“…[ 224 ] Depending on how the atoms are presented on the particle, AgNPs may also react with the DNA. [ 225,226 ] Since phosphate is a major component in the backbone of DNA, the AgNPs may react with these anionic bases, leading to structural alterations of the DNA potentially leading to changes in transcription and translation. [ 222 ] As a result, cell growth and replication may function abnormally, leading to less fit microorganism.…”

Section: Possible Mechanisms Of the Antimicrobial Activity Of Nanoparmentioning

confidence: 99%

Metal Nanoparticle–Microbe Interactions: Synthesis and Antimicrobial Effects

Khan

Fromm

Rizvi

et al. 2020

Part & Part Syst Charact

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metal solution, reduction of the metal ions leads to the generation of metal atom clustering generating nanosized particles. A characteristic of biosynthetic NPs is their high stability as the organisms provide their own biomolecular capping agent(s). [1] While plant-based production of NPs is now considered a scientific curiosity rather than a promising biotechnology, [2] bacteriamediated NP biosynthesis offers better chances, in light of the poorly characterized microbial diversity and the complex chemistry of enzymes in metal-reducing bacteria. Two recent works focused on directed biofabrication of CdSe-nanoparticles through regulating extracellular electron transfer [3] and the biosynthesis of highly active copper NPs (CuNP) by Shewanella oneidensis. [4] However, the description of molecular mechanism(s) involved in the biosynthesis of NPs has received little attention, which is the focus of this review.The CFCF or culture supernatants (CS) of bacteria mediate the synthesis of AgNPs [5] as presented in this section. The CFCF from the family Enterobacteriaceae reduce silver ions to AgNPs ( Table 1). CFCF of Klebsiella pneumoniae, Escherichia coli, and Metal nanoparticles (NPs), chalcogenides, and carbon quantum dots can be easily synthesized from whole microorganisms (fungi and bacteria) and cell-free sterile filtered spent medium. The particle size distribution and the biosynthesis time can be somewhat controlled through the biomass/metal solution ratio. The biosynthetic mechanism can be explained through the ionreduction theory and UV photoconversion theory. Formation of biosynthetic NPs is part of the detoxification strategy employed by microorganisms, either in planktonic or biofilm form, to reduce the chemical toxicity of metal ions. In fact, most reports on NP biosynthesis show extracellular metal ion reduction. This is important for environmental and industrial applications, particularly in biofilms, as it allows in principle high biosynthetic rates. The antimicrobial and antifungal effect on biosynthetic NPs can be explained in terms of reactive oxygen species and can be enhanced by the capping agents attached to the NP during the biosynthesis process. Industrial applications of NP biosynthesis are still lagging, due to the difficulty of controlling NP size and low titer. Further, the environmental assessment of biosynthetic NPs has not yet been carried out. It is expected that further advancements in biosynthetic NP research will lead to applications, particularly in environmental biotechnology.

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Section: Possible Mechanisms Of the Antimicrobial Activity Of Nanoparmentioning

confidence: 99%

Metal Nanoparticle–Microbe Interactions: Synthesis and Antimicrobial Effects

Khan

Fromm

Rizvi

et al. 2020

Part & Part Syst Charact

View full text Add to dashboard Cite

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“…However, the therapeutic application of silver nanoparticles is often limited by the physicochemical properties (e.g., size) and their aggregation-prone nature [ 29 , 115 , 116 ]. One strategy to address this was reported by Hu and coworkers via poly-cytosine DNA induced etching of silver nanoparticles [ 77 ]. Etching/dissolution of the silver nanoparticles was seen at low concentrations of the DNA whereas with increasing DNA, ripening was shown ( Figure 3 A,B).…”

Section: Nucleic Acid Hybrid Nanocarriersmentioning

confidence: 99%

“… ( A ) Schematic representation of etching and ripening stages of silver nanoparticles in the presence of poly-C DNA sequences. Reproduced with permission from [ 77 ]. Copyright Royal Society of Chemistry, 2019.…”

Section: Figurementioning

confidence: 99%

Nucleic Acid Hybrids as Advanced Antibacterial Nanocarriers

Obuobi

Škalko‐Basnet

2020

Pharmaceutics

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Conventional antibiotic therapy is often challenged by poor drug penetration/accumulation at infection sites and poses a significant burden to public health. Effective strategies to enhance the therapeutic efficacy of our existing arsenal include the use of nanoparticulate delivery platforms to improve drug targeting and minimize adverse effects. However, these nanocarriers are often challenged by poor loading efficiency, rapid release and inefficient targeting. Nucleic acid hybrid nanocarriers are nucleic acid nanosystems complexed or functionalized with organic or inorganic materials. Despite their immense potential in antimicrobial therapy, they are seldom utilized against pathogenic bacteria. With the emergence of antimicrobial resistance and the associated complex interplay of factors involved in antibiotic resistance, nucleic acid hybrids represent a unique opportunity to deliver antimicrobials against resistant pathogens and to target specific genes that control virulence or resistance. This review provides an unbiased overview on fabricating strategies for nucleic acid hybrids and addresses the challenges of pristine oligonucleotide nanocarriers. We report recent applications to enhance pathogen targeting, binding and control drug release. As multifunctional next-generational antimicrobials, the challenges and prospect of these nanocarriers are included.

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“…Electromagnetic waves excite the electrons of the NC, resulting in size‐dependent fluorescence emission . Among the DNA bases, cytosine has a stronger affinity to Ag + . Therefore, cytosine‐rich DNA was utilized for the preparation of DNA‐templated Ag NCs.…”

Section: Fluorescence‐/colorimetric‐based Biosensorsmentioning

confidence: 99%

“…[60,61] Among the DNA bases, cytosine has as tronger affinity to Ag + . [62] Therefore, cytosine-rich DNA was utilized for the preparation of DNA-templated Ag NCs. The probe DNA was composed of three domains:o ne part was cytosine-rich, another was the target recognition sequence, and the last part contained the blocking sequences, which were somewhat complementary to the cytosine-rich domain.…”

Section: Silver Nps As Af Luorescence Biosensormentioning

confidence: 99%

Strategies for the Development of Metallic‐Nanoparticle‐Based Label‐Free Biosensors and Their Biomedical Applications

et al. 2019

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Label‐free biosensors offer accurate sensing capabilities due to the reliable quantification of biological and biochemical processes. These devices function by establishing a dynamic interaction of analyte and receptor molecules and convert this interaction into a measurable signal through a transducer. In recent decades, label‐free biosensors have attracted attention in biomedical applications due to the ease of linking nanomaterials with bioreceptor molecules. In this review, recent advances in sensitivity, specificity, and sensing mechanism related to label‐free biosensors of metallic nanoparticles of gold, silver, aluminium, copper, and zinc oxide are presented. Selected sensing methods based on fluorescence, surface plasmon resonance, surface‐enhanced Raman scattering, metal‐enhanced fluorescence, and electrochemical sensors are discussed. New measurement techniques and rapid progress of label‐free biosensors are going to play a vital role in the real‐time detection of biomarkers in clinical samples, such as blood plasma, serum, and urine, as well as in targeted drug delivery. Future trends of these label‐free biosensing mechanisms and their development are also discussed.

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Etching silver nanoparticles using DNA

Abstract: Poly-C DNA is highly efficient in etching silver nanoparticles followed by Ostwald ripening at high DNA concentrations, increasing the toxicity of the nanoparticles.

Cited by 40 publications

References 59 publications

Metal Nanoparticle–Microbe Interactions: Synthesis and Antimicrobial Effects

Metal Nanoparticle–Microbe Interactions: Synthesis and Antimicrobial Effects

Nucleic Acid Hybrids as Advanced Antibacterial Nanocarriers

Strategies for the Development of Metallic‐Nanoparticle‐Based Label‐Free Biosensors and Their Biomedical Applications

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