État de stress post-traumatique : un levier thérapeutique

Waddington, Ashley; Zeltner, L.; Robin, Marion; Mauriac, Frédéric; Ampélas, Jean‐François; Bronchard, M.; Mallat, V.

doi:10.1016/s0013-7006(04)95444-9

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…It can often be complicated by somatic diseases such as ischemic heart illness, atherosclerosis, essential arterial hypertension, stroke, diabetes mellitus, metabolic syndrome, immunopathology, and even cancers [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. However, the primary symptoms of PTSD manifest as behavioral features, including hyperarousal, nightmares, flashbacks, anger, aggressiveness, fear, and anxiety [ 8 , 9 , 10 ]. The development of PTSD is associated with provoked stress time-dependent sensitization (TDS), which involves a series of neurobiological events with lasting consequences, including alterations in gene expression [ 11 , 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation

Tseilikman,

Shatilov,

Zhukov

et al. 2023

IJMS

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Currently, the efficacy of drug therapy for post-traumatic stress disorder or PTSD leaves much to be desired, making nutraceutical support a promising avenue for treatment. Recent research has identified the protective effects of resveratrol in PTSD. Here, we tested the behavioral and neurobiological effects of combining cheese consumption with resveratrol supplements in an experimental PTSD model. Using the elevated plus maze test, we observed that cheese intake resulted in a shift from anxiety-like behavior to depressive behavior, evident in increased freezing acts. However, no significant changes in the anxiety index value were observed. Interestingly, supplementation with cheese and resveratrol only led to the elimination of freezing behavior in half of the PTSD rats. We further segregated the rats into two groups based on freezing behavior: Freezing+ and Freezing0 phenotypes. Resveratrol ameliorated the abnormalities in Monoamine Oxidize -A and Brain-Derived Neurotrophic Factor gene expression in the hippocampus, but only in the Freezing0 rats. Moreover, a negative correlation was found between the number of freezing acts and the levels of Monoamine Oxidize-A and Brain-Derived Neurotrophic Factor mRNAs in the hippocampus. The study results show promise for resveratrol supplementation in PTSD treatment. Further research is warranted to better understand the underlying mechanisms and optimize the potential benefits of resveratrol supplementation for PTSD.

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