État de l’art de la photobiomodulation dans la prise en charge des effets secondaires de la radiothérapie : indications et niveaux de preuve

Klausner, G.; Bensadoun, René-Jean; Champion, Amber; Benzaquen, D.; Canova, C H; Claren, Audrey; Mancuso, V.; Suhl, J.; Balard, R.; Troussier, I.

doi:10.1016/j.canrad.2021.06.025

Cited by 4 publications

(3 citation statements)

References 65 publications

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“…The effectiveness of low-level LASER in the treatment of pain originating from soft tissue trauma, including those related to radiotherapy, can be attributed to the indirect reduction of edema, bleeding, neutrophilic activity, provocative cytokines and enzymatic action. This treatment modality reduces the characteristic pain observed more markedly in the three cases undergoing photobiomodulation therapy in this series, resulting in better tissue repair, as lymphatic vessel regeneration is accelerated [29,30].…”

Section: Effect Of Laser On Pain Reliefmentioning

confidence: 81%

Orofacial Myofunctional Therapy with and without Photobiomodulation in the Rehabilitation of Radiation-Induced Trismus: Case Series

Paim¹,

Goulart²,

Martins³

et al. 2022

IJCST

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Photobiomodulation (PBM) as a therapeutic technology is justified by the biochemical changes caused in the intracellular environment, such as increased production of adenosine triphosphate and activation of antioxidant enzymes, allowing early recovery and maintenance of the homeostasis and proper functioning. This case report aimed to describe the effect of orofacial myofunctional therapy associated or not with photobiomodulation in the rehabilitation of radio-induced trismus in 6 patients. Two intervention modalities were performed, with three patients undergoing OMT isolated and the other two subjects undergoing oral myofunctional therapy associated with photobiomodulation therapy (OMT+PBM). All participants completed the radiotherapy between 3 and 15 months before starting the trismus rehabilitation. The mouth opening was 21.00mm for the patients who underwent exclusive OMT and reached 30.25mm at the end of the rehabilitation (difference of 9.25mm), but for the other three patients submitted to OMT+PBM, it went from 8.4mm to 31.5mm (difference of 23,1mm). It was observed that patients who performed PBM+OMT had greater tolerance to the protocol exercises and less pain report. OMT+PBM was a good combination for trismus rehabilitation and could be considered in further randomized clinical trials.

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Section: Effect Of Laser On Pain Reliefmentioning

confidence: 81%

Orofacial Myofunctional Therapy with and without Photobiomodulation in the Rehabilitation of Radiation-Induced Trismus: Case Series

Paim¹,

Goulart²,

Martins³

et al. 2022

IJCST

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“…Based on these contradictory results, new randomized clinical trials are mandatory to answer these essential questions. 21,22 This study has limitations, such as the small sample size and the animal model choice. The rats showed some anatomical and histological specificities.…”

Section: Discussionmentioning

confidence: 99%

“…Based on these contradictory results, new randomized clinical trials are mandatory to answer these essential questions. 21,22…”

Section: Discussionmentioning

confidence: 99%

Effect of Photobiomodulation With Different Wavelengths on Radiodermatitis Treatment

Camargo

Forner-Cordero

Silva

et al. 2023

Plastic and Reconstructive Surgery - Global Open

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Background: Approximately 80% of patients submitted to radiotherapy develop radiodermatitis. Photobiomodulation based on light-emitted diode (LED) is one of the therapeutic strategies for treating inflammation. This study aimed to investigate the effect of the photobiomodulation with two wavelengths, in an acute radiodermatitis animal model. Methods: Twenty rats were submitted to one radiotherapy session. After 15 days, the rats that developed radiodermatitis were divided into control groups, LED-630 nm, LED-850 nm, and LED-630 + 850 nm. The treatment regimen was one session lasting 10 minutes on alternate days for 21 days. We analyzed macroscopy aspects (RTOG scale), vascular density, dermal appendages, VEGF-a, TNF-alpha, MMP-9, and MMP-9 genic expression level. Results: All LED groups revealed a two-point reduction on the radiodermatitis severity grade compared with the baseline classification. Dermal appendage and vascular analysis showed a higher counting in all LED groups compared to control. This study showed dermal appendages twice in the 630/850 nm group compared with the control group. The 630/850 nm group showed six times more arterioles than the control group. Regarding genic expression, this study showed a 10-fold decrease between LED-630 nm versus LED-630 + 850 nm ( P = 0.02) interleukin-10 expression and a 12-fold decrease between control versus LED-630 nm ( P = 0.006) and LED-850 nm ( P = 0.002) in TNF-alpha. Conclusion: LED (630 nm, 850 nm, and 630 nm + 850 nm) showed benefit in the treatment of radiodermatitis, and the association of the 630 nm + 850 nm and 630 nm parameters demonstrated the best macroscopic and microscopic results.

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Photobiomodulation dans la prévention et la prise en charge des effets secondaires des traitements anticancéreux : bases, bilan et perspectives

Lairedj,

Klausner,

Robijns

et al. 2024

Bulletin du Cancer

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État de l’art de la photobiomodulation dans la prise en charge des effets secondaires de la radiothérapie : indications et niveaux de preuve

Cited by 4 publications

References 65 publications

Orofacial Myofunctional Therapy with and without Photobiomodulation in the Rehabilitation of Radiation-Induced Trismus: Case Series

Orofacial Myofunctional Therapy with and without Photobiomodulation in the Rehabilitation of Radiation-Induced Trismus: Case Series

Effect of Photobiomodulation With Different Wavelengths on Radiodermatitis Treatment

Photobiomodulation dans la prévention et la prise en charge des effets secondaires des traitements anticancéreux : bases, bilan et perspectives

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