Etanercept restores vasocontractile sensitivity affected by mesenteric ischemia reperfusion

Öziş, Salih Erpulat; Akhayeva, Tamila; Güner, Şahika; Kılıçoğlu, Sibel Serin; Pampal, Arzu

doi:10.1016/j.jss.2018.01.005

Cited by 3 publications

(1 citation statement)

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“…It is the first therapeutic agent to specifically target TNFR2 signaling, by simulating TNFR2 shedding. While data is limited in the transplant context, etanercept use has been shown to be advantageous in limiting sequelae of IRI in various contexts, including kidney ( 82 ), heart ( 83 , 84 ), brain ( 85 , 86 ), and intestine ( 87 , 88 ).…”

Section: Tnfr2 Expression and Ischemia Reperfusion Injurymentioning

confidence: 99%

TFNR2 in Ischemia-Reperfusion Injury, Rejection, and Tolerance in Transplantation

Kouyoumdjian

Paraskevas

2022

Front. Immunol.

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Tumor necrosis factor receptor 2 (TNFR2) has been shown to play a crucial role in CD4+ T regulatory cells (CD4+Tregs) expansion and suppressive function. Increasing evidence has also demonstrated its role in a variety of immune regulatory cell subtypes such as CD8+ T regulatory cells (CD8+ Tregs), B regulatory cells (Bregs), and myeloid-derived suppressor cells (MDSCs). In solid organ transplantation, regulatory immune cells have been associated with decreased ischemia-reperfusion injury (IRI), improved graft survival, and improved overall outcomes. However, despite TNFR2 being studied in the context of autoimmune diseases, cancer, and hematopoietic stem cell transplantation, there remains paucity of data in the context of solid organ transplantation and islet cell transplantation. Interestingly, TNFR2 signaling has found a clinical application in islet transplantation which could guide its wider use. This article reviews the current literature on TNFR2 expression in immune modulatory cells as well as IRI, cell, and solid organ transplantation. Our results highlighted the positive impact of TNFR2 signaling especially in kidney and islet transplantation. However, further investigation of TNFR2 in all types of solid organ transplantation are required as well as dedicated studies on its therapeutic use during induction therapy or treatment of rejection.

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