Etanercept-induced asthma in a psoriatic patient resolving with transition to ustekinumab

Oral edible plant vaccine containing hypoallergen of American cockroach major allergen Per a 2 prevents roach-allergic asthma in a murine model

“…Though IL-6 and TNF-alpha Oral cockroach hypoallergen prevents roach-allergic asthma in mice have been known to play important roles in asthma [32], the paradoxical change of these proinflammatory cytokines did not seem to affect the inflammatory process in the airways according to the histopathology findings in the lung as shown on Fig 7 and airway hyperresponsiveness as shown at Fig 5. Human clinical studies using anti-TNF alpha inhibitors did not show clinical efficacy. There were even reports regarding etanercept and adalimumab -induced asthma for patients using these TNF-alpha inhibitors for other indications [33][34][35][36][37].…”

Development of pemphigus vegetans and exacerbation of pemphigus foliaceus after secukinumab loading in a patient with complicated generalized pustular psoriasis and pyoderma gangrenosum

“…Dupilumab, an interleukin (IL)‐4/IL‐13 receptor inhibitor, is associated with the emergence of Th17 type diseases 2 . Etanercept, a TNF‐α inhibitor, is associated with the induction of asthma, a Th2‐mediated disease 3 . Moreover, a substantial number of published reports have demonstrated the development of eczematous and atopic dermatitis‐like eruptions in patients with psoriasis treated with TNF‐α or IL‐17 inhibitors 4 .…”

“…2 Etanercept, a TNFα inhibitor, is associated with the induction of asthma, a Th2mediated disease. 3 Moreover, a substantial number of published reports have demonstrated the development of eczematous and atopic dermatitis-like eruptions in patients with psoriasis treated with TNFα or IL-17 inhibitors. 4 Furthermore, IL-17 promotes B cell isotype switching and germinal center formation, thereby associating with humoral immunity.…”