Et le mal démarrait…

Bouaziz, A.; Jouault, C.; Danquigny, A.-L.; Blanc-Pattin, V.; Rivoire, B.; Badet, F.; Vallet, Hélène

doi:10.1016/j.revmed.2016.05.011

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La Revue de Médecine Interne

2016

DOI: 10.1016/j.revmed.2016.05.011

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Et le mal démarrait…

A. Bouaziz¹,

C. Jouault²,

A.-L. Danquigny³

et al.

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Cited by 3 publications

(2 citation statements)

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“…This observation could rely on a 'semi-immune' status possibly acquired after repeat exposure to P. falciparum during infancy and resulting in a transient dampening of Ab response (likely due to the absence of exposure to recall stimulating antigens). Furthermore, Ab responses to malaria parasites are known to be versatile allowing occasional persistent parasitaemia [8].…”

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confidence: 99%

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Preventing transfusion‐transmitted malaria in France

et al. 2021

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confidence: 99%

“…The last reported TTM case in France occurred in 2015 [8]. It was caused by P. malariae, and the recipient recovered after anti-malarial treatment.…”

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confidence: 99%

Preventing transfusion‐transmitted malaria in France

et al. 2021

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Optimal malarial screening strategy in Australian blood donors: A cost‐effectiveness analysis

Cheng,

Hoad,

Bentley

et al. 2024

Vox Sanguinis

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Background and ObjectivesThe risk of transfusion‐transmitted malaria (TTM) infections is extremely low in Australia, and the cost‐effectiveness of the current screening strategy has not been assessed. This study aims to conduct a cost‐effectiveness analysis of different malaria screening strategies in blood donors as part of the risk‐based decision‐making framework.Materials and MethodsA decision tree model was developed to assess the cost‐effectiveness of five alternative malaria screening strategies from a healthcare sector perspective. Screening strategies combining total or partial removal of malaria testing with different deferral periods were considered. The probabilities of developing severe and uncomplicated TTM were based on a literature review of cases in non‐endemic areas since 2000. The health outcomes were quantified using disability‐adjusted life years. The costs of non‐returning donors due to deferral were also included. Deterministic and probabilistic sensitivity analyses were conducted to account for data uncertainty.ResultsThe residual risks for all strategies were so low that the costs, mortality and morbidity associated with TTM are almost negligible. The overall costs were predominantly influenced by the costs of non‐returning blood donors. As a result, removal of malaria testing and applying a 28‐day deferral for at‐risk donors were the least costly and most cost‐effective of all the options considered.ConclusionThe current screening strategy for malaria in blood donors in Australia is not an efficient use of healthcare resources. Partial or total removal of malaria testing would bring significant cost savings without significantly compromising blood safety.

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Transfusion-Transmitted Malaria and Mitigation Strategies in Nonendemic Regions

Niederhauser

Galel

2022

Transfus Med Hemother

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Background: Malaria is a mosquito-borne infectious disease caused by protozoan parasites of the genus Plasmodium. These parasites can be transmitted by blood transfusion especially through Red Cell Blood Concentrates collected from asymptomatic and parasitemic donors. As migration of populations from endemic areas to Europe and overseas recreational travel to endemic regions increase, there is growing risk of transfusion-transmitted malaria (TTM) in nonendemic regions of the world. The present work provides an overview of the mitigation strategies in nonendemic countries and their effectiveness and discusses possible approaches to evolve the strategies in order to maintain both a safe and adequate blood supply. Summary: The historical and current situation of malaria and TTM in Europe and on the North American continent are described. The infectivity of Plasmodium in blood components and the consequences of TTM are presented, along with the regulations and guidelines for TTM mitigation in Europe, USA, and Canada. The regulations/guidelines currently in place in Europe allow a certain amount of leeway for local policies. A questionnaire was used to survey European countries regarding their current strategies and recent TTM cases. From the questionnaire and published cases, approximately 20 cases of TTM were identified in the past 20 years in the USA and Europe. The vast majority of implicated donors have been former residents of malaria-endemic areas, particularly former residents of hyperendemic areas in Africa. The most recent TTM cases are discussed in detail to provide insight into the gaps in current strategies. The utility and uncertainties of pathogen reduction and serological and molecular testing methods are discussed. Key Messages: Overall, the risk of transfusion-associated malaria in nonendemic countries is considered to be low and very few TTM cases occurred in these regions in the last 20 years. The questionnaire-based strategy with questions about risk in relation to malaria exposure with or without selective testing based on questioning seems to be relatively effective, although rare and sometimes fatal transmissions still occur. An outstanding question is whether in the future molecular methods may further improve the safety of blood products and help constrain the loss of donors.

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Et le mal démarrait…

Cited by 3 publications

References 3 publications

Preventing transfusion‐transmitted malaria in France

Preventing transfusion‐transmitted malaria in France

Optimal malarial screening strategy in Australian blood donors: A cost‐effectiveness analysis

Transfusion-Transmitted Malaria and Mitigation Strategies in Nonendemic Regions

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