Estudos termoanalíticos da cimetidina e dos complexos com os íons Mn(II) Co(II) E Ni(II)

Abstract

ResumoA cimetidina (Cm) é um importante histamínico receptor de hidrogênio e pode coordenar íons metálicos no plasma sanguíneo. A estabilidade da cimetidina e dos seus complexos com os íons Mn(II), Co(II) e Ni(II) foi avaliada por estudos de termogravimetria (TG) e análise térmica diferencial (DTA AbstractCimetidine is an important hydrogen histamine receptor and can coordinate metal ions in blood plasma. The stability of cimetidine and its complexes with Mn(II), Co(II) and Ni(II) was evaluated by studies of thermogravimetry (TG) and differential thermal analysis (DTA). Cimetidine was thermally stable up to near 190 °C and above this temperature the thermal decomposition occurred in two stages. Complexes of [Mn(HCm) 2 ]Cl 2 , [Co(Cm) 2 ]Cl 2 and [Ni(Cm) 2 ]Cl 2 showed a similar behavior. The pyrolytic decomposition occurred in two stages at temperatures above 250 o C. A residue for each complex was detected at the end of the decomposition process. This probably corresponds to the respective metal oxide.