Estudo pareado da cardiopatia chagásica no Rio Grande do Sul, Brasil

Baruffa, Giovanni; Filho, Alcino Alcantara; Neto, José Ósimo de Aquino

doi:10.1590/s0074-02761985000400013

Cited by 6 publications

(3 citation statements)

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“…This variable was present in 43.5% (38/85) of the articles analyzed, which verified as significant or not the difference between male and female for chagasic seropositivity [76,[133][134][135][136]. However, despite men presenting more contact possibility with triatomines due to their work activities in the thumbtack's natural environment [13], and being majority among cases of trypanosomiasis [137], among the articles which consider "sex" as significant variable for CD spread (5.9%-5/85), all of them present a greater number of women infected [29,101,138,139].…”

Section: ➢ Sexmentioning

confidence: 69%

Predictor Variables in the Spread of Chagas Disease in Rural Areas

de Sousa Leite,

de Rezende Feres,

Scalize

2024

Pathogens

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Over a hundred years ago after the discovery of Chagas disease (CD) in Brazil, the World Health Organization estimates a number of 6 to 7 million people infected by Trypanosoma cruzi worldwide. Therefore, the goal of this work was to identify variables related to the spread of infection by T. cruzi in humans living in rural areas, seeking predictor variables. A systematic review of the literature has been conducted, with a search in the Scopus platform, using the search string “Chagas disease” and “rural”, resulting in 85 valid and analyzed scientific studies (1977 and 2022). Twenty-seven predictor variables have been acquired, and 19 of them have been grouped, such as: socioeconomic and educational, housing, environmental, sanitary, and cultural; and 8 variables related to T. cruzi seropositive individuals. The predictor variables yielded significant results (p-value < 0.05) in 59.5% of the cases (195/328), with a median of 66.7%. In other words, studies relating to 50% of the 27 variables showed significance equal to or greater than 66.7% of the time. The independent variables with the highest proportion of significant data (p-value < 0.05) were Education (87.6%), Intradomicile building (70%), Domestic animals (69.6%), and Triatomines (69.2%) in the households. Some variables reached 100%; however, few articles were found, indicating the need for further research, especially for Sanitation and Culture. It has been concluded that, in the several contexts found, the social vulnerability and lack of information led the individual to living in environments where inhabitability is inadequate, to perform limited work activity and develop habits and behaviors which impair them in an environmental insalubrity situation, favorable to the access of vectors and pathogens of anthropozoonoses such as CD.

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Section: ➢ Sexmentioning

confidence: 69%

Predictor Variables in the Spread of Chagas Disease in Rural Areas

de Sousa Leite,

de Rezende Feres,

Scalize

2024

Pathogens

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“…Chronic chagasic heart disease stands out as the object of many studies, classified as cross-sectional cohort, 45,46 prospective, 47,48 case-control, 49 and community-based intervention studies. 50 or experimental models during the acute phase, of focal inflammatory injuries, severe myocarditis, cardiac myocyte necrosis, and amastigote nests in the heart, as observed by Kosma 51 and Tafuri.…”

Section: The Progress Of Brazilian Science As Reflected By the Following Studies And Their Undisputable Contributionsmentioning

confidence: 99%

Revisiting the History of Chagas Disease: "Live to tell"

Cunha¹,

Cunha²

2021

International Journal of Cardiovascular Sciences

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In 1907, Carlos Chagas was designated to fight paludism in the Rio das Velhas region along the Central do Brasil railroad. During his field research, Chagas discovered a hematophagous insect (Panstrongylus megitus) carrying a new trypanosomatide, which he named Trypanosoma cruzi. On April 14th, 1909, he found the same parasite in the blood of a febrile child, submitting the announcement of his discoveries to the Brasil Médico scientific journal.Here, we discuss the early stages in the establishment of a new human morbid entity during the first decades after its discovery with a definite influence from its discoverer, Carlos Chagas, as well the first collaborators. Moreover, we cover the importance of the Center for the Study and Prophylaxis of Chagas Disease in Bambuí (MG), unraveling the most advanced developments in research within the disease's habitat and the widening perspectives for modern research that have emerged after the 1960s and continue to improve to this day.In this revisitation to the history of Chagas disease, we begin at Manguinhos (RJ ), making our way to Lassance (MG), where the discovery took place. Then, we travel back to Rio de Janeiro in the beginning of the twentieth century and Brazilian republic until the current day, revealing milestone publications that settled Chagas disease both as a source of pride for Brazilian medicine and as a challenge with important aspects that remain to be clarified. Any similarities to our country's politics and economy in the twentieth century are not mere coincidences. Carlos Chagas's research in the semi-arid region of Minas Gerais began in 1907 with the campaign against paludism in the Rio das Velhas river valley, aiming to save the lives of workers who worked in the expansion of the Central do Brasil railroad. The finding of a hematophagous insect (Panstrongylus megitus), strictly adapted to the domestic environment, with nocturnal habits and commonly known as the "barber bug" or "kissing bug" surprised Chagas, who intensified his research and found, in this insect, a new trypanosomatide named Trypanosoma cruzi. The further identification of T. cruzi in the blood of domestic animals and in the human blood directed Carlos Chagas to systematize a new human morbid entity.The choice of Carlos Chagas for the noble mission of battling malaria was due in great part to his strong scientific background on the theme with the completion, in Manguinhos, of his doctoral thesis named "Hematological studies of paludism," presented in 1903. This knowledge prompted him to systematize, in 1905, the household theory of infection by paludism. In 1907, Chagas participated in the group of scientists conducting the most brilliant research at the time, being designated to the anti-paludism campaign in Minas Gerais where, in Lassance, his path became the track for one of the most fascinating discoveries in the history of Medicine. Raquel Lewinsohn 1 and Berning 2 consider that Carlos Chagas, through his example, his life, and the aspects of his discovery, is unique in the hist...

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“…Macedo (Macedo, 1982) después de analizar 1.546 trazados electrocardiográficos de pacientes serorreactivos para la enfermedad de Chagas en Río Grande do Sul, Brasil, encontró un 24,5% de alteraciones. Años después, en un estudio similar realizado en el mismo estado, Baruffa (Baruffa, 1985) analizando 803 pacientes seropositivos halló una prevalencia de trastornos electrocardiográficos del 30,2%. Las alteraciones que caracterizaron la morbilidad cardíaca fueron las extrasístoles ventriculares polifocales, el bloqueo de rama derecha y el hemibloqueo anterior izquierdo aumentando progresivamente con la edad, especialmente entre los 40 y 59 años.…”

Section: Teoría Mixta O Constelacionalunclassified

Péptido natriurético Nt pro BNP en la fase crónica sin patología demostrable de la Enfermedad de Chagas, utilidad y aplicabilidad clínica

Oliva¹

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El Anteproyecto de este trabajo de investigación se desarrolló y presentó en el año 2010, antes que el último Consenso de Enfermedad de Chagas de la Sociedad Argentina de Cardiología (SAC 2011), incluyera a la determinación de BNP, en la metodología de estudio del paciente chagásico (Clase IIb Nivel C),. No hay publicación que evalúe la utilidad de esta determinación en la población de pacientes con enfermedad de Chagas en Argentina. Por lo tanto la determinación de BNP y los hallazgos relacionados con la evolución de los enfermos podrá tener impacto en las intervenciones asistenciales y en el sistema de salud. Un marcador elevado, antes del daño estructural clínicamente evidente, identificaría el grupo de pacientes al que iniciar tratamiento. <i>Hipótesis</i> Los valores de NT pro BNP, están elevados en un grupo de pacientes en la fase crónica sin patología demostrable de la Enfermedad de Chagas, identificarlos permitirá reconocer a un grupo de pacientes con daño miocárdico sin ninguna otra manifestación clínica aparente. <i>Objetivos</i> Conocer los valores de NT pro BNP en la fase crónica sin patología demostrable de la Enfermedad de Chagas y compararlos con los de una población normal, y así establecer su utilidad como marcador de afección cardíaca en aquella fase.

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Estudo pareado da cardiopatia chagásica no Rio Grande do Sul, Brasil

Cited by 6 publications

References 0 publications

Predictor Variables in the Spread of Chagas Disease in Rural Areas

Predictor Variables in the Spread of Chagas Disease in Rural Areas

Revisiting the History of Chagas Disease: "Live to tell"

Péptido natriurético Nt pro BNP en la fase crónica sin patología demostrable de la Enfermedad de Chagas, utilidad y aplicabilidad clínica

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