Estudo fitoquímico e avaliação da atividade anti-inflamatória de Aeschynomene fluminensis vell. (Fabaceae)

Ignoato, Marlene Capelin; Fabrão, Rodrigo Monteiro; Schuquel, Ivânia T.A.; Botelho, Marcos Felipe Pinatto; Santin, Silvana Maria de Oliveira; Arruda, Laura Lícia Milani de; Bersani-Amado, Ciomar Aparecida; Souza, Maria Conceição de

doi:10.1590/s0100-40422012001100028

Cited by 18 publications

(9 citation statements)

References 4 publications

(7 reference statements)

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“…The chemical structures of the compounds were elucidated using Nuclear Magnetic Resonance (NMR) data with 2D experiments Heteronuclear Single Quantum Coherence (HSQC) and Heteronuclear Multiple Bond Correlation (HMBC), Gas Chromatography/Mass Spectrometry (GC/MS) and comparison with the literature (copies of the original spectra can be obtained from the corresponding author). The compounds isolated from the leaves of M. tomentosa ( Figure 1 ) were identified as α-bisabolol ( Mt-1 ) [ 18 ], α-bisabolol oxide B ( Mt-2 ) [ 19 ], α-cadinol ( Mt-3 ) [ 19 ], β-sitosterol ( Mt-4 ) [ 20 , 21 ], n -pentacosane ( Mt-5 ) [ 19 ], n -tetracosane ( Mt-6 ) [ 19 ], quercetin ( Mt-7 ) [ 22 ], kaempferol ( Mt-8 ) [ 23 ], avicularin ( Mt-9 ) [ 22 , 24 ], juglanin ( Mt-10 ) [ 25 ] and guaijaverin ( Mt-11 ) [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Analysis and Antimicrobial Activity of Myrcia tomentosa (Aubl.) DC. Leaves

et al. 2017

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This work describes the isolation and structural elucidation of compounds from the leaves of Myrcia tomentosa (Aubl.) DC. (goiaba-brava) and evaluates the antimicrobial activity of the crude extract, fractions and isolated compounds against bacteria and fungi. Column chromatography was used to fractionate and purify the extract of the M. tomentosa leaves and the chemical structures of the compounds were determined using spectroscopic techniques. The antibacterial and antifungal activities were assessed using the broth microdilution method. The phytochemical investigation isolated 11 compounds: α-bisabolol, α-bisabolol oxide B, α-cadinol, β-sitosterol, n-pentacosane, n-tetracosane, quercetin, kaempferol, avicularin, juglanin and guaijaverin. The crude ethanolic extract and its fractions were tested against 15 bacteria and 9 yeasts. The crude extract inhibited the in vitro growth of yeasts at concentration of 4 to 32 μg/mL. The hexane, dichloromethane, ethyl acetate and aqueous fractions inhibited Candida sp. at concentrations of 4 to 256 μg/mL, whereas the Cryptococcus sp. isolates were inhibited only by the hexane and dichloromethane fractions in minimal inhibitory concentrations (MICs) at 16 to 64 μg/mL. The flavonoid quercetin-3-O-α-arabinofuranose (avicularin) was the most active compound, inhibiting Candida species in concentrations of 2 to 32 μg/mL. The MIC values suggest potential activity of this plant species against yeast.

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Section: Resultsmentioning

confidence: 99%

Phytochemical Analysis and Antimicrobial Activity of Myrcia tomentosa (Aubl.) DC. Leaves

et al. 2017

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“…is large shrub or small tree up to 9–12 m tall, belonging to the family Fabaceae. It is native to the tropical Africa and Madagascar, cultivated in Egypt, Java and South America [12], Plants of genus Aeschynomene are reported to exert hepatoprotective [13], antimicrobial [14], cytotoxic [15], antioxidant [16], anthelmintic [17] and anti-inflammatory activities [18]. Preliminary phytochemical studies among different Aeschynomene species revealed the presence of flavonoid glycosides [19], pterocarpans [20] and chalcones [21].…”

Section: Introductionmentioning

confidence: 99%

Metabolic profile and hepatoprotective effect of Aeschynomene elaphroxylon (Guill. & Perr.)

Hashem¹,

Salama²,

Mohammed³

et al. 2019

PLoS ONE

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Liver diseases are life-threatening and need urgent medical treatments. Conventional treatment is expensive and toxic, so the urge for nutraceutical hepatoprotective agents is crucial. This study is considered the first metabolic profile of Aeschynomene elaphroxylon (Guill. & Perr.) extracts of; flowers, leaves & bark adopting UPLC-Orbitrap HRMS analysis to determine their bioactive metabolites, and it was designed to investigate the potential hepatoprotective activity of A. elaphroxylon flowers and bark extracts against CCl4-induced hepatic fibrosis in rats. Forty-nine compounds of various classes were detected in the three extracts, with triterpenoid saponins as the major detected metabolite. Flowers and bark extracts presented similar chemical profile while leaves extract was quite different. The antioxidant activities of the flowers, leaves & bark extracts were measured by in vitro assays as Fe+3 reducing antioxidant power and Oxygen radical absorbance capacity. It revealed that flowers and bark extracts had relatively high antioxidant activity as compared to leaves extract. Based on the metabolic profile and in vitro antioxidant activity, flowers and bark ethanolic extracts were chosen for alleviation of hepatotoxicity induced by CCl4 in rats. The hepatoprotective activity was studied through measuring hepatotoxicity biomarkers in serum (ALT, AST, and Albumin). Liver tissues were examined histopathologically and their homogenates were used in determining the intracellular levels of oxidative stress biomarkers (MDA, GSH), inflammatory markers (TNF-α). Flowers and bark ethanolic extracts exerted a significant hepatoprotective effect through reduction in the activities of ALT, AST and Albumin, the tested extracts reduced oxidative stress by increasing GSH content and reducing the MDA level. Furthermore, the extracts decreased levels of pro-inflammatory TNF-α. Moreover, the present study revealed the potentiality of A. elaphroxylon in ameliorating the CCl4-induced hepatic fibrosis in rats. In this aspect, A. elaphroxylon can be used with other agents as a complementary drug.

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“…Aeschynomene fluminensis Vell., belonging to the Fabaceae family, is distributed throughout several states in Brazil, such as Paraná and Mato Grosso do Sul. Phytochemical studies of its leaves and branches, undertaken by Ignoato et al (2012), isolated flavonoids kaempferitrin, quercitin, avicularin, daidzein, iso-hemifloin, and steroids sitosterol and stigmasterol. The above-mentioned chemical compounds suggested a possible allelopathic potential and their use as bio-herbicides.…”

Section: Introductionmentioning

confidence: 99%

“…Current assay evaluates the allelopathic effect of A. fluminensis fractions by bio-assays involving initial growth in lettuce (Lactuca sativa L.), soybean (Glycine max Merril), morning glory (Ipomea grandifolia (Dammer) O'Donnel) and sourgrass (Digitaria insularis (L.) Fedde) seedlings and possible morpho-anatomic alterations. fluminensis leaves, previously obtained by Ignoato et al (2012), were kept under refrigeration and ceded for allelopathic evaluation.…”

Section: Introductionmentioning

confidence: 99%

Phytotoxic effects of Aeschynomene fluminensis Vell. on the initial growth of weeds and cultivated plants

Coelho

Oliveira

Souza

et al. 2021

RSD

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Allelopathy is analyzed as an alternative to herbicides due to the inhibitory or beneficent activities of its compounds with other organisms. Current paper discusses the effects of Aeschynomene fluminensis Vell. fractions on cultivated plant species, Lactuca sativa L. and Glycine max (L.) Merril, and on weeds, Ipomoea grandifolia (Dammer) O’Donnel and Digitaria insularis (L.) Fedde. Aqueous fractions at 0.80; 0.40; 0.20 and 0.10 mg mL-1 concentrations were employed for initial growth tests. Seeds were pre-germinated in distilled water and transferred to petri plates with separate fractions at different concentrations. Plates were maintained for 48 h in a germination chamber at 25°C for L. sativa and I. grandifolia and at 30°C for G.max and D. insularis. The length of hypocotyl (LH) and root (LR) was measured and LR and foliar length (LF) were taken for D. insularis seedlings. Parameters were employed to calculated inhibition percentage. Plants with morphological changes were fixed and analyzed anatomically. Results revealed LH and LR inhibition of lettuce seedlings in fractions with highest concentration rates. The same has been reported in the case of I. grandifolia. Butanolic, methanolic and chloroform fractions did not affect negatively soybean seedlings but they inhibited D. insularis seedlings´ LR. A. fluminensis fractions, especially at higher concentrations, inhibited seedlings´ growth and confirmed their phytotoxic capacity.

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Estudo fitoquímico e avaliação da atividade anti-inflamatória de Aeschynomene fluminensis vell. (Fabaceae)

Cited by 18 publications

References 4 publications

Phytochemical Analysis and Antimicrobial Activity of Myrcia tomentosa (Aubl.) DC. Leaves

Phytochemical Analysis and Antimicrobial Activity of Myrcia tomentosa (Aubl.) DC. Leaves

Metabolic profile and hepatoprotective effect of Aeschynomene elaphroxylon (Guill. & Perr.)

Phytotoxic effects of Aeschynomene fluminensis Vell. on the initial growth of weeds and cultivated plants

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