ESTUDO DO POTENCIAL MICROBIOLÓGICO DE NANOCRISTAIS HÍBRIDOS DE ZnO DOPADOS COM AgO

Sousa, Ellen Quirino de; Tavares, Lucas do Nascimento; Resende, Caio César Dias; Ferreira, Luzitano Brandão; Soares, Carlos José; Silva, Anielle Christine Almeida; Filho, Luís Ricardo Goulart; Filice, Letícia de Souza Castro

doi:10.22533/at.ed.4491904044

Cited by 1 publication

(3 citation statements)

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“…ZnO NPs, obtained through different chemical and green synthesis routes, have been widely applied in antimicrobial perspectives, showing promising performance against both Gram-positive and Gram-negative bacteria, although limitations regarding their spectrum of action have been observed. − In this context, the combination with other metallic nanoparticles, such as ZnO/AgNPs and Co–ZnO NPs, has been a strategy used to enhance the antimicrobial effect of the nanoproduct. , Although this study did not directly compare nanoproducts obtained from the incorporation of other metallic nanoparticles, recent studies present results similar to ours, reporting an improvement in antimicrobial activity with the incorporation of the nanoparticles. Furthermore, there is evidence that the incorporation of Au NPs exhibits better antimicrobial performance compared to the Ag/ZnO NP combination. , Doping of ZnO with metallic nanoparticles such as Ag has also been shown to be effective in controlling resistant bacteria. , Furthermore, they have shown efficacy in controlling parasites such as tegumentary Leishmaniasis. , …”

Section: Antimicrobial Activity Assaysmentioning

confidence: 99%

“…58,60 Furthermore, they have shown efficacy in controlling parasites such as tegumentary Leishmaniasis. 61,62 3.4. Au-Doped ZnO Nanocrystals Exhibit Higher Biocompatibility in Fruit Flies.…”

Section: Antimicrobial Activity Assaysmentioning

confidence: 99%

“… 58 , 60 Furthermore, they have shown efficacy in controlling parasites such as tegumentary Leishmaniasis. 61 , 62 …”

Section: Antimicrobial Activity Assaysmentioning

confidence: 99%

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Tuning Biocompatibility and Bactericidal Efficacy as a Function of Doping of Gold in ZnO Nanocrystals

Oliveira,

Silva,

Floresta

et al. 2024

ACS Omega

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Doping nanoparticles represents a strategy for modulating the energy levels and surface states of nanocrystals (NCs), thereby enhancing their efficiency and mitigating toxicity. Thus, we herein focus on the successful synthesis of pure and gold (Au)-doped zinc oxide (ZnO) nanocrystals (NCs), investigating their physical−chemical properties and evaluating their applicability and toxicity through in vitro and in vivo assessments. The optical, structural, and photocatalytic characteristics of these NCs were scrutinized by using optical absorption (OA), X-ray diffraction (XRD), and methylene blue degradation, respectively. The formation and doping of the NCs were corroborated by the XRD and OA results. While the introduction of Au as a dopant did induce changes in the phase and size of ZnO, a high concentration of Au ions in ZnO led to a reduction in their photocatalytic activity. This demonstrated a restricted antibacterial efficacy against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. Remarkably, Au-doped counterparts exhibited enhanced biocompatibility in comparison to ZnO, as evidenced in both in vitro (murine macrophage cells) and in vivo (Drosophila melanogaster) studies. Furthermore, confocal microscopy images showed a high luminescence of Au-doped ZnO NCs in vivo. Thus, this study underscores the potential of Au doping of ZnO NCs as a promising technique to enhance material properties and increase biocompatibility.

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