2018
DOI: 10.1590/0366-69132018643722379
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Estudo do efeito da modificação de superfície de Fe3O4 e CoFe2O4 para aplicação como carreador de fármaco

Abstract: Resumo Neste trabalho foram propostos obter e caracterizar o Fe3O4 e o CoFe2O4 associados ao tetraetilortossilicato (TEOS) e do 3-aminopropiltrimetoxissilano (APTS), visando avaliar o efeito da modificação de superfície das partículas magnéticas sobre as propriedades estrutural, morfológica e magnéticas para aplicação como carreador de fármaco. As amostras foram caracterizadas por difração de raios X, espectroscopia no infravermelho com transformada de Fourier, análise textural, microscopia eletrônica de varre… Show more

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Cited by 3 publications
(2 citation statements)
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“…The methodology proposed by Araújo [ 27 ] was used to obtain the biomaterials. The procedure is summarized as follows: (i) 2.5 g of CoFe 2 O 4 MNPs and 100 mL of ethanol, under ultrasonic agitation for 30 min, were coated with TEOS (tetraethylorthosilicate) and APTS (3-aminopropyltrimethoxysilane), resulting in a core–shell-type structure with reactive -OH and NH 2 groups; (ii) after obtaining the CoFe 2 O 4 @SiO 2 hybrid, it was physically mixed with hydroxyapatite (HAp), resulting in a HAp:CoFe 2 O 4 @SiO 2 composite.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The methodology proposed by Araújo [ 27 ] was used to obtain the biomaterials. The procedure is summarized as follows: (i) 2.5 g of CoFe 2 O 4 MNPs and 100 mL of ethanol, under ultrasonic agitation for 30 min, were coated with TEOS (tetraethylorthosilicate) and APTS (3-aminopropyltrimethoxysilane), resulting in a core–shell-type structure with reactive -OH and NH 2 groups; (ii) after obtaining the CoFe 2 O 4 @SiO 2 hybrid, it was physically mixed with hydroxyapatite (HAp), resulting in a HAp:CoFe 2 O 4 @SiO 2 composite.…”
Section: Methodsmentioning
confidence: 99%
“…Among the most common, magnetite (FeFe 2 O 4 ) and hematite (Fe 2 O 3 ) stand out for presenting nontoxic characteristics and magnetizing force suitable for biological applications [ 26 ]. In the magnetite category, which presents a spinel-like crystalline structure, cobalt ferrite (CoFe2O4) has been widely researched due to its low-toxicity characteristics, excellent water solubility, physiological pH stability, and magnetic behavior suitable for use in biosensors [ 27 ]. CoFe 2 O 4 has been used in several biomedical applications as a catalyst, in hyperthermia treatment, magnetic resonance imaging, and in biosensors, among others.…”
Section: Introductionmentioning
confidence: 99%