Orofacial Manifestations and their Correlation to the Clinical and Immunological Classification in HIV-Infected Children in the city of João Pessoa, PB, Brazil Objective: To evaluate the prevalence of orofacial manifestations and their correlation to the immunological classification in HIVinfected pediatric patients. Method: Twenty-one HIV-positive children (12 boys and 9 girls; age range = 2 to 12 years; mean age = 6.4 ±2.8 years) treated at the Hospital Complex Clementino Fraga in the city of João Pessoa, PB, Brazil, were enrolled in this study. The children were clinically examined for the presence of oral manifestations, considering the lesions existing at the moment of clinical examination. Medical data, including the form of HIV contamination, CD4 count, anti-retroviral therapy in use, and clinical classification of the child's disease, were obtained from the hospital files and recorded in specific forms. Results: Among the examined children, 95.2% (n=20) were vertically infected and all children were under anti-retroviral therapy. The following manifestations were found in 15 patients (71.4%): cervicofacial lymphadenopathy (28.5%), parotid gland hypertrophy (23.8%), pseudomembranous candidiasis (19%), angular cheilitis (19%), and linear gingival erythema (4.7%). As regards the immunodepression level, 38% of the children were classified as immunocompetent, 38% presented moderate immunodepression and 23% had severe immunodepression. As to the oral lesions, the pseudomembranous candidiasis was prevalent (60%) among the patients with severe immunodepression. There was a statistically significant correlation between the presence of oral manifestations and the immunodepression level. Conclusion: The orofacial manifestations were frequent among the children in this study and their presence was associated to the level of immunodepression.