Estudo das alterações ecocardiográficas nos primeiros seis meses após o transplante renal

Cardiovascular event rates are high in patients with chronic kidney disease (CKD), increasing with deteriorating kidney function, highest in CKD patients on dialysis, and improve with kidney transplantation (KTx). The cardiovascular events in CKD patients such as myocardial infarction and heart failure are related to abnormalities of vascular and cardiac structure and function. Many studies have investigated the structural and functional abnormalities of the heart and blood vessels in CKD, and the changes that occur with KTx, but the evidence is often sparse and occasionally contradictory. We have reviewed the available evidence and identified areas where more research is required to improve the understanding and mechanisms of these changes. There is enough evidence demonstrating improvement of left ventricular hypertrophy, except in children, and sufficient evidence of improvement of left ventricular function, with KTx. There is reasonable evidence of improvement in vascular function and stiffness. However, the evidence for improvement of vascular structure and atherosclerosis is insufficient. Further studies are necessary to establish the changes in vascular structure, and to understand the mechanisms of vascular and cardiac changes, following KTx.

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“…[ 11 14 15 27 ] Similarly, diastolic function had also been shown to improve following transplantation in four studies. [ 24 26 27 29 ]…”

Section: Methodsmentioning

confidence: 99%

Cardiac and vascular changes with kidney transplantation

Ali¹,

MacPhee²,

Kaski³

et al. 2016

Indian J Nephrol

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“…One study, assessing 50 individuals before and 3 months after renal transplantation, demonstrated significant improvement of the ejection fraction and reduction of the chamber diameters [12]. This increase is reported in other studies as well [10, 13, 14]. …”

Section: Discussionmentioning

confidence: 61%

“…It is reported that successful renal transplantation has positive effects on ventricular hypertrophy and could regress LVH and improve LVEF during the first year after transplantation [6-10]. …”

Section: Introductionmentioning

confidence: 99%

Brief report: left ventricle hypertrophy, dilatation and ejection fraction changes before and after kidney transplantation

et al. 2013

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BackgroundPatients with end stage renal disease (ESRD) are at risk of complications in different organs including cardiovascular system. Renal transplantation is the best choice in these patients which diminishes these complications. It is observed that after renal transplantation, cardiac parameters have appropriate improvement. Current study evaluates echocardiographic findings in renal transplant recipients before and after kidney transplantation.MethodsIn an analytic cross sectional study, 30 patients (50% male, mean age of 45.57 ± 13.32 years) with ESRD who underwent renal transplantation were studied. All patients had echocardiographic studies after the last dialysis before and 6 months after transplantation. Echocardiographic study was done by Color Doppler two dimension methods and left ventricle ejection fraction was measured by Simpson method. All echocardiograms before and after transplantation were interpreted by the same cardiologist.ResultsMean left ventricle ejection fraction before and after renal transplantation was 53.83±10.14% and 57.33±4.49%, respectively (P = 0.09). Left ventricle hypertrophy, mitral regurgitation and tricuspid regurgitation existed in 46.7%, 76.7% and 33.3% respectively, which was improved in 30%, 50% and 33.3% after renal transplantation.ConclusionAccording to the results of current study it is suggested that renal transplantation could improve left ventricle parameters in patients with end stage renal disease.

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“…Left ventricular ejection fraction has been shown to be a better predictor [ 10 ] of posttransplant outcomes. It is often felt that the uremic milieu, volume overload, and chronic anemia contribute to the underlying dysfunction and that cardiac function may improve with transplantation [ 12 ]. Studies by Sharma et al [ 13 ] have suggested that a reliable assessment of preoperative cardiac disease would utilize dobutamine stress echocardiogram.…”

Section: Prevention and Treatment Of Cardiovascular Disease In Renal mentioning

confidence: 99%

The Prevention and Treatment of Coronary Artery Disease in Kidney Transplant Recipients

Adey

2014

Kidney Transplantation

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Estudo das alterações ecocardiográficas nos primeiros seis meses após o transplante renal

Abstract: Background: Cardiac disorders are very common in individuals with chronic kidney disease and are associated with morbimortality.

Cited by 12 publications

References 34 publications

Cardiac and vascular changes with kidney transplantation

Cardiac and vascular changes with kidney transplantation

Brief report: left ventricle hypertrophy, dilatation and ejection fraction changes before and after kidney transplantation

The Prevention and Treatment of Coronary Artery Disease in Kidney Transplant Recipients

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