Estudio transversal clínico y epidemiológico de la enfermedad de Chagas en una área rural del Nordeste Argentino

Bar, María Esther; Pozzer, Domingo; Alvarez, Benedicta Mabel; Vallejos, Julio Andrés; Storino, Rubén

doi:10.1590/s0037-86821998000200006

Cited by 3 publications

(3 citation statements)

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“…However, left bundle branch block has been reported with high frequency in patients with Chagas disease, especially in asymptomatic cases [21][22] ; likewise, in patients with chagasic heart disease, the frequency of right bundle branch block is similar to that previously ACKNOWLEDGMENTS reported 23 . On the other hand, in Venezuela no difference between seropositive and seronegative patients has been reported in terms of the prevalence of chronic heart disease in adults from rural communities, suggesting the existence of a rural endemic chronic heart disease in this country 24 .…”

Section: Discussionsupporting

confidence: 72%

Prevalence of Trypanosoma cruzi antibodies and inflammatory markers in uncompensated heart failure

Bravo-Tobar

Parra²,

Pérez

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Introduction: Heart failure (HF) represents the final stage of chronic chagasic cardiomyopathy (CChC). The diagnosis of CChC is based on the demonstration of anti-Trypanosoma cruzi antibodies (aTcAg) and clinical and epidemiological data. In Venezuela, there are no data about the prevalence of chagasic HF. The aim of this study was to determine the epidemiological, clinical, and inflammatory risk factors associated with seronegative or seropositive HF patients. Methods: We performed a cross-sectional study in the Venezuelan central-west states among a healthy rural population and in patients admitted to the emergency room with uncompensated HF. Results: The seroprevalence rates of Trypanosoma cruzi antibodies were 11.2% and 40.1% in the healthy population and in HF patients, respectively. Seropositivity in healthy individuals was associated with age, knowledge on triatomine vectors, and having seen wild reservoirs in the house; in HF patients, with contact with the vector and previous clinical diagnosis of Chagas' disease; and in both groups taken together, with age, knowledge on triatomines, and HF. Seropositive patients had prolonged QRS, decreased ejection fraction, and high serum magnesium, all significant as compared with HF seronegative cases. Left atrium enlargement and ventricular hypertrophy were most frequently observed in HF seronegative patients. CRP, IL6, ILβ1, IL2, and FNTα were elevated in 94.5%, 48%, 17.8%, 13.7%, and 6.9% of HF patients, respectively, but only IL2 levels were associated with chagasic HF. Conclusions: There is a high prevalence of aTcAg in HF patients from the central-west region of Venezuela, and their epidemiological, clinical, and inflammatory features are discreetly different as compared with those of seronegative cases.

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Section: Discussionsupporting

confidence: 72%

Prevalence of Trypanosoma cruzi antibodies and inflammatory markers in uncompensated heart failure

Bravo-Tobar

Parra²,

Pérez

et al. 2011

Rev. Soc. Bras. Med. Trop.

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“…[72][73][74] Importantly, these alterations are common in chronic Chagas' heart disease. 56,57,63,75 The first-degree AV conduction disturbance and T wave abnormalities were also observed in one of the T. cruzi-infected monkeys (monkey 103). Furthermore, the first-degree AV block suggests damage to the atrioventricular node or to the autonomic nervous tissue supplying these regions that occurs mainly during the early stages of chronic Chagas' disease.…”

Section: Discussionmentioning

confidence: 97%

“…Interestingly, we have shown that rhesus monkeys chronically infected with the Colombian strain developed electrocardiographic alterations similar to those observed in chronic chagasic patients. [54][55][56][57][58][59][60][61][62][63][64] Electrocardiographic abnormalities, suggesting the presence of acute T. cruzi-elicited myocarditis, have been described in Cebus apella and Saimiri sciureus. 44,[65][66][67][68][69][70] In fact, our animals presented several ECG abnormalities attributed to the presence of the parasite in the cardiac tissue from the fourth week of infection up to the 12th week of the acute phase.…”

Section: Discussionmentioning

confidence: 99%

Chronic Chagas’ Disease in Rhesus Monkeys (Macaca Mulatta): Evaluation of Parasitemia, Serology, Electrocardiography, Echocardiography, and Radiology

Carvalho¹,

Andrade²,

Xavier³

et al. 2003

The American Journal of Tropical Medicine and Hygiene

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Severe chronic damage to the heart and gastrointestinal tract in patients with Chagas' disease are often observed 10-20 years after the acute phase. The course of long-lasting infection with the Colombian strain of Trypanosoma cruzi was studied in seven rhesus monkeys infected for 15-19 years. Subpatent parasitemia was detected in all studied animals, using hemoculture (two of seven), artificial xenodiagnosis (three of seven), and a polymerase chain reaction PCR (six of six). High titers of specific IgG antibody to T. cruzi persisted throughout the chronic phase of infection. Abnormal electrocardiographic (three of six) and echocardiographic (one of six) patterns detected in the T. cruzi-infected monkeys were possibly related to parasite-triggered myocardial damage. The results suggest that rhesus monkeys experimentally infected with T. cruzi, besides reproducing the acute phase of Chagas' disease, also develop chronic chagasic cardiomyopathy.

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Prevalencia de tripanomiasis americana en mujeres gestantes de un área de salud: Valencia, 2005-2007

Lucas

Barba

2009

Rev. Esp. Salud Publica

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RESUMENFundamento: La enfermedad de Chagas es una patología emergente en nuestro medio debido principalmente al incremento de las migraciones. La prevalencia y el difícil manejo terapéutico hacen del Chagas un problema de salud pública creciente. Pretendemos analizar la prevalencia y perfil epidemiológico de mujeres gestantes latinoamericanas atendidas en el área de influencia del Hospital Clínico de Valencia (HCUV) y estimar el riego de transmisión vertical.Métodos: Se estudió a 383 mujeres gestantes asistidas en el HCUV entre febrero de 2005 y julio de 2007. Utilizamos para el cribado la técnica de inmunoprecipitación ID-PaGIA-DiaMed, confirmada mediante Inmunofluorescencia Indirecta (IFI) -Inmunoflour Chagas-Inverness Medical. En hijos de mujeres positivas: Microhematocrito, PCR y detección de anticuerpos IgM por IFI, al nacer, e IgG, a los 6 y 12 meses.Resultados: El 9,7% de las mujeres presentaban anticuerpos específicos del parásito. De ellas el 54,1% eran bolivianas, el 13,5% argentinas y 8,1 % colombianas. 81,1% vivieron en zonas rurales y casas de adobe, el 89,2% tenía antecedentes familiares y el 100% conocían la enfermedad y el vector. La seroconversión en un niño de 8 meses supuso una transmisión vertical del 2,7% y una incidencia en mujeres procedentes de zona endémica del 0,3%.Conclusiones: La prevalencia de enfermedad de Chagas en mujeres gestantes latinoamericanas es elevada y supone un riesgo de transmisión vertical importante que obliga a detectar anticuerpos frente al parásito en los exámenes de salud de este colectivo. En el cribado son factores de riesgo los antecedentes familiares de tripanosomiasis y la residencia previa en hábitat rural.

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Estudio transversal clínico y epidemiológico de la enfermedad de Chagas en una área rural del Nordeste Argentino

Abstract: Resumen Esta investigación tiene por objeto analizar las características epidemiológicas, clínicas, electrocardiográficas y radiológicas de una población de seropositivos y seronegativos al

Cited by 3 publications

References 5 publications

Prevalence of Trypanosoma cruzi antibodies and inflammatory markers in uncompensated heart failure

Prevalence of Trypanosoma cruzi antibodies and inflammatory markers in uncompensated heart failure

Chronic Chagas’ Disease in Rhesus Monkeys (Macaca Mulatta): Evaluation of Parasitemia, Serology, Electrocardiography, Echocardiography, and Radiology

Prevalencia de tripanomiasis americana en mujeres gestantes de un área de salud: Valencia, 2005-2007

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