Estudio Quimico De Especies De La Familia Euphorbiaceae en Chile

Bittner, M.; Alarcón, Julio; Aqueveque, Pedro; Becerra, José; Hernandez, Valentina; Hoeneisen, M.; Silva, M.

doi:10.4067/s0366-16442001000400006

Cited by 9 publications

(8 citation statements)

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“…Block et al (2005), Jassbi (2006) and Aliabadi et al (2009) attribute this antitumoural activity to nonpolar constituents such as terpenoids that are very abundant in the chemical constitution of the Euphorbiaceae family. Terpenes that are present in latex as well as other parts of several species of the genus Synadenium are described to present cytotoxic activity (Bagavathi et al, 1988;Olivier et al, 1992;Bittner et al, 2001;Costa et al, 2012;Hassan et al, 2012). The 1 H and 13 C NMR spectra of hexane, chloroform and ethyl acetate fractions of the latex showed characteristic signals due to terpenes.…”

Section: Discussionmentioning

confidence: 95%

“…Previous phytocemical investigations of this family, mainly in the search for new biologically active compounds, have revealed the presence of flavonoids, saponins, terpenes, esters, alkaloids, cyanogenic glycosides, tannins, lectins and glycoproteins (Premaratna et al, 1981;Bittner et al, 2001;Souza et al, 2005;Rajesh et al, 2006;Rogério et al, 2007).…”

Section: Introductionmentioning

confidence: 98%

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Antitumoural effect of Synadenium grantii Hook f. (Euphorbiaceae) latex

Oliveira¹,

Munhoz²,

Lemes³

et al. 2013

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 98%

Antitumoural effect of Synadenium grantii Hook f. (Euphorbiaceae) latex

Oliveira¹,

Munhoz²,

Lemes³

et al. 2013

Journal of Ethnopharmacology

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“…This family is predominantly found in Africa and the Americas, mainly in tropical or arid habitats (Bittner et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Anti-ulcer activity of Synadenium grantii latex

Costa¹,

David²,

Pinto³

et al. 2012

Rev. bras. farmacogn.

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Synadenium grantii Hook f., Euphorbiaceae, is popularly known as leitosinha or janaúba. The diluted latex (18 drops/L of water) is commonly used in the south of Brazil to treat gastric disturbances. This study evaluated phytochemical screening and toxicity using Artemia salina Leach of crude bark extract and also latex. The toxicity and the anti-ulcer activity of S. grantii latex were also tested in rats. Phytochemical results showed presence of tannins, terpenes, unsaponificable substances, coumarins and anthraquinones in the crude bark extract and terpenes in the latex. Gas chromatography-mass spectrometry (GC-MS) analysis demonstrated the presence of diterpene tigliane esters in the latex, identified as 12-deoxyphorbol-13-(2-metilpropionate) and phorbol 12,13,20-triacetate. The toxicity results using A. salina presented CL50 26.58μg/mL and CL50 778.66μg/mL, for the latex and the crude bark extract respectively. The toxicological hepatic parameters of the diluted latex were not different to the control group (p<0.05). The eosinophils cells showed an increase in both the diluted and pure latex groups. The pure latex showed gastric protection of 90% (p<0.05) and the diluted latex showed 6% compared to the negative control. Therefore, our data indicate that S. grantii latex, under research conditions presented gastric protection. Pure latex showed more toxicity than the diluted latex.

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“…Apparently, to date, the only known natural source of the dextrorotatory pallidine is Croton chilensis [32], the only Croton sp. growing in Chile [33].…”

Section: Resultsmentioning

confidence: 99%

Preliminary Phytochemical Study of the Ecuadorian Plant Croton Elegans Kunth (Euphorbiaceae)

Herrera

Pérez

Morocho

et al. 2018

J. Chil. Chem. Soc.

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The species Croton elegans Kunth, belonging to the family Euphorbiaceae and known with the common name "mosquera", is a native medicinal plant of Ecuador. Due to its medical applications, we are interested in secondary metabolite composition. After extraction with hexane and preparation of the alkaloid extract, preparative chromatographic fractionation in both normal and direct phase was performed. 1 H NMR, 13 C NMR, HSQC and HMBC experiments, together with polarimetric measurements, were conducted in order to characterize the purified compunds. Two triterpene metabolites (friedelin and cycloeucalenol) and two morphinan alkaloids ((+)-pallidine and (+)-O-methylpallidine) were obtained in a pure form. This work represents the first report on the phytochemistry of C. elegans and probably the second publication on the natural (+)-pallidine alkaloid.

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Estudio Quimico De Especies De La Familia Euphorbiaceae en Chile

Cited by 9 publications

References 0 publications

Antitumoural effect of Synadenium grantii Hook f. (Euphorbiaceae) latex

Antitumoural effect of Synadenium grantii Hook f. (Euphorbiaceae) latex

Anti-ulcer activity of Synadenium grantii latex

Preliminary Phytochemical Study of the Ecuadorian Plant Croton Elegans Kunth (Euphorbiaceae)

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