Estudio piloto sin grupo control del tratamiento con magnesio y vitamina B6 del síndrome de Gilles de la Tourette en niños

García-López, Raquel Presa; Romero-González, Julio; Perea-Milla, Emilio; Ruiz-García, César; Rivas‐Ruiz, Francisco; Béjar, Mariano de las Mulas

doi:10.1157/13129113

Cited by 12 publications

(4 citation statements)

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“…A few data from the literature have investigated the efficacy of nutritional supplements in the treatment of tic disorders and other neuropsychiatric conditions in pediatric cohorts. Garcia-Lopez et al [16,25] investigated the effectiveness and safety of magnesium and vitamin B6 with respect to placebo treatment and demonstrated that a collateral treatment with magnesium and vitamin B6 could improve control of the illness and help reduce side effects. The treatment assayed was safe and effective in alleviating the harmful effects of TS in children, by a reduction of total tics score measured by YGTSS [25].…”

Section: Discussionmentioning

confidence: 99%

“…Garcia-Lopez et al [16,25] investigated the effectiveness and safety of magnesium and vitamin B6 with respect to placebo treatment and demonstrated that a collateral treatment with magnesium and vitamin B6 could improve control of the illness and help reduce side effects. The treatment assayed was safe and effective in alleviating the harmful effects of TS in children, by a reduction of total tics score measured by YGTSS [25]. Mantel et al [36] also described benefits in the reduction of tics after the incorporation of nutritional and dietary changes [36].…”

Section: Discussionmentioning

confidence: 99%

“…Participants were randomly assigned into two groups using a simple randomization plan based on a random number list in a ratio of 1:1, the "N-group" (n = 17), which didn't receive the nutritional supplement for two months, and the "THE-group" (n = 17), which received the nutritional supplements L-Theanine (200 mg/day) and vitamin B6 (2.8 mg/day) for two months. Based on the previous clinical trials on neurodevelopmental disorders, dose selection for L-Theanine and vitamin B6 was considered safe and well tolerated to our patients [19,[21][22][23][24][25][26][27].…”

Section: Methodsmentioning

confidence: 99%

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Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study

et al. 2022

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Background: Tourette syndrome (TS) is a neurodevelopmental disorder characterized by tics and co-occurring disorders. It has been suggested that anxiety occurs in 2–45% patients affected by Tourette syndrome. Despite dietary and nutritional factors have been found to affect a range of neurological conditions, no more studies have investigated the relationship between nutritional supplements and tics. Objective: To evaluate the effectiveness of supplementation of both L-Theanine and Vitamin B6 in reducing tics and co-occurring disorders in a sample of youth with chronic tic disorder (CTD) or Tourette syndrome with anxiety symptoms. Design: A open-label trial. Patients affected by Tourette syndrome were randomized to receive nutritional supplements based on L-Theanine and vitamin B6, or psychoeducation (PE). Participants: 34 children (30 boys and 4 girls) aged between 4 and 17 years affected by Tourette syndrome or chronic tic disorder, associated with anxiety symptoms. Results: Patients in both groups showed a reduction in the severity of tic and anxiety symptoms. Supplementation with L-Theanine and vitamin B6 was significantly more effective than psychoeducation in reducing tics and co-occurring disorders, as measured by neuropsychological findings. Conclusions: Supplementation of both L-Theanine and Vitamin B6 may help in the treatment of tic disorders associated with anxious symptoms. Between-group differences in clinician-rated severity did reach statistical significance only for tics. Despite this finding, further placebo-controlled trials are needed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study

et al. 2022

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“…One open-label study did show improvement in tics in patients given L-Theanine and Vitamin B6 as compared with a control condition of psychoeducation [76]. Additionally, an open-label study of magnesium and vitamin B6 showed an improvement in children with TS suffering from clinical exacerbations [77]. However, further placebo-controlled studies are necessary.…”

Section: Diet and Supplementsmentioning

confidence: 99%

Why tic severity changes from then to now and from here to there

Iverson¹,

Black²

2022

Preprint

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Much of the research regarding Tourette’s syndrome (TS) has focused on why certain individuals develop tics while others do not. However, a separate line of research focuses on the momentary influences that cause tics to increase or decrease in patients with a who are already known to have TS or another chronic tic disorder (CTD). Environmental and internal variables such as fatigue, anxiety, and certain types of thoughts all have been shown to worsen tic severity and may even overcome positive effects of treatment. Other influences such as stress, distraction, and being observed have had mixed effects in the various studies that have examined them. Still other variables such as social media exposure and dietary habits have had only minimal research attention, and would benefit from additional study. In understanding the impact of these environmental and internal influences, there is opportunity to improve behavioral treatments for TS/CTD and improve the lives of those living with these conditions. This review will examine the current literature on how these moment-to-moment influences impact tic expression in those with TS/CTD.

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Behavioral and Psychosocial Treatments of Dementia in the Caribbean: Cuba, Dominican Republic, and Puerto Rico

Jiménez‐Velázquez

Rodriguez

Acosta

et al. 2020

Caring for Latinxs With Dementia in a Globalized World

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Estudio piloto sin grupo control del tratamiento con magnesio y vitamina B6 del síndrome de Gilles de la Tourette en niños

Cited by 12 publications

References 9 publications

Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study

Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study

Why tic severity changes from then to now and from here to there

Behavioral and Psychosocial Treatments of Dementia in the Caribbean: Cuba, Dominican Republic, and Puerto Rico

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