Estudio experimental sobre la utilidad del aceite de copolímero de silicona-fluorsilicona (SiFO) en la cirugía vitreorretiniana

Fidalgo, C Baílez; Jimeno, José Carlos Pastor; Álvarez, Martina; Díaz, M C Méndez; Aparicio, F Martín; Franch, Enrique Rodríguez de la Rúa; Ruiz-Colmenares, R M Sanabria; Salinero, M A De La Fuente

doi:10.4321/s0365-66912004000500004

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“…A copolymer of PDMS and FsiO was evaluated in order to avoid the anatomical damages caused by PFCLs with the aim of decreasing the specific gravity (density, 1.16 g/cm 3 ) of the tamponade [60]. …”

Section: Internal Tamponade Agentsmentioning

confidence: 99%

Heavy Silicone Oil and Intraocular Inflammation

Morescalchi

Costagliola

Duse

et al. 2014

BioMed Research International

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In the past two decades, many advances have been made in vitrectomy instrumentation, surgical techniques, and the use of different tamponade agents. These agents serve close retinal breaks, confine eventual retinal redetachment, and prevent proliferative vitreoretinopathy (PVR). Long-acting gases and silicone oil are effective internal tamponade agents; however, because their specific gravity is lower than that of the vitreous fluid, they may provide adequate support for the superior retina but lack efficacy for the inferior retina, especially when the fill is subtotal. Thus, a specific role may exist for an internal tamponade agent with a higher specific gravity, such as heavy silicone oils (HSOs), Densiron 68, Oxane HD, HWS 45-300, HWS 46-3000, and HeavySil. Some clinical evidence seems to presume that heavy tamponades are more prone to intraocular inflammation than standard silicone if they remain in the eye for several months. In this review, we discuss the fundamental clinical and biochemical/molecular mechanisms involved in the inflammatory response after the use of heavy tamponade: toxicity due to impurities or instability of the agent, direct toxicity and immunogenicity, oil emulsification, and mechanical injury due to gravity. The physical and chemical properties of various HSOs and their efficacy and safety profiles are also described.

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Section: Internal Tamponade Agentsmentioning

confidence: 99%