Abstract:Cells respond to environmental stimuli by fine tuned regulation of gene expression. In this thesis we investigate the dose dependent modulation of the genetic response upon nutrient and stress signals in yeast. A destabilized version of firefly luciferase was used in living yeast cells as a real-time reporter for gene expression. This highly sensitive and non-invasive system can be simultaneously used upon many different experimental conditions in small culture aliquots. This allows the dose-response behaviour… Show more
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