Estudio de factores físico-químicos en pacientes con litiasis renal

Martín, Miguel Arrabal; Rodríguez, Antonio Fernández; Polo, Miguel Ángel Arrabal; García, Maria José Ruíz; Gómez, Armando Zuluaga

doi:10.4321/s0004-06142006000600004

Cited by 10 publications

(15 citation statements)

References 34 publications

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“…A fasting urine test to assess the levels of calcium, creatinine, oxalate and citrate is also recommendable. 5,[7][8][9][10][11][12][13][14][15][16][17][18][19] The analysis should be extended in order to determine the levels of…”

Section: Metabolic Diagnosismentioning

confidence: 99%

“…5,9,24 Although the term idiopathic hypercalciuria has been used for years to refer to increased urinary calcium levels, it is more accurate to talk about distinct types of hypercalciuria, on the basis that the calcium transport defect may be localized in the gastrointestinal tract, bones or kidneys.…”

Section: Prevention and Pharmacological Treatmentmentioning

confidence: 99%

“…5,[19][20][21][22][23][24][25] • Absorptive hypercalciuria: Three types of hypercalciuria have been defined and are characterized by having a calcium/creatinine ratio in urine of less than 0.11 during fasting, and less than 0.22 when there is an overload of calcium in the diet.…”

Section: Prevention and Pharmacological Treatmentmentioning

confidence: 99%

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Calcium renal lithiasis: metabolic diagnosis and medical treatment

2013

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Calcium renal lithiasis is a frequent condition that affects the worldwide population and has a high recurrence rate. Different metabolic changes may trigger the onset of calcium stone disorders, such as hypercalciuria, hyperoxaluria, hyperuricosuria, hypocitraturia and others. There are also other very prevalent disorders that are associated with calcium calculi, such as arterial hypertension, obesity and loss of bone mineral density. A correct diagnosis needs to be obtained through examining the serum and urinary parameters of mineral metabolism in order to carry out adequate prevention and treatment of this condition. Once the metabolic diagnosis is known, it is possible to establish dietary and pharmacological treatment that may enable monitoring of the disease and prevent recurrence of stone formation. Some advances in treating this pathological condition have been made, and these include use of sodium alendronate in patients with calcium renal lithiasis and osteopenia/osteoporosis, or use of a combination of a thiazide with a bisphosphonate. In summary, calcium renal lithiasis often requires multidrug treatment with strict control and follow-up of patients. RESUMOLitíase renal cálcica é uma doença comum que afeta a população no mundo todo e tem alta taxa de recorrência. Diferentes alterações metabólicas podem desencadear o aparecimento de distúrbios de pedras de cálcio, como hipercalciúria, hiperoxalúria, hiperuricosúria, hipocitratúria e outros. Existem também doenças altamente prevalentes associadas à doença de cálculo de cálcio, como hipertensão, obesidade e perda de densidade óssea mineral. Para realizar prevenção e tratamento adequados, é necessário diagnóstico correto, examinando o metabolismo mineral sérico e urinário. Depois de conhecer o diagnóstico metabólico, é possível estabelecer um tratamento dietético e farmacológico que permita controlar a doença e prevenir a recorrência de cálculos biliares. Há alguns avanços no tratamento dessa doença e incluem o uso de alendronato de sódio em pacientes com nefrolitíase de cálcio e osteopenia/osteoporose, ou a combinação de um tiazídico com um bifosfonato. Em resumo, litíase renal cálcica exige, muitas vezes, um tratamento multidroga com rigorosos controle e acompanhamento de pacientes.I MD. Resident in training, Urology Department,

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Section: Metabolic Diagnosismentioning

confidence: 99%

Section: Prevention and Pharmacological Treatmentmentioning

confidence: 99%

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Calcium renal lithiasis: metabolic diagnosis and medical treatment

2013

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“…9 It is well known that patients with hypercalciuria and fasting hypercalciuria have more risk of bone mineral density loss, 13 and that calcium renal stones and osteopenia/osteoporosis are two related and reciprocal diseases. 14 The role of urinary calcium in the physiology of stones is very important, due to the main metabolic risk factor found in patients with lithiasis.…”

Section: Calciuria In Postmenopausal Women With Fracturementioning

confidence: 99%

“…14 The role of urinary calcium in the physiology of stones is very important, due to the main metabolic risk factor found in patients with lithiasis. 9 The study of calciuria is recommended in women with osteoporosis and osteoporotic fracture. Other metabolic risk factors, such as oxaluria, citraturia and uricosuria, should be measured; however, their prevalence in these patients could be less important even though lithogenic risk factors occur with calciuria.…”

Section: Calciuria In Postmenopausal Women With Fracturementioning

confidence: 99%

The Importance of Urinary Calcium in Postmenopausal Women With Osteoporotic Fracture

Rull

Cano-García

Martín

et al. 2015

CUAJ

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Introduction: Calcium stones are associated with osteoporosis and manifested mainly by elevated fasting urinary calcium/creatinine ratio. The objective of this study is to demonstrate the presence of abnormal metabolism of calcium and calciuria in women with osteoporotic fracture with no previously known renal lithiasis compared to women without osteoporosis and without renal lithiasis. Methods: In total, 87 women were included in the study. They were divided into two groups: Group 1 with 55 postmenopausal women with osteoporotic fracture and without renal lithiasis; and Group 2 with 32 postmenopausal women without osteoporosis and without history of renal lithiasis. The following parameters of phospho-calcium metabolism were analyzed: calciuria 24-hour, oxaluria 24-hour, uricosuria 24-hour, and citraturia 24-hour. The presence of hypercalciuria, hyperoxaluria, hyperuricosuria, and hypocitraturia was compared between groups. Statistical significance was set at p ≤ 0.05. Results: The mean age was 70.1 ± 13.8 in Group 1 and 56.7 ± 6.4 in Group 2 (p = 0.0001). Women in Group 1 had higher levels of serum alkaline phosphatase (p < 0.05) and fasting urinary calcium/creatinine ratio (p < 0.05). The percentage of patients with hypercalciuria in Group 1 (40%) was higher compared to Group 2 (18.8%) and statistically significant (p = 0.04). There were no statistically significant differences in the percentage of hyperoxaluria, hyperuricosuria, and hypocitraturia between groups. This study has its limitations including its cross-sectional nature at a unique centre and its low number of patients. Conclusion: The determination of urinary calcium and fasting calcium/creatinine ratio in postmenopausal women with osteoporotic fracture without renal lithiasis may facilitate individualization of medical therapy and decreasing lithogenic risk.

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The value of hypercalciuria in patients with osteopenia versus osteoporosis

et al. 2016

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The aim of this study was to analyze the presence of lithogenic metabolic factors in the blood and urine of patients with osteopenia versus osteoporosis. This is a cross-sectional study including 67 patients who were divided into two groups according to the presence of either osteopenia or osteoporosis as measured by bone densitometry: group 1-40 patients with osteopenia (22 men and 18 women) and group 2-27 patients with osteoporosis (13 men and 14 women). Metabolic studies were performed on the blood and urine; statistical analysis was performed comparing means and conducting linear correlation and multivariate analyses with SPSS. Statistical significance was considered to be p ≤ 0.05. The mean age of patients in group 1 was 52.9 ± 12.8 years versus 50.3 ± 11.4 in group 2; the difference was not statistically significant. In group 2, higher levels of osteocalcin, β-crosslaps, urinary calcium, fasting urine calcium/creatinine, 24 h urine calcium/creatinine and 24 h oxaluria were observed compared to group 1. In the multivariate analysis, only the β-crosslaps and urinary calcium were independently associated with osteoporosis. It would be advisable to determine the urinary calcium levels in patients with osteoporosis since altered levels may necessitate modifying the diagnostic and therapeutic approach to osteoporosis.

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Estudio de factores físico-químicos en pacientes con litiasis renal

Cited by 10 publications

References 34 publications

Calcium renal lithiasis: metabolic diagnosis and medical treatment

Calcium renal lithiasis: metabolic diagnosis and medical treatment

The Importance of Urinary Calcium in Postmenopausal Women With Osteoporotic Fracture

The value of hypercalciuria in patients with osteopenia versus osteoporosis

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