Estudio comparativo entre formas agudas y crónicas de tuberculosis pleural

Haro, M.; Manzano, Juan Ruíz; Ribas, J.; Manterola, J. M.; Ausina, V.; Vilà, Xavier; Morera, Josep

doi:10.1016/s0300-2896(15)30624-4

Cited by 2 publications

(1 citation statement)

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“…Increased PAI-1 and decreased t-PA was associated with pleural thickness in pleural TB [17,18]. Previous study showed pleural thickness may be associated with lower glucose and higher ADA in pleural effusion [19][20][21]. Therefore, the present results regarding to higher ADA, PAI-1, TGF-β and lower glucose and t-PA associated with pleural based mass should be reasonable.…”

Section: Discussionsupporting

confidence: 55%

Contradictory Pleural based Mass Occurred in Patients with Pleural Tuberculosis during the Treatment: A Clinical Observational Study in China

Dong¹,

Zhang²,

Sun³

et al. 2021

Preprint

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Background: Recent years pleural based mass newly occurred during anti-tuberculosis (TB) treatment had been observed in patients with pleural TB. Its occurrence is contradictory and unfavorable for the outcome of patients. This study aims to explore its clinical, pathological and bacteriological characteristics.Methods: Patients newly diagnosed as pleural TB met included criterion were prospectively enrolled into the study. Patients were followed up throughout the treatment, clinical data were recorded. Percutaneous biopsy and surgical tissues from pleural based mass were pathologically and bacteriologically examined, related clinical factors were calculated by Fagan's nomogram and ROC curve. Results: A total of 122 patients with pleural TB were enrolled. 34.4% of them (42/122) were newly observed pleural based mass during the treatment, 12 cases received surgical resection at the 12±0.5 months of treatment course, under surgical observation only 58.3% of them (7 /12) were located on pleura, 41.7% (5/12) of them were located in lung parenchyma. Pathological observations showed that pleural based masses were divided into three types: granulomatous inflammation, fibrous hyperplasia and necrosis type. Mycobacterium tuberculosis PCR was positive in 57.1% of cases (24/42), any first-line anti-TB drug resistance gene mutation was positive in only 9.5% (4/42). Besides 12 cases receiving surgical operation, there were 86.7% of patients (26/30) in which pleural based mass still existed at the end of 12 months course. Young age, pleural thickness and adhesion, higher LDH, ADA, TGF-β and PAI-1, lower GLU and t-PA in pleural effusion were risk factors of occurring pleural based mass. Conclusions: Pleural based mass had been observed in about one third of patients with pleural TB, which were located in lung or pleura and divided into three pathological types. There are some clinical characteristics as its predictive risk factors.

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Section: Discussionsupporting

confidence: 55%