Estudio comparativo de melatonina contra los tratamientos inmunomoduladores (interferón beta y acetato de glatirámero) en un modelo murino de esclerosis múltiple

González, ez Juan Carlos Mayagoitia; Ramírez-Jirano, Luis Javier; Martínez, D.Z. García; Ortíz, Genaro Gabriel; Jave-Suárez, Luis F; Cortes, Carmen; Quintero, O.K. Bitzer

doi:10.1016/j.nrl.2018.01.007

Cited by 7 publications

(1 citation statement)

References 37 publications

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“…The immunomodulatory and anti-inflammatory effects of melatonin allow it to inhibit the expression and activation of NF-κB, preventing its translocation to the nucleus and its binding to DNA (Maldonado et al 2010 ; Escribano et al 2014 ), thus reducing the synthesis of inflammatory mediators and, ultimately, suppressing inflammation (Ramos González et al 2018 ; Sánchez-López et al 2018 ; Zhao et al 2019 ; Luo et al 2020 ).…”

Section: Immunomodulator and Anti-inflammatory Effect Of Melatonin In...mentioning

confidence: 99%

Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action

et al. 2022

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Background Melatonin is an indole hormone secreted primarily by the pineal gland that showing anti-oxidant, anti-inflammatory and anti-apoptotic capacity. It can play an important role in the pathophysiological mechanisms of various diseases. In this regard, different studies have shown that there is a relationship between Melatonin and Multiple Sclerosis (MS). MS is a chronic immune-mediated disease of the Central Nervous System. Aim The objective of this review was to evaluate the mechanisms of action of melatonin on oxidative stress, inflammation and intestinal dysbiosis caused by MS, as well as its interaction with different hormones and factors that can influence the pathophysiology of the disease. Results Melatonin causes a significant increase in the levels of catalase, superoxide dismutase, glutathione peroxidase, glutathione and can counteract and inhibit the effects of the NLRP3 inflammasome, which would also be beneficial during SARS-CoV-2 infection. In addition, melatonin increases antimicrobial peptides, especially Reg3β, which could be useful in controlling the microbiota. Conclusion Melatonin could exert a beneficial effect in people suffering from MS, running as a promising candidate for the treatment of this disease. However, more research in human is needed to help understand the possible interaction between melatonin and certain sex hormones, such as estrogens, to know the potential therapeutic efficacy in both men and women.

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Section: Immunomodulator and Anti-inflammatory Effect Of Melatonin In...mentioning

confidence: 99%

Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action

et al. 2022

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The role of melatonin in Multiple Sclerosis

Skarlis

Anagnostouli

2019

Neurol Sci

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The effects of melatonin supplementation on neurobehavioral outcomes and clinical severity in rodent models of multiple sclerosis; a systematic review and meta-analysis

Razmaray,

Nasiri,

Vakilipour

et al. 2024

Inflammopharmacol

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Estudio comparativo de melatonina contra los tratamientos inmunomoduladores (interferón beta y acetato de glatirámero) en un modelo murino de esclerosis múltiple

Abstract: Further studies are needed to evaluate the molecular mechanisms involved in the behaviour of MLT in EAE, and to quantify other cytokines in different biological media in order for MLT to be considered an anti-inflammatory agent capable of regulating MS.

Cited by 7 publications

References 37 publications

Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action

Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action

The role of melatonin in Multiple Sclerosis

The effects of melatonin supplementation on neurobehavioral outcomes and clinical severity in rodent models of multiple sclerosis; a systematic review and meta-analysis

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