Estudio comparativo de las series históricas de carcinoma diferenciado de tiroides en dos centros hospitalarios de tercer nivel españoles en relación a series norteamericanas

Reverter, Jordi L.; Colomé, E.; Halperín, Irene; Julián, Teresa; Díaz, Gonzalo; Mora, Mireia; Sanmartı́, Anna; Puig-Domingo, Manel

doi:10.1016/j.endonu.2010.06.004

Cited by 15 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, between 15 and 25% of cases may undergo a dedifferentiation process with loss of the ability to trap radioiodine, making this treatment ineffective, and worsening the prognosis [36], [37].…”

Section: Discussionmentioning

confidence: 99%

Benign and Malignant Nodular Thyroid Disease in Acromegaly. Is a Routine Thyroid Ultrasound Evaluation Advisable?

et al. 2014

Self Cite

View full text Add to dashboard Cite

Data on the prevalence of benign and malignant nodular thyroid disease in patients with acromegaly is a matter of debate. In the last decade an increasing incidence of thyroid cancer has been reported. The aim of this study was to evaluate the prevalence of goiter, thyroid nodules and thyroid cancer in a large series of patients with acromegaly with a cross-sectional study with a control group. Six Spanish university hospitals participated. One hundred and twenty three patients (50% men; mean age 59±13 years; disease duration 6.7±7.2 years) and 50 controls (51% males, mean age 58±15 years) were studied. All participants underwent thyroid ultrasound and fine needle aspiration. Cytological analysis was performed in suspicious nodules between 0.5 and 1.0 cm and in all nodules greater than 1.0 cm. Goiter was more frequently found in patients than in controls (24.9 vs. 8.3%, respectively; p<0.001). Nodular thyroid disease as well as nodules greater than 1 cm were also more prevalent in acromegalic patients (64.6%, vs. 28.6%, p<0.05 and 53.3 vs. 28.6%, respectively; p<0.05), and all underwent fine needle aspiration. Suspicious cytology was detected in 4 patients and in none of the controls. After thyroidectomy, papillary thyroid carcinoma was confirmed in two cases (3.3% of patients with thyroid nodules), representing 1.6% of the entire group of patients with acromegaly (2.4% including a case with previously diagnosed papillary thyroid carcinoma). These data indicated that thyroid nodular disease and cancer are increased in acromegaly, thus justifying its routine ultrasound screening.

show abstract

Section: Discussionmentioning

confidence: 99%

Benign and Malignant Nodular Thyroid Disease in Acromegaly. Is a Routine Thyroid Ultrasound Evaluation Advisable?

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…These patients have a poor prognosis, as no efficacious treatments are available at present 24,25 and thus, the search for new treatment targets, mostly for stage III and IV cases, is currently ongoing [3], [4].…”

Section: Discussionmentioning

confidence: 99%

The Truncated Isoform of Somatostatin Receptor5 (sst5TMD4) Is Associated with Poorly Differentiated Thyroid Cancer

et al. 2014

Self Cite

View full text Add to dashboard Cite

Somatostatin receptors (ssts) are expressed in thyroid cancer cells, but their biological significance is not well understood. The aim of this study was to assess ssts in well differentiated (WDTC) and poorly differentiated thyroid cancer (PDTC) by means of imaging and molecular tools and its relationship with the efficacy of somatostatin analog treatment. Thirty-nine cases of thyroid carcinoma were evaluated (20 PDTC and 19 WDTC). Depreotide scintigraphy and mRNA levels of sst-subtypes, including the truncated variant sst5TMD4, were carried out. Depreotide scans were positive in the recurrent tumor in the neck in 6 of 11 (54%) PDTC, and in those with lung metastases in 5/11 cases (45.4%); sst5TMD4 was present in 18/20 (90%) of PDTC, being the most densely expressed sst-subtype, with a 20-fold increase in relation to sst2. In WDTC, sst2 was the most represented, while sst5TMD4 was not found; sst2 was significantly increased in PDTC in comparison to WDTC. Five depreotide positive PDTC received octreotide for 3–6 months in a pilot study with no changes in the size of the lesions in 3 of them, and a significant increase in the pulmonary and cervical lesions in the other 2. All PDTC patients treated with octreotide showed high expression of sst5TMD4. ROC curve analysis demonstrated that only sst5TMD4 discriminates between PDTC and WDTC. We conclude that sst5TMD4 is overexpressed in PDTC and may be involved in the lack of response to somatostatin analogue treatment.

show abstract

“…However, this represents the largest cohort of patients with DTC reported in Spain, and the one with the longest mean follow-up time after the joint series of two hospitals reported by Reverter et al 22 Although several physicians were involved in the diagnosis and treatment of these patients during this period, the management protocol remained constant in general, and differences between the early and late years were due to improvements in diagnostic procedures, with the introduction of thyroid ultrasound examination and ultrasound-guided FNA to assess thyroid nodules.…”

Section: Discussionmentioning

confidence: 87%

Comparison of differentiated thyroid carcinoma staging systems in a Spanish population

Melero

Llanes

Sambo

et al. 2015

Endocrinología y Nutrición (English Edition)

View full text Add to dashboard Cite

Estudio comparativo de las series históricas de carcinoma diferenciado de tiroides en dos centros hospitalarios de tercer nivel españoles en relación a series norteamericanas

Cited by 15 publications

References 12 publications

Benign and Malignant Nodular Thyroid Disease in Acromegaly. Is a Routine Thyroid Ultrasound Evaluation Advisable?

Benign and Malignant Nodular Thyroid Disease in Acromegaly. Is a Routine Thyroid Ultrasound Evaluation Advisable?

The Truncated Isoform of Somatostatin Receptor5 (sst5TMD4) Is Associated with Poorly Differentiated Thyroid Cancer

Comparison of differentiated thyroid carcinoma staging systems in a Spanish population

Contact Info

Product

Resources

About