Estudio clínico y determinación de la parasitemia en un grupo de pacientes infectados por Trypanosoma cruzi de la región de Atacama, Chile

Carrasco, Mauricio; L, Winston Andrade; L, María Isabel Jercic; O, Jorge Fernández; C, Claudio Miranda; Q, Juan Rivera; González, Juan Carlos; A, Luis González; Ramı́rez, Eugenio

doi:10.4067/s0034-98872003000800007

Cited by 2 publications

(2 citation statements)

References 11 publications

(10 reference statements)

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“…None of the non-endemic studies identified an association between parasite DNA detection in peripheral blood and CCC. Six studies reported greater positive PCR ratios among patients with CCC than in patients with ICD although differences did not achieve statistical significance ( 36 , 37 , 41 , 42 , 44 , 45 ). The remaining 4 studies reported a positive PCR rate that favored patients with ICD ( 38 – 40 , 43 ).…”

Section: Resultsmentioning

confidence: 94%

“…They all were performed in endemic regions and found a greater PCR positivity between patients with CCC and ICD with OR s of 5.17 ( CI 1.06–25.36) and 3.48 ( CI 2.31–5.23). In one study, although a risk ratio (RR) of 4.45 was reported, it included both cardiac and digestive forms on the analysis, and when OR was calculated with only CCC patients, we could not achieve statistical significance ( 36 ). None of the non-endemic studies identified an association between parasite DNA detection in peripheral blood and CCC.…”

Section: Resultsmentioning

confidence: 99%

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Association Between Trypanosoma cruzi DNA in Peripheral Blood and Chronic Chagasic Cardiomyopathy: A Systematic Review

Bosch-Nicolau

Espinosa-Pereiro

Salvador

et al. 2022

Front. Cardiovasc. Med.

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Chronic chagasic cardiomyopathy (CCC) is the most important complication of patients with Chagas disease (CD). The role of persistent detection of DNA in peripheral blood and its association to CCC is unknown. We performed a systematic review up to July 2021, including studies that reported ratios of CCC and PCR positivity among non-treated adult patients. We identified 749 records and selected 12 for inclusion corresponding to 1,686 patients. Eight studies were performed in endemic countries and 4 in non-endemic countries. Only two studies showed an association between CCC and Trypanosoma cruzi parasitemia by means of PCR detection. Six studies reported greater positive PCR ratios among patients with CCC than in the patients with indeterminate chagas disease (ICD) with no statistical significance. A significant risk of bias has been detected among most of the studies. Therefore, while we performed a meta-analysis, wide inter-study heterogeneity impeded its interpretation.ConclusionsWith the available information, we could not establish a correlation between PCR-detectable parasitemia and CCC.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020216072, identifier: CRD42020216072.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Association Between Trypanosoma cruzi DNA in Peripheral Blood and Chronic Chagasic Cardiomyopathy: A Systematic Review

Bosch-Nicolau

Espinosa-Pereiro

Salvador

et al. 2022

Front. Cardiovasc. Med.

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Natural infection of Trypanosoma cruzi in a dog with heart lesions: a case report from Malinalco, State of Mexico, Mexico

Barbabosa‐Pliego¹,

Uxua²,

E³

et al. 2010

RRTM

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Background: Chagas disease is widely distributed in tropical and subtropical regions of the Americas, including more than 50% of the Mexican territory. The southern region of the State of Mexico (the Tejupilco Sanitary Jurisdiction) was recently reported as endemic; however the pathogenicity of the circulating strains has not been studied in depth. Recent studies have reported Trypanosoma cruzi seropositive dogs in the villages of Malinalco and Zumpahuacan in the central south of the State of Mexico. Dogs are epidemiologically important, because the evolution of symptoms and pathology of Chagas disease in this vertebrate mimics the human disease, and because dogs maintain the domestic cycle of parasite transmission. Objectives: To study the clinical and pathological findings of a dog showing serological evidence of T. cruzi infection. The study of the canine, identified in the Malinalco locality, is expected to contribute to the general characterization and behavior of the pathogen in the region. Methods: Clinical (electrocardiogram, echocardiogram and clinical exam), pathological (necropsy and histopathology) and serologic (indirect hemagglutination test and enzyme-linked immunoassay) analyses were conducted in a 4-year-old dog naturally infected with T. cruzi. Results: The canine was diagnosed with dilated cardiomyopathy and hepatomegaly associated with congestive cardiac insufficiency, presumably provoked by chronic myocarditis and derived from natural infection with T. cruzi. Conclusion: T. cruzi strains circulating in the village of Malinalco, State of Mexico are pathogenic for dogs, and could be affecting other domestic animals, and even infecting humans in the region.

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Estudio clínico y determinación de la parasitemia en un grupo de pacientes infectados por Trypanosoma cruzi de la región de Atacama, Chile

Abstract: Background: Trypanosoma cruzi infection is endemic in (Rev Méd Chile 2003; 131: 881-6).

Cited by 2 publications

References 11 publications

Association Between Trypanosoma cruzi DNA in Peripheral Blood and Chronic Chagasic Cardiomyopathy: A Systematic Review

Association Between Trypanosoma cruzi DNA in Peripheral Blood and Chronic Chagasic Cardiomyopathy: A Systematic Review

Natural infection of Trypanosoma cruzi in a dog with heart lesions: a case report from Malinalco, State of Mexico, Mexico

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