Estrus induction in Beagle bitches with the GnRH-agonist implant containing 4.7 mg Deslorelin

Walter, B.; Otzdorff, Christiane; Brugger, Nicolas; Braun, J.

doi:10.1016/j.theriogenology.2010.11.022

Cited by 35 publications

(75 citation statements)

References 17 publications

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“…Prolonged administration of GnRH agonists leads to desensitization of the pituitary gland and effectively inhibited the pituitarygonadal axis 2,16 . However, treatment with GnRH agonists initially induces a large increase in the concentrations of LH and FSH (flare-up effect) that is sometimes associated with estrus induction, with or without ovulation 6,12 . This agonist-induced estrus is generally regarded as an inherent disadvantage when the implant was used to postpone puberty or for suppression of estrus.…”

Section: Discussionmentioning

confidence: 99%

“…Long-acting GnRH agonists can be used for indications such as preventing puberty in both sexes; controlling of estrus cycle and treating post-spaying urinary incontinence [3][4][5][6] and controlling the risk of recurrence of mammary neoplasia, prevention of mammary tumour metastatic disease and the termination of pregnancy in bitches [7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

“…GnRH agonists have been used both in canine estrus induction and prevention 3,5,6,10 . Chronic administrations of GnRH agonists result in downregulation and desensitation of pituitary GnRH receptors and, therefore, in a complete suppression of gonadal function 5,6,11 .…”

Section: Introductionmentioning

confidence: 99%

“…Chronic administrations of GnRH agonists result in downregulation and desensitation of pituitary GnRH receptors and, therefore, in a complete suppression of gonadal function 5,6,11 . A significant advance for their clinical use was obtained by the development of slow-release agonists that can be easily administered intramuscularly or implanted subcutaneously thus delivering constant doses of GnRH for 3-12 months depending on the formulation 5,[12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

“…A sharp, initial stimulatory gonadotropin response to GnRH agonist treatment known as 'flare-up' occurs after implant insertion which results in an increased release of FSH and LH 15,16 . In dogs, estrus can be induced within 3 to 10 days after treatment 2,6,17 . Trigg et al 12 noted the same phenomenon for animals aged seven months or more.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Clinical and Endocrine Short-Term Effects of GnRH Analogue Deslorelin in Prepubertal Bitches: Does A “Flare-up” Occur?

Kaya¹,

Aslan²,

Kaya³

et al. 2013

Kafkas Univ Vet Fak Derg

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SummaryLong-acting GnRH agonists have been used both in canine estrus induction and prevention. The objective of the study was to investigate the clinical and endocrine short-term effects of a deslorelin implant (4.7 and 9.4 mg) in terms of initial "flare-up" in prepubertal bitches. Fourteen healthy, cross-breed prepubertal female dogs, aged 4 months, were used in the study. An implant containing 9.4 mg (G1, n=5) and 4.7 mg (G2, n=4) deslorelin (Suprelorin®) or a placebo (sodium chloride 0.9%, G3, n=5) was inserted subcutaneously. Estrus was monitored once daily by physical and sexual behavioral changes. Vaginal cytology, serum progesterone (P4) and estradiol 17β (E2) concentrations were monitored weekly for the first five weeks throughout the treatment. None of the bitches in the treatment (G1 and G2) and control (G3) group showed any signs of estrous throughout the study period. No local reactions were observed at the implantation site. Two bitches showed an increase in serum P4 concentrations (>1.0 ng/ml) in G1 (2/5; 40%), however, only one of these two animals (P4=6.37 ng/ml) showed an increase in serum E2 concentrations up to 37 pg/ml. No marked increase in serum P4 and E2 concentrations were observed during the first 13 weeks of treatment in G2. These data demonstrate that in prepubertal bitches, insertion of a deslorelin implant does not cause a "flare-up effect" which commonly occurs in anestrus adult bitches during the first month after implantation. However, further studies are needed to demonstrate that the "flare-up" effect of deslorelin implant in bitches especially during later prepubertal stages. Keywords: Prepubertal bitches, Suprelorin®, Flare-up effect Prepubertal Köpeklerde GnRH Analoğu Deslorelinin Kısa DönemKlinik ve Endokrinolojik Etkileri: "Flare-up" Gözlenir mi? ÖzetUzun etkili GnRH agonistleri köpeklerde hem östrusun uyarılmasında hem de baskılanmasında kullanılmaktadırlar. Bu çalışmada, pubertas öncesi dönemdeki dişi köpeklerde deslorelin implant (4.7 ve 9.4 mg) kullanımının "flare-up" dönemi olarak değerlendirilebilecek klinik ve endokrinolojik kısa dönem etkilerinin varlığı araştırılmıştır. Bu amaçla pubertas öncesi dönemde olduğu belirlenen ortalama 4 aylık yaşta on dört adet sağlıklı melez dişi kopek kullanıldı. Köpeklere deri altı yolla 9.4 mg (G1, n=5) ve 4.7 mg (G2, n=4) deslorelin (Suprelorin®) etken maddesi içeren implantlar ya da plasebo (sodyum klorür %0.9; G3; n=5) uygulandı. Östrus belirtileri günlük olarak fiziksel değişiklikler ve davranış değişiklikleri yönünden takip edildi. Ayrıca çalışma süresince vaginal sitoloji, serum progesteron (P4) ve östradiol 17β (E2) konsantrasyonları haftalık olarak izlendi. Tedavi (G1 ve G2) ve kontrol grubundaki (G3) hayvanların hiçbirinde östrus bulgusu belirlenmedi. İmplantın yerleştirildiği bölgede herhangi bir lokal yan etki gözlenmedi. Grup 1'de iki köpekte (2/5; %40) serum P4 düzeyinde bir artış gözlenirken, bu köpeklerden yalnızca birinde (P4=6,37 ng/ml) serum E2 düzeyinin 37 pg/ml'ye kadar yükseldiği belirlendi. Grup 2'de 13 haftal...

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Section: Discussionmentioning

confidence: 99%