Estrogenic Regulation of Cytoplasmic Receptor Populations in Estrogen-Responsive Tissues of the Rat

Cidlowski, John A.; Muldoon, Thomas G.

doi:10.1210/endo-95-6-1621

Cited by 110 publications

(22 citation statements)

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“…= Ovariectomy. [12] and our earlier obser vations [13]. Into this wide range fell the values of all animals irrespective of the treatments studied.…”

Section: In Vivo Experimentssupporting

confidence: 68%

Chemotherapeutic Agents and Estradiol Receptor Binding Capacity

Görlich¹,

Heise²,

Számel³

et al. 1979

Oncology

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Cytotoxic agents used for the treatment of breast cancer did not inhibit the growth of uterus following estradiol injection to ovariectomized rats. They had no effect on the estradiol binding ability and on the dissociation constant of estradiol receptor binding of rat uterus. In addition, 1,2:5,6-dianhydrogalactitol, a highly active, proximal alkylating agent, applied in vitro did not alter the relative binding ability of tamoxifen to the cytoplasmic estradiol receptor of rat uterus and human breast cancer tissue. In summary, the present experiments did not reveal any disadvantageous interaction between simultaneously administered hormonal and cytotoxic drugs.

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“…= Ovariectomy. [12] and our earlier obser vations [13]. Into this wide range fell the values of all animals irrespective of the treatments studied.…”

Section: In Vivo Experimentssupporting

confidence: 68%

Chemotherapeutic Agents and Estradiol Receptor Binding Capacity

Görlich¹,

Heise²,

Számel³

et al. 1979

Oncology

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“…However, castration of mature rats does not reduce cytoplasmic estrogenreceptors [15]. Thus, it is unlikely that the small difference in serum estro gen concentration we noted between the control and osteoporotic groups would result in the 3-fold decrease in 3H-E2 binding observed in the osteo porotic group.…”

Section: Discussionmentioning

confidence: 66%

Impaired Binding of Estradiol to Vaginal Mucosal Cells in Postmenopausal Osteoporosis

Bartizal¹,

Coulam²,

Gaffey³

et al. 1976

Gynecol Obstet Invest

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Estrogen binding to vaginal mucosa (an easily accessible estrogen-sensitive tissue) was studied in 20 osteoporotic women and in 20 normal postmenopausal women. Mean age, years since menopause, and serum levels of estrogen, luteinizing hormone, and follicle-stimulating hormone did not differ significantly between the groups. Binding of tritiated-estradiol to vaginal epithelial cells was assessed by quantitative autoradiography and corrected for nonspecific binding by pretreatment of duplicate samples with an excess of unlabeled estrogen to saturated binding sites. Results (mean ± SE) expressed as counts/cell showed that binding was significantly less (p < 0.001) in the osteoporotic women (44.1 ± 4.0) than in the normal postmenopausal women (153.3 ± 39.3). Assuming that the quantity of estrogen receptors in bone paralleled those in vaginal cells, the data suggest that a defect in specific estrogen receptors including bone may be one of the fundamental abnormalities responsible for postmenopausal osteoporosis.

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“…One could propose different explanations for this increase. It has been proposed that in some tissues estradiol induces its own receptors [25,28], though this does not seem to be the case here as estradiol levels only increased on day 15, 24 h after the increase in cytosolic receptors was determined. On the other hand, our labora tory described that anterior pituitary receptors are regu lated by the central nervous system [29].…”

Section: Discussionmentioning

confidence: 69%

Anterior Pituitary Estradiol Receptors Associated with the Reinstatement of Ovulatory Cycles after Lactation Interruption in the Rat

Lux‐Lantos

Hockl²,

Tesone³

et al. 1994

Neuroendocrinology

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The participation of adenohypophyseal estradiol receptors in the reinstatement of ovulatory cycles after lactation interruption was investigated. In rats whose pups were removed on day 13 postpartum (LRX), prolactin levels fell as from 1600 h on the same day, estradiol peaked on the morning of day 15 and gonadotropins and prolactin (PRL) surged on the afternoon of day 15. No significant changes in gonadotropins or estradiol levels were observed in rats which remained with their litters (LRP); in these rats daily afternoon surges of PRL were detected. No significant variations in anterior pituitary nuclear or cytosolic estradiol receptors were determined in LRP rats. In the nuclear fraction of LRX rats, an important increase (430.8 ± 124.9%) in receptor titers was observed on day 15. In these animals a significant increase (34.8 ± 1.3%) in cytosolic estradiol receptors was observed on day 14, followed by a fall on day 15 (–31.6 ± 6.6%) in comparison to day 13 levels. The receptor variations observed on day 15 closely resemble estrous cyclic changes determined in adult females. However, an observation which does not resemble those cycle variations is the increase in cytosolic receptors observed on day 14 in LRX rats. This increase may be the consequence of a decrease in dopamine levels induced by pup removal. To our knowledge this is the first time that the involvement of pituitary estradiol receptors in the reinstatement of ovulatory cycles after lactation interruption has been described.

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Estrogenic Regulation of Cytoplasmic Receptor Populations in Estrogen-Responsive Tissues of the Rat

Cited by 110 publications

References 0 publications

Chemotherapeutic Agents and Estradiol Receptor Binding Capacity

Chemotherapeutic Agents and Estradiol Receptor Binding Capacity

Impaired Binding of Estradiol to Vaginal Mucosal Cells in Postmenopausal Osteoporosis

Anterior Pituitary Estradiol Receptors Associated with the Reinstatement of Ovulatory Cycles after Lactation Interruption in the Rat

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