Estrogenic Flavonoids from <i>Artemisia vulgaris</i> L.

Lee, Sang-Jun; Chung, Ha-Yull; Maier, Camelia; Wood, Angela R.; Dixon, Richard A.; Mabry, Tom J.

doi:10.1021/jf9801264

Cited by 75 publications

(51 citation statements)

References 13 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The phytochemical studies on this plant species reported that it contains a number of flavonoids (e.g., apigenin, eriodictyol, kaempferol, luteolin) as the major constituents, together with monoterpenes, sesquiterpene lactones, and other compounds. [18][19][20] Flavonoids are well known antioxidants and attract a tremendous amount of interest among researchers as possible therapeutic agents for diseases mediated by free radicals. Flavonoids are also effective inhibitors of several enzymes including XO, cyclooxygenase, and lipooxigenase.…”

Section: Resultsmentioning

confidence: 99%

Xanthine Oxidase Inhibitory Activity of Vietnamese Medicinal Plants

Nguyen

Awale

Tezuka

et al. 2004

Biological & Pharmaceutical Bulletin

180

113

View full text Add to dashboard Cite

Natural products are excellent sources of lead compounds in the search for new medicaments for the treatment of diseases. The largest present underexplored source of such materials lies in tropical and subtropical regions of the world. In these areas, a long tradition of ethnobotanical medicine often exists and offers a rich and relatively untapped source for the discovery of new drugs from natural products. Vietnam, a tropical Southeast Asian country, also has a long history of traditional medicine systems. 1) However, systematic exploitation of these natural resources for their human health benefits has not been carried out to a significant degree.Gout is a common disease with a worldwide distribution. Hyperuricemia, which is associated with gout, results from the overproduction or underexcretion of uric acid and is greatly influenced by a high dietary intake of foods rich in nucleic acids, such as meats (especially organ meats), leguminous seeds, some types of seafood, and food yeasts. 2,3) During the last step of purine metabolism, xanthine oxidase (XO) catalyses the oxidation of xanthine and hypoxanthine into uric acid. 4) Uricosuric drugs which increase the urinary excretion of uric acid, or XO inhibitors which block the terminal step in uric acid biosynthesis, can lower the plasma uric acid concentration, and are generally employed for the treatment of gout.5) Allopurinol is a clinically used XO inhibitor in the treatment of gout, but this drug suffers from many side effects such as hepatitis, nephropathy, and allergic reactions.6) Thus, new alternatives with increased therapeutic activity and less side effects are desired. Moreover, superoxide anion radicals generated by XO are involved in various pathological states such as hepatitis, inflammation, ischemiareperfusion, carcinogenesis, and aging.2,7) Thus, the search for novel XO inhibitors would be beneficial not only to treat gout but also to combat various other diseases.To identify potential XO inhibitory agents from natural sources, we have tested 288 extracts prepared from 96 selected medicinal plants, which are used by the indigenous people in Vietnam for the treatment of gout or diseases associated with symptoms such as rheumatism, arthritis and inflammation. In addition, the active constituents of Chrysanthemum sinense, which showed the most potent XO inhibitory activity, have been determined. Chemicals Xanthine oxidase (EC 1.2.3.2) from bovine milk (10 units/ml) and xanthine were obtained from Sigma Chemical Co. (St. Louis, MO, U.S.A.). Allopurinol was purchased from Wako Pure Chemical Industries, Ltd. (Osaka, Japan). Other reagents were of the highest grade available. MATERIALS AND METHODS Plant MaterialsPreparation of Samples Each medicinal plant (10-213 g) was cut into small pieces and extracted successively with MeOH (200-300 ml, reflux, 2 h, ϫ3), MeOH-H 2 O (1 : 1, 200-300 ml, reflux, 2 h, ϫ2), and water (200-300 ml, reflux, 2 h). The MeOH solution was evaporated under reduced pressure to give a MeOH extract, while MeOH-H 2 O (1 : 1) and w...

show abstract

Section: Resultsmentioning

confidence: 99%

Xanthine Oxidase Inhibitory Activity of Vietnamese Medicinal Plants

Nguyen

Awale

Tezuka

et al. 2004

Biological & Pharmaceutical Bulletin

180

113

View full text Add to dashboard Cite

show abstract

“…Estrogenic flavonoids [62]. Jaceosidine, eupafolin, luteolin, quercetin, apigenine, aesculetin, esculetin-6-methylether, and scopoletin [63].…”

mentioning

confidence: 99%

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

2011

View full text Add to dashboard Cite

“…Its extracts are recommended to women for a wide variety of gynecological problems (Chevallier 1996;OnHealth.com 2000). The most common homeopathic use of A. vulgaris is for the treatment of irregular menstruation and relief of menopausal ailments (Phillips and Foy 1990;Lee et al 1998). Different parts of A. vulgaris are also used for a multitude of other medicinal purposes including as antibacterial, anti-inflammatory, antiseptic, diaphoretic, emmenagogic, or stimulatory agents (Miller 2000).…”

Section: Namementioning

confidence: 99%

The biology of Canadian weeds. 118. Artemisia vulgaris L.

Barney

DiTommaso²

2003

Can. J. Plant Sci.

View full text Add to dashboard Cite

is an introduced rhizomatous perennial found primarily along roadsides, in waste areas, and in non-containerized nursery crops in eastern regions of Canada and the United States. Artemisia vulgaris is rapidly spreading throughout the Northern Hemisphere, and is currently found in nine Canadian provinces, as well as half of the states in the United States. Historically, A. vulgaris has been used as an herbal remedy and for flavouring beer, but recently has been identified as a primary pest of nurseries and urban landscapes, largely because of its ability to propagate easily from small rhizome fragments, and because of ineffective control strategies. The recent expansion of the nursery/landscape sector has accelerated the spread of A. vulgaris into turfgrass and landscape settings throughout the Northern Hemisphere, but especially westward towards the Pacific Coast. With few effective strategies for control, this aggressive weed has rapidly colonized new areas, often forming dense monospecific stands. Not surprisingly, species diversity of native flora in these habitats has declined following A. vulgaris colonization. The mechanisms of interference (e.g., allelopathy and competition) and current strategies for the control of A. vulgaris are discussed.

show abstract

Estrogenic Flavonoids from Artemisia vulgaris L.

Cited by 75 publications

References 13 publications

Xanthine Oxidase Inhibitory Activity of Vietnamese Medicinal Plants

Xanthine Oxidase Inhibitory Activity of Vietnamese Medicinal Plants

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

The biology of Canadian weeds. 118. Artemisia vulgaris L.

Contact Info

Product

Resources

About