Estrogenic constituents of the heartwood of Dalbergia parviflora

Umehara, Kaoru; Nemoto, Kiyomitsu; Kimijima, Kyoko; Matsushita, Ayako; Terada, Eri; Monthakantirat, Orawan; De-Eknamkul, Wanchai; Miyase, Toshio; Warashina, Tsutomu; Degawa, Masakuni; Noguchi, Hiroshi

doi:10.1016/j.phytochem.2007.07.011

Cited by 38 publications

(45 citation statements)

References 20 publications

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“…The complete absence of DPPH scavenging activity found for genistein (3) is similar to the results reported previously [22][23][24], suggesting that the R4′-OH of Ring B is not important for radical scavenging activity with this assay method. parviflora were isolated and identified as described previously [8,9].…”

Section: Sar Of D Parviflora Isoflavonoids Based On Dpph Radical Scamentioning

confidence: 99%

“…However, we recently found that the heartwood of Dalbergia parviflora is a rich source of isoflavonoids. Up to 30 isoflavonoids with a potent range of estrogenic-like activities have been isolated from this Thai folk medicine [8,9]. The plant has been used as a blood tonic and for the normalisation of menstrual cycles.…”

Section: Introductionmentioning

confidence: 99%

“…The plant has been used as a blood tonic and for the normalisation of menstrual cycles. Interestingly, the isolated isoflavonoids appear to have diversified structures that belong to the well-known subgroups of isoflavones, isoflavanones, and isoflavans [8,9]. Therefore, the objective of this study was to investigate the in vitro antioxidant activities of the library set of isoflavonoids isolated from D. parviflora.…”

Section: Introductionmentioning

confidence: 99%

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Structure and Antioxidant Activity Relationships of Isoflavonoids from Dalbergia parviflora

et al. 2014

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Abstract:The antioxidant activities of 24 isoflavonoids that were previously isolated as pure compounds from Dalbergia parviflora were evaluated using three different in vitro antioxidant-based assay systems: xanthine/xanthine oxidase (X/XO), ORAC, and DPPH. The isolates consisted of three subgroups, namely isoflavones, isoflavanones, and isoflavans, each of which appeared to have diversified substituents, and were thus ideal for the study of their structure-activity relationships (SARs). The SAR analysis was performed using the results obtained from both the inter-subgroup isoflavonoids with the same substitution pattern and the intra-subgroup compounds with different substitution patterns. The inter-subgroup comparison showed that the isoflavones exhibited the highest antioxidant activities based on all three assays. The intra-subgroup analysis showed that the additional presence of an OH group in Ring B at either R3′ or R5′ from the basic common structure of the R7-OH of Ring A and the R4′-OH (or -OMe) of Ring B greatly increased the antioxidant activities of all of the isoflavonoid subgroups and that other positions of OH and OMe substitutions exerted different effects on the activities depending on the subgroup and assay type. Therefore, based on the structural diversity of the isoflavonoids

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Section: Sar Of D Parviflora Isoflavonoids Based On Dpph Radical Scamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Structure and Antioxidant Activity Relationships of Isoflavonoids from Dalbergia parviflora

et al. 2014

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“…ER ␣ and ER ␤ show 58% sequence identity in their ligand-binding domains and approximately 96% similarity in the DNA-binding domains [7]. Both ERs bind [22][23][24]. In racemic mixtures, the preferred stereoisomers displaying the highest binding affinity towards the ER␣ and ER ␤ receptors are indicated.…”

Section: Introductionmentioning

confidence: 99%

“…Very recently, we reported the isolation and structural elucidation of estrogen-like compounds from two Thai medicinal plants, namely Dalbergia parviflora R. (Leguminosae) [22,23] and Belamcanda chinensis L. (Iridaceae) [24]. These two plant species were chosen based on their traditional uses related to their estrogenic activities: the former as a blood tonic to normalize menstruation and the latter for the regulation of menstrual disorders.…”

Section: Introductionmentioning

confidence: 99%