Estrogenic activities of Ginkgo biloba extracts

Oh, Seungmin; Chung, Kyu-Hyuck

doi:10.1016/j.lfs.2003.06.045

Cited by 81 publications

(63 citation statements)

References 24 publications

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“…Further studies on isolated flavonoids showed they could also activate ERE transcription in the presence of ER, but kaempferol and isorhamnetin activated ER␤ more potently than ER␣. Selective activation of the ER␤ subtype inhibits breast cells proliferation, thus ER␤-selective ligands are more preferred to treat osteoporosis to reduce estrogen-induced side effects (Oh and Chung, 2004;Cvoro et al, 2007). Although TSZ has been found to have estrogenic activity (Umehara et al, 2004), its effect on differential activation of ER subtypes has not been examined yet.…”

Section: Discussionmentioning

confidence: 99%

Antiosteoporotic compounds from seeds of Cuscuta chinensis

Yang

Chen

Wang

et al. 2011

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Antiosteoporotic compounds from seeds of Cuscuta chinensis

Yang

Chen

Wang

et al. 2011

Journal of Ethnopharmacology

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“…Additionally, Ginkgo biloba extracts were shown to induce proliferation of MCF-7 cells that is ER-dependent as the response could be blocked with an ER antagonist (65,66). The Ginkgo biloba extracts could, however, not induce cell proliferation of MDA-MB-231 cells (65). On the other hand, methanol extracts from M. philipinensis have previously been shown to antagonize MCF-7 cell proliferation induced by E 2 (71).…”

Section: Figurementioning

confidence: 99%

Evaluation of the Phytoestrogenic Activity of Cyclopia genistoides (Honeybush) Methanol Extracts and Relevant Polyphenols

Verhoog

Joubert

Louw

2007

J. Agric. Food Chem.

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Unfermented C. genistoides methanol extracts of different harvestings and selected polyphenols were evaluated for phytoestrogenic activity by comparing binding to both ER subtypes, transactivation of an ERE-containing promoter reporter, proliferation of MCF-7-BUS and MDA-MB-231 breast cancer cells, and binding to SHBG. The extracts from one harvesting of C. genistoides (P104) bound to both ER subtypes. All extracts transactivated ERE-containing promoter reporters via ER but not via ERR. All extracts, except P122, caused proliferation of the estrogen-sensitive MCF-7-BUS cells. Proliferation of MCF-7-BUS cells was ER-dependent as ICI 182,780 reversed proliferation. Physiologically more relevant, extracts antagonized E 2 -induced MCF-7-BUS cell proliferation. Furthermore, all extracts, except P122, induced proliferation of the estrogen-insensitive MDA-MB-231 cells, suggesting that the extracts are able to induce ER-dependent and ER-independent cell proliferation. Binding to SHBG by extracts was also demonstrated. These results clearly show that C. genistoides methanol extracts display phytoestrogenic activity and act predominantly via ER . HPLC and LC-MS analysis, however, suggests that the observed phytoestrogenic activity cannot be ascribed to polyphenols known to be present in other Cyclopia species.

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“…Os efeitos observados com o tratamento com EGb podem ser devidos a múltiplas atividades no tecido ósseo, causadas por seu efeito estrogênico (Oh & Chung, 2004), que inibe a reabsorção e promove a osteogênese (Turner et. al., 1994).…”

Section: Resultsunclassified

“…O extrato padrão (EGb 761) de Ginkgo biloba possui 24% de fitoestrógenos em sua composição, sendo os principais o kaempferol, quercetina e ishorhamnetina (Oh & Chung, 2004). Destes componentes a quercetina e o kaempferol foram efetivos em inibir in vitro a atividade de reabsorção dos osteoclastos (Wattel et al, 2003).…”

Section: Introductionunclassified

Efeito do extrato de Ginkgo biloba L., Ginkgoaceae, na osteoporose induzida em ratas Wistar

Lucinda¹,

Vieira²,

Salvador³

et al. 2010

Rev. bras. farmacogn.

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RESUMO:Este trabalho investigou os efeitos do tratamento por vinte dias com extrato de Ginkgo biloba (EGb) na osteoporose induzida por glicocorticóides. Foram utilizadas 36 ratas divididas em seis grupos (n=6): Controle, osteoporose, controle positivo, EGb1 (14 mg EGb/mg/kg/dia), EGb2 (28 mg EGb/kg/dia) e EGb3 (56 mg EGb/kg/dia). Os tratamentos foram realizados por vinte dias, após a indução da osteoporose. Após a eutanásia foram removidos o fêmur e a mandíbula de todos os animais. A mandíbula esquerda foi radiografada digitalmente para avaliação da cortical e do suporte ósseo periodontal (SOP). A análise histomorfométrica foi realizada no fêmur e mandíbula direitos. O grupo controle foi comparado ao grupo osteoporose (Teste t de Student) e os demais grupos foram submetidos a ANOVA, seguido do teste post-hoc de Dunnett. Houve redução significava do SOP mesial, percentual ósseo alveolar (POA) mandibular, percentual ósseo trabecular (POT) do fêmur no grupo osteoporose. Houve aumento do SOP mesial no grupo controle positivo, EGb2 e EGb3. O POA da mandíbula e o POT do fêmur aumentaram nos grupos EGb2 e EGb3. O EGb nas doses de 28 mg/kg e 56 mg/kg recuperou de forma significativa o SOP mesial, o POA da mandíbula e o POT do fêmur. Unitermos:Ginkgo biloba, osteoporose, radiografia, histomorfometria, alendronato de sódio, ratos.ABSTRACT: "Effect of the aqueous extract of Ginkgo biloba L., Ginkgoaceae, in induced osteoporosis in Wistar rats." The objective of this study was to investigate the effect of a 20 day treatment with extract of Ginkgo biloba (EGb) in glucocorticoid-induced-osteoporosis. 36 rats were divided into six groups (n=6): control, osteoporosis, positive control, EGb1 (14 mg EGb/kg/day), EGb2 (28 mg EGb/kg/day) and EGb3 (56 mg EGb/kg/day). Treatments were conducted for twenty days, after osteoporosis was induced. Following euthanasia the femur and mandible of all animals were removed. The left mandible was radiographed to evaluate the cortical and the periodontal bone support (PBS). The histomorphometric analysis was performed on the right mandible and the right femur. The control group was compared with the osteoporosis group (Student's t-test). The other groups were analyzed through ANOVA test followed by Dunnett post-hoc test. There was a significantly reduction in the mesial PBS, in the percentage of the alveolar bone (PAB) of the mandible and percentage of the trabecular bone (PTB) of the femur in the osteoporosis group. There was an increase in the mesial PBS in the positive control group, EGb2 and EGb3. The PAB of the mandible and the PTB of the femur increased in the EGb2 and EGb3 groups. The EGb in the 28 mg/kg and 56 mg/kg doses were effective to increase the mesial PBS, the PAB of the mandible and the PTB of the femur.Keywords: Ginkgo biloba, osteoporosis, radiography, histomorphometric, sodium alendronate, rats. INTRODUÇÃOA osteoporose é caracterizada por uma redução na quantidade de tecido ósseo por unidade de volume (Hallworth, 1998) e por uma deteriorização da microarquitetura deste tecido...

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Estrogenic activities of Ginkgo biloba extracts

Cited by 81 publications

References 24 publications

Antiosteoporotic compounds from seeds of Cuscuta chinensis

Antiosteoporotic compounds from seeds of Cuscuta chinensis

Evaluation of the Phytoestrogenic Activity of Cyclopia genistoides (Honeybush) Methanol Extracts and Relevant Polyphenols

Efeito do extrato de Ginkgo biloba L., Ginkgoaceae, na osteoporose induzida em ratas Wistar

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