Estrogen treatment reduced oxalate transporting activity and enhanced migration through the involvement of SLC26A6 in lung cancer cells

Lee, Dong‐Un; Lee, Peter Chang-Whan; Hong, Jeong Hee; Shin, Dong Min

doi:10.1016/j.tiv.2022.105373

Cited by 8 publications

(12 citation statements)

References 57 publications

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“…One member of this family, SLC26A6, is of particular interest because it has some non-canonical properties. For example, it was recently shown that SLC26A6 acts as an oncogene in hepatocellular carcinoma [ 77 ] and lung cancer [ 78 ]. The role of SLC26A6 in HNSCC is completely unexplored.…”

Section: Discussionmentioning

confidence: 99%

Gene-Expression Patterns of Tumor and Peritumor Tissues of Smoking and Non-Smoking HPV-Negative Patients with Head and Neck Squamous Cell Carcinoma

Soboleva,

Arutyunyan,

Jumaniyazova

et al. 2024

Biomedicines

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We studied the gene-expression patterns in specimens of tumor and peritumor tissue biopsies of 26 patients with head and neck carcinomas depending on smoking status. Histological and immunohistochemical examinations verified that all tumors belonged to the “classical” subgroup of head and neck carcinomas, and the HPV-negative tumor status was confirmed. The expression of 28 tumor-associated genes determined by RT-PCR was independent of patients’ sex or age, TNM status, degree of differentiation, or tissue localization. Moreover, in peritumor tissue, none of the 28 genes were differentially expressed between the groups of smoking and nonsmoking patients. During oncotransformation in both studied groups, there were similar processes typical for HNSCC progression: the expression levels of paired keratins 4 and 13 were reduced, while the expression levels of keratin 17 and CD44 were significantly increased. However, further investigation revealed some distinctive features: the expression of the genes EGFR and TP63 increased significantly only in the nonsmoking group, and the expression of IL6, CDKN2A, EGF, and PITX1 genes changed only in the smoking group. In addition, correlation analysis identified several clusters within which genes displayed correlations in their expression levels. The largest group included 10 genes: TIMP1, TIMP2, WEE1, YAP, HIF1A, PI3KCA, UTP14A, APIP, PTEN, and SLC26A6. The genetic signatures associated with smoking habits that we have found may serve as a prerequisite for the development of diagnostic panels/tests predicting responses to different therapeutic strategies for HNSCC.

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Section: Discussionmentioning

confidence: 99%

Gene-Expression Patterns of Tumor and Peritumor Tissues of Smoking and Non-Smoking HPV-Negative Patients with Head and Neck Squamous Cell Carcinoma

Soboleva,

Arutyunyan,

Jumaniyazova

et al. 2024

Biomedicines

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“…The DGKH gene has been identified previously as differentially expressed in sarcoidosis [66] ; however, it has not been found in association with severe COVID-19. SLC26A6 is translated into a protein that regulates the concentrations of multiple anions in the cell [67] , [68] , and may be affected during oxidative stress [69] . Although it has been identified as a cancer biomarker [70] , it has not been reported previously as being associated with SARS-CoV-2 infection.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomics secondary analysis of severe human infection with SARS-CoV-2 identifies gene expression changes and predicts three transcriptional biomarkers in leukocytes

Clancy

Hoffmann

Pickett

2023

Computational and Structural Biotechnology Journal

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“…Felix Knauf et al ( 108 ) found that the expression of SLC26A6 decreased in the duodenum of CFTR gene-deficient mice, intestinal oxalate secretion decreased significantly, and the deficient mice exhibited hyperoxalemia and hyperoxaluria. Estradiol can up-regulate CFTR on the surface of intestinal mucosal cells to increase the expression of SLC26A6 and regulate oxalate transport ( 109 , 110 ). Therefore, CFTR may be an upstream protein of SLC26A6.…”

Section: Slc26a6-mediated Regulation Of Oxalate Transportmentioning

confidence: 99%

Oxalate as a potent promoter of kidney stone formation

et al. 2023

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Kidney stones are among the most prevalent urological diseases, with a high incidence and recurrence rate. Treating kidney stones has been greatly improved by the development of various minimally invasive techniques. Currently, stone treatment is relatively mature. However, most current treatment methods are limited to stones and cannot effectively reduce their incidence and recurrence. Therefore, preventing disease occurrence, development, and recurrence after treatment, has become an urgent issue. The etiology and pathogenesis of stone formation are key factors in resolving this issue. More than 80% of kidney stones are calcium oxalate stones. Several studies have studied the formation mechanism of stones from the metabolism of urinary calcium, but there are few studies on oxalate, which plays an equally important role in stone formation. Oxalate and calcium play equally important roles in calcium oxalate stones, whereas the metabolism and excretion disorders of oxalate play a crucial role in their occurrence. Therefore, starting from the relationship between renal calculi and oxalate metabolism, this work reviews the occurrence of renal calculi, oxalate absorption, metabolism, and excretion mechanisms, focusing on the key role of SLC26A6 in oxalate excretion and the regulatory mechanism of SLC26A6 in oxalate transport. This review provides some new clues for the mechanism of kidney stones from the perspective of oxalate to improve the understanding of the role of oxalate in the formation of kidney stones and to provide suggestions for reducing the incidence and recurrence rate of kidney stones.

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Estrogen treatment reduced oxalate transporting activity and enhanced migration through the involvement of SLC26A6 in lung cancer cells

Cited by 8 publications

References 57 publications

Gene-Expression Patterns of Tumor and Peritumor Tissues of Smoking and Non-Smoking HPV-Negative Patients with Head and Neck Squamous Cell Carcinoma

Gene-Expression Patterns of Tumor and Peritumor Tissues of Smoking and Non-Smoking HPV-Negative Patients with Head and Neck Squamous Cell Carcinoma

Transcriptomics secondary analysis of severe human infection with SARS-CoV-2 identifies gene expression changes and predicts three transcriptional biomarkers in leukocytes

Oxalate as a potent promoter of kidney stone formation

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