Estrogen suppresses heptatic IκB expression during short-term alcohol exposure

Lee, Eric G.; Mickle-Kawar, Bethany M.; Reinke, Lester A.; Gallucci, Randle M.

doi:10.1007/s00011-012-0497-8

Cited by 10 publications

(8 citation statements)

References 58 publications

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“…There are some interesting findings on sex differences of NFkB activity, with most focusing on hepatic activity. In one study, ovariectomized female rats receiving constant estrogen administration had decreased hepatic IKB mRNA expression and increased NFkB activity following alcohol consumption compared with controls and rats receiving testosterone (Lee et al, 2012). In another study, chronic ethanol administration was found to increase hepatic levels of NFkB in female rats to a greater extent than males, a finding that may explain why alcohol-induced liver injuries are more prevalent in the females (Kono et al, 2000).…”

Section: Nfkb and Inflammation In Alcohol Abusementioning

confidence: 99%

The Role of NFkB in Drug Addiction: Beyond Inflammation

Nennig

Schank

2017

Alcohol and Alcoholism

169

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Section: Nfkb and Inflammation In Alcohol Abusementioning

confidence: 99%

The Role of NFkB in Drug Addiction: Beyond Inflammation

Nennig

Schank

2017

Alcohol and Alcoholism

169

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“…Grossman's research firstly showed the low testosterone levels were associated with poor prognosis in chronic liver diseases in 2012 ( 10 ) and 2016 ( 9 ) and Klair revealed that estrogen deficiency could increase fibrosis risk among postmenopausal women with NAFLD in 2016 ( 30 ). As for the underlying mechanism, Lee et al and Kim et al clarified that estrogen and estrogen-related receptor γ(ERRγ) affected the progression of ALD respectively via hepatic IκB ( 31 ) and CB1R-CYP2E1-mediated oxidative stress ( 15 ). Li et al proved that Foxa1/a2 played essential roles in sexual dimorphism of HCC in 2012 ( 32 ) and Zhang et al suggested that overexpression of nuclear androgen receptor driven by PI3K-AKT- mTOR pathway was associated with progression and prognosis of HCC in 2018 ( 33 ).…”

Section: Discussionmentioning

confidence: 99%

Testosterone and Estradiol as Novel Prognostic Indicators for HBV-Related Acute-on-Chronic Liver Failure

Sun

Tan

et al. 2021

Front. Med.

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Background: HBV-related acute-on-chronic liver failure (HBV-ACLF) has a high short-term mortality and urgently needs an early warning system with simplicity and high accuracy. Previous studies show that sex hormones play potential roles in the progression of HBV-related liver diseases.Aims: To explore the effect of testosterone and estradiol on the occurrence and prognosis of HBV-ACLF.Methods: A prospective cohort of 300 chronic hepatitis B (CHB) patients was enrolled among which 108 were diagnosed with HBV-ACLF at admission and 20 developed to HBV-ACLF during hospitalization. We compared the level of serum testosterone and estradiol of patients with varied ACLF background, disease severity and cirrhosis conditions and analyzed the predictive ability of short-term prognosis. A novel prognostic model involving testosterone was developed and further validated in the HBV-ACLF group.Results: The baseline estradiol level of HBV-ACLF group was significantly higher while testosterone was lower than that of non-ACLF group. The estradiol level increased while the testosterone level decreased as the number of organ failures increased. Testosterone had high accuracy in predicting the short-term mortality in HBV-ACLF (AUROC = 0.726) and estradiol did better in predicting the occurrence of ACLF during hospitalization (AUROC = 0.695). The novel prognostic model involving testosterone (TATIM model) was proved to have considerable prediction efficiency in HBV-ACLF cohort with or without cirrhosis.Conclusion: Testosterone could be utilized as short-term prognostic indicator for HBV-related ACLF and estradiol can help to predict its occurrence. TATIM model is a novel prognostic model for HBV-related ACLF with simplicity and good performance irrespectively of liver cirrhosis.Clinical Trial Registration Number: This study was based on a sub-cohort from the prospective multicenter cohort (NCT02457637).

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“…Alternatively, a previous study performed using MCF-7 cells suggested that this increase was related to the increase of p105 protein level ( 57 ) . On the other hand, another research group showed that estrogen treatment decreased liver IkB mRNA and protein expression and also increased ethanol-induced liver NF-kB levels and TNF-α expression ( 58 ) . These disparate findings are likely to be related to the cell-specific effects of estrogen and merit further analysis.…”

Section: Discussionmentioning

confidence: 99%