Estrogen-responsive genes for environmental studies

Kiyama, Ryoiti; Zhu, Yun; Kawaguchi, Keiko; Iitake, Nobuko; Wada‐Kiyama, Yuko; Dong, Shuang

doi:10.1016/j.eti.2014.09.001

Cited by 11 publications

(13 citation statements)

References 226 publications

(189 reference statements)

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“…We also examined the gene expression profiles using six functionally designated sets of genes (representing enzymes, signaling, proliferation, transcription, transport and others) ( S1 Fig ). The genes used were grouped according to their functions designated in the Entrez Gene database (see Kiyama and Zhu, 2014 [ 11 ]; Kiyama et al, 2014 [ 22 ]) and used for profiling. While most categories showed relatively high levels of correlation ( R -values: greater than 0.8), the genes related to transcription showed less ( R -values: 0.4 to 0.6).…”

Section: Resultsmentioning

confidence: 99%

Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors

2017

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Mammalian lignans or enterolignans are metabolites of plant lignans, an important category of phytochemicals. Although they are known to be associated with estrogenic activity, cell signaling pathways leading to specific cell functions, and especially the differences among lignans, have not been explored. We examined the estrogenic activity of enterolignans and their precursor plant lignans and cell signaling pathways for some cell functions, cell cycle and chemokine secretion. We used DNA microarray-based gene expression profiling in human breast cancer MCF-7 cells to examine the similarities, as well as the differences, among enterolignans, enterolactone and enterodiol, and their precursors, matairesinol, pinoresinol and sesamin. The profiles showed moderate to high levels of correlation (R values: 0.44 to 0.81) with that of estrogen (17β-estradiol or E2). Significant correlations were observed among lignans (R values: 0.77 to 0.97), and the correlations were higher for cell functions related to enzymes, signaling, proliferation and transport. All the enterolignans/precursors examined showed activation of the Erk1/2 and PI3K/Akt pathways, indicating the involvement of rapid signaling through the non-genomic estrogen signaling pathway. However, when their effects on specific cell functions, cell cycle progression and chemokine (MCP-1) secretion were examined, positive effects were observed only for enterolactone, suggesting that signals are given in certain directions at a position closer to cell functions. We hypothesized that, while estrogen signaling is initiated by the enterolignans/precursors examined, their signals are differentially and directionally modulated later in the pathways, resulting in the differences at the cell function level.

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Section: Resultsmentioning

confidence: 99%

Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors

2017

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“…Estrogen can exert these effects by a receptor-mediated mechanism -through estrogen receptor alpha [ERα], estrogen receptor beta [ERβ], and through GPR30. Once stimulated, these receptors will work through intracellular mechanisms leading to nongenomic and genomic responses, and with improving technology, we know that estrogen can regulate hundreds of genes -with the majority (~70%) being downregulated [97,98]. Since complete pathways have not been elucidated for each of the main classes of exogenous estrogenic compound, it is not known or it is unclear whether there are additive, synergistic, or potentiating effects of these compounds when humans are coexposed.…”

Section: Combination Of Metalloestrogens and Pesticidesmentioning

confidence: 99%

“…For an excellent review of GEI and the mechanism(s) by which GEI can lead to cancer formation, refer to Tabrez et al [11]. Kiyama et al [98] reported a comprehensive listing of various genes which are regulated by estrogen and reviewed their activity. They focused on the classical "endocrine disruptors, " by focusing on their cell signaling.…”

Section: Combination Of Metalloestrogens and Pesticidesmentioning

confidence: 99%

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Environmental Pesticides and Heavy Metals — Role in Breast Cancer

Wallace¹

2015

Toxicity and Hazard of Agrochemicals

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The intent of this chapter is to provide an overview to the current thoughts and ideals regarding the involvement of pesticides and heavy metals in the progress of breast cancer. The history of pesticides encompasses a few millennia, but our understanding of the pesticide action and the health consequences has only begun to develop in the last -years. Interestingly, many of these pesticides have estrogen-like activity and may be involved in the development of breast cancer. " new category of estrogen-like compounds has been identified and studied in the last years, the metalloestrogens . Heavy metals, such as cadmium, which have estrogen like activity will be discussed. Finally, we will attempt to pull together the actions of pesticides and metalloestrogens as a possible synergistic mechanism by which these toxins may work to promote breast cancer development.

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“…Compounds in the “non-chemically” similar class include food additives, pesticides, plasticizers, and environmental pollutants, including some heavy metals [ 16 ]. When examining multiple signaling pathways associated with estrogen signaling, there is a significant level of complexity that involves the interrelationship between many genes [ 16 , 17 ]. Changing the chemical structure or composition of metal-containing particles (valence state, organic or inorganic form, etc. )…”

Section: Introductionmentioning

confidence: 99%

Nanotoxicology and Metalloestrogens: Possible Involvement in Breast Cancer

Wallace

2015

Toxics

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As the use of nanotechnology has expanded, an increased number of metallic oxides have been manufactured, yet toxicology testing has lagged significantly. Metals used in nano-products include titanium, silicon, aluminum, silver, zinc, cadmium, cobalt, antimony, gold, etc. Even the noble metals, platinum and cerium, have been used as a treatment for cancer, but the toxicity of these metals is still unknown. Significant advances have been made in our understanding and treatment of breast cancer, yet millions of women will experience invasive breast cancer in their lifetime. The pathogenesis of breast cancer can involve multiple factors; (1) genetic; (2) environmental; and (3) lifestyle-related factors. This review focuses on exposure to highly toxic metals, (“metalloestrogens” or “endocrine disruptors”) that are used as the metallic foundation for nanoparticle production and are found in a variety of consumer products such as cosmetics, household items, and processed foods, etc. The linkage between well-understood metalloestrogens such as cadmium, the use of these metals in the production of nanoparticles, and the relationship between their potential estrogenic effects and the development of breast cancer will be explored. This will underscore the need for additional testing of materials used in nano-products. Clearly, a significant amount of work needs to be done to further our understanding of these metals and their potential role in the pathogenesis of breast cancer.

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Estrogen-responsive genes for environmental studies

Cited by 11 publications

References 226 publications

Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors

Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors

Environmental Pesticides and Heavy Metals — Role in Breast Cancer

Nanotoxicology and Metalloestrogens: Possible Involvement in Breast Cancer

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